How Far Is Too Far? The Ethics of Mini Brain Research
December 11, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Tagamed HB
(United States) [Available]Synonyms :
cimetidine
Class :
Drugs for peptic ulcer & H2 receptor blockers
Dosage Forms & Strengths
Solution, Oral (Hydrochloride):
400 mg/6.67ml
300 mg/5ml
Tablet, Oral:
200mg
Ti300mg
400mg
800mg
400
mg
Orally
4 times a day
for 12 weeks
or
800 mg orally twice a day for 12 weeks
200
mg
Orally
3 times a day
or
300 to 400 mg orally twice a day
Dosage Forms & Strengths
Solution, Oral (Hydrochloride):
400 mg/6.67ml
300 mg/5ml
Tablet, Oral:
200mg
300mg
400mg
800mg
Children 5 to 16 years:
20 - 40
mg/kg
Orally
daily in 3 to 4 divided doses for 4 to 8 weeks
(Do not exceed 300mg/dose)
Maintenance dose: 5 to 6 mg/kg orally once a day at bedtime
Children and adolescents:
30 - 40
mg/kg
Orally
daily in 4 divided doses
Gastric ulcer:
Children and adolescents >16 years: 800 mg orally at bedtime for up to 8 weeks
Sour stomach/Heartburn:
200 g orally daily up to 30 minutes prior to eating foods causing heartburn.
cimetidine: they may enhance the serum concentration of CYP2D6 Inhibitors
cimetidine: they may enhance the serum concentration of CYP2D6 Inhibitors
cimetidine: they may enhance the serum concentration of CYP2D6 Inhibitors
cimetidine: they may enhance the serum concentration of CYP2D6 Inhibitors
cimetidine: they may enhance the serum concentration of CYP2D6 Inhibitors
may decrease the serum concentration
may decrease the serum concentration and decrease in the efficacy
may diminish the serum concentration
may enhance the serum concentration of metformin
It may enhance the effect when combined with sufentanil by diminishing metabolism
cimetidine: they may enhance the serum concentration of amiodarone
when both drugs are combined, there may be an increased level or effect of romidepsin by affecting hepatic or intestinal enzyme cyp3a4 metabolism
it increases the effect of diphenoxylate by decreasing the metabolism
relugolix/estradiol/norethindrone
it enhances by affecting the hepatic enzyme CYP3A4 metabolism
may have an increased risk of rhabdomyolysis & myoglobinuria when combined with cimetidine
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of active metabolites of roflumilast in the serum
l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
may decrease the serum concentration of multivitamins
may decrease the serum concentration of minerals
may decrease the serum concentration of minerals
may decrease the serum concentration of minerals
may decrease the serum concentration of minerals
may decrease the serum concentration of minerals
may decrease the serum concentration of minerals
it increases the concentration of alfentanil in the serum
may enhance the serum concentration when combined with calcium channel blockers
may enhance the serum concentration when combined with calcium channel blockers
may enhance the serum concentration when combined with calcium channel blockers
may enhance the serum concentration when combined with calcium channel blockers
may enhance the serum concentration when combined with calcium channel blockers
may enhance the serum concentration when combined with lidocaine
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
cimetidine can impact the hepatic/intestinal enzyme CYP3A4 metabolism, leading to an elevation in the level or potency of intranasal midazolam
it may diminish the metabolism when combined with azelastine
It may enhance the effect when combined with tafamidis meglumine
cimetidine has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When alprazolam and cimetidine is used together, this leads to reduction in the alprazolam’s metabolism
When dexrabeprazole and cimetidine is used together, this leads to reduction in the dexrabeprazole’s metabolism
When encainide is used together with cimetidine, this leads to a reduction in the encainide’s metabolism
cimetidine: they may increase the hypotensive effect of blood viscosity reducing agents
cimetidine: they may increase the hypotensive effect of blood viscosity reducing agents
When cimetidine is used together with ouabain, this leads to reduction in cimetidine excretion
cimetidine: they may decrease the therapeutic effect of antipsychotics
cimetidine: they may decrease the therapeutic effect of antipsychotics
cimetidine: they may decrease the therapeutic effect of antipsychotics
cimetidine: they may decrease the therapeutic effect of antipsychotics
cimetidine: they may decrease the therapeutic effect of antipsychotics
cimetidine: they may diminish the serum concentration of CYP3A4 Inducers
cimetidine: they may diminish the serum concentration of CYP3A4 Inducers
cimetidine: they may diminish the serum concentration of CYP3A4 Inducers
cimetidine: they may diminish the serum concentration of CYP3A4 Inducers
cimetidine: they may diminish the serum concentration of CYP3A4 Inducers
serum levels of pramipexole are increased with cimetidine
cimetidine: it may enhance the serum concentration of lidocaine
cimetidine : it may increase the toxic effect of Methemoglobinemia Associated Agents
cimetidine : it may increase the toxic effect of Methemoglobinemia Associated Agents
cimetidine : it may increase the toxic effect of Methemoglobinemia Associated Agents
cimetidine : it may increase the toxic effect of Methemoglobinemia Associated Agents
cimetidine : it may increase the toxic effect of Methemoglobinemia Associated Agents
cimetidine leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
dried ferrous sulfate / sodium ascorbate
might reduce gastrointestinal absorption
When bacampicillin is combined with cimetidine, bacampicillin absorption and blood levels decrease by stomach acid reduction.
may reduce the therapeutic effects of cimetidine
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be a decrease in levels of serum concentration and absorption of erlotinib
increases serum level of cabazitaxel by affecting the enzyme CYP3A4
cimetidine may enhance the level and effect of docetaxel by affecting CYP3A4
when both drugs are combined, there may be an increased risk of adverse effects
cimetidine may enhance the level and effect of erdafitinib by affecting CYP3A4
may enhance the plasma concentration of fluorouracil-derived products
it increases the effect or level of palbociclib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it enhances by affecting the hepatic enzyme CYP2D6 metabolism
may enhance the serum concentration
the efficacy of benzylpenicillolyl polylysine as a diagnostic agent may be decreased with cimetidine
dried ferrous sulfate/folic acid
might reduce gastrointestinal absorption
may have a decrease in excretion when combined with cimetidin
When cimetidine is used together with oliceridine, this leads to enhanced concentration serum of oliceridine
cimetidine might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
When cimetidine is aided by hesperetin, it reduces hesperetin’s metabolism
it increases the concentration of metformin in the serum
it increases the effect of sulfamethoxazole by altering hepatic CYP2C9/10 enzyme metabolism
by altering the gastrointestinal absorption, the concentration of cyanocobalamin may be reduced with cimetidine
Actions and Spectrum:
Actions:
Cimetidine works by lowering the stomach’s acid levels. It treats problems with the stomach and intestines. It helps with acid reflux, also called GERD. Acid reflux causes throat pain and a burning feeling. Cimetidine prevents and treats ulcers in the digestive system. It stops too much stomach acid. This helps with GERD symptoms and heals ulcers in the stomach and intestines.
Spectrum:
Cimetidine aids with stomach troubles. This medicine helps with peptic ulcers, heartburn, and a few skin issues. These include light sensitiveness, skin irritation, hives, and also warts. It works by blocking certain receptors. Cimetidine opposes a type of receptor called H2. So this drug is an H2 receptor antagonist.
CNS effects have been reported with cimetidine including agitation, delirium, and confusion.
Frequency defined:
1%-10%
Headache
Dizziness
Drowsiness
Gynecomastia
Diarrhea
Frequency not defined:
Increased serum creatinine
Agitation
Anaphylaxis
Decreased white blood cell
Disorientation
Hepatic fibrosis
Anxiety
Hallucination
Hemolytic anemia
Pancytopenia
Urinary retention
Black Box Warning:
Important! If allergies affect you from cimetidine or acid reducers, avoid this product. Stop use immediately if swallowing food pains you, if vomiting blood, or if stools appear bloody or black – these signs demand doctor visit urgently. Also, never combine this product alongside other acid reducers. Following these warnings carefully protects your health from risks linked to this medication.
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration: </b>cimetidine falls under pregnancy category B.
Lactation: Not recommended for lactating females as it can be excreted in breast milk.
Pregnancy category:
Pharmacology:
Cimetidine is a medicine. It cuts down stomach acid. People take it for ulcers, heartburn, or acid reflux. You swallow tablets with water, as your doctor says.
Pharmacodynamics:
Cimetidine stops acid production in the stomach. It blocks H2-receptors in stomach cells. Histamine binds to these receptors and causes acid secretion. Cimetidine disrupts histamine binding, reducing stomach acid output. This helps with excessive acid conditions like reflux or ulcers. When H2-receptors are blocked, gastric juices decrease. By lowering acid, cimetidine treats stomach problems effectively. It moderates secretions through inhibiting these receptors. Therefore, cimetidine is useful for gastrointestinal disorders characterized by overactive stomach acid production.
Pharmacokinetics:
Absorption
The medicine is absorbed 60-70% into the body. Its effects peak in 45 minutes to 1.3 hours when taken by mouth. For shots, peak effects happen in 15 minutes.
Distribution
The drug binds 15-20% to proteins in the body. It spreads through 1 liter per kilogram in adults. In kids aged 1-12 years, it spreads through 2.13 liters per kilogram.
Metabolism
The liver breaks down the drug, stopping some enzymes from working.
Elimination and Excretion
In adults, half the drug leaves the body in 2 hours. For babies, half leaves in 2.1-3.6 hours. Only 2-3% exits through solid waste. Most, 48-75%, leaves through urine.
Administration:
Swallow the pills with water each day as instructed. If prescribed once daily, take it at bedtime. Never exceed the recommended frequency noted on the label. Stay on schedule and follow the instructions very carefully.
Patient information leaflet
Generic Name: cimetidine
Pronounced: sye MET i deen
Why do we use cimetidine?
Cimetidine is used to treat conditions caused by excessive stomach acid, such as heartburn, stomach ulcers, and gastroesophageal reflux disease (GERD). It works by reducing the production of acid in the stomach, helping to relieve symptoms and promote healing.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
