The Navigation Model of Therapy: Why Awareness Changes Everything
November 16, 2025
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Brand Name :
Declomycin
(United States) [Available]Synonyms :
demeclocycline
Class :
Antibiotics & Tetracycline derivatives
Brand Name :
Declomycin
(United States) [Available]Synonyms :
demeclocycline
Class :
Antibiotics & Tetracycline derivatives
Dosage forms & StrengthsÂ
Tablet, Oral:Â
150 mgÂ
300 mg Â
Note: Demeclocycline and other tetracycline drugs are used as an alternative treatment for infections where penicillins are contraindicated due to vast spectrum of action. Â
General dose for various bacterial infections:Â
150 mg 4 times a day orÂ
300 mg twice a dayÂ
Dosage forms & StrengthsÂ
Tablet, Oral:Â
150 mgÂ
300 mg Â
Note: The use of demeclocycline is uncommon and rare; alternative tetracyclines (doxycycline, minocycline) are recommended. Â
Children > 8 years and adolescents: 7 to 13 mg/kg every 6 to 12 hours per day (do not exceed 600 mg/day)Â
Refer to adult dosingÂ
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
may diminish the absorption when combined with tetracyclines
measles, mumps, rubella, and varicella vaccine, live (Rx)
may diminish the therapeutic effect
measles mumps and rubella vaccine, live
may diminish the therapeutic effect
may diminish the therapeutic effect
smallpox (vaccinia) vaccine, live
may diminish the therapeutic effect
may diminish the therapeutic effect
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
respiratory syncytial virus vaccine, adjuvanted
may decrease the therapeutic effect when combined with vaccine
respiratory syncytial virus (RSV) vaccine
may decrease the therapeutic effect when combined with vaccine
poliovirus vaccine, live, trivalent
may decrease the therapeutic effect when combined with vaccine
poliovirus vaccine inactivated
may decrease the therapeutic effect when combined with vaccine
may have an increased nephrotoxic effect when combined with aminoglycosides
neomycin/polymyxin B/bacitracin topical
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
magnesium salts may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
antacids may decrease the absorption of tetracyclines
may diminish the absorption of iron preparations
may diminish the serum concentration when combined with tetracyclines
may diminish the serum concentration when combined with tetracyclines
may diminish the absorption of magnesium salts
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may have a decreased absorption when combined with tetracyclines
may decrease the therapeutic effect when combined with bacillus clausii
sodium picosulfate, citric acid, and magnesium oxideÂ
may decrease the therapeutic effect when combined with sodium picosulfate
may decrease the therapeutic effect when combined with typhoid vaccine
antibiotics: they may decrease the therapeutic effect of sodium picosulfuric acid
aluminum hydroxide/magnesium carbonateÂ
may decrease the serum concentration of antacids
meningococcal A C Y and W-135 diphtheria conjugate vaccine
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
may decrease the therapeutic effect of Antibiotics
oral form of aluminum hydroxide inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
may enhance the toxic effects of demeclocycline
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
interaction of both drugs may lead to respiratory depression
demeclocycline may reduce the therapeutic effects of BCG vaccine
oral form of bismuth subsalicylate inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
oral form of calcium acetate inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
oral form of calcium carbonate inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
oral form of calcium chloride inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
oral form of calcium citrate inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
calcium gluconate inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
calcium iron inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
demeclocycline may reduce the therapeutic effects of cholera vaccine
demeclocycline enhances the effects of cisatracurium
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
ferric meltol inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
ferrous fumarate inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
ferrous gluconate inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
ferrous sulfate inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
iron dextran inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
iron sucrose inhibits the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
exhibit the risk of pseudotumor cerebri
it may inhibit the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
it may inhibit the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
it may inhibit the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
it may inhibit the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
it may inhibit the GI absorption of demeclocycline (provide 2 hours difference between both drugs)
it may increase risk of nephrotoxicity
it may enhance the photosensitizing effects of the other drug
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
interaction of both drugs may lead to respiratory depression
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
interaction of both drugs may lead to respiratory depression
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
interaction of both drugs may lead to respiratory depression
when both drugs are combined, there may be decrease in effect of demeclocycline by inhibition of gi absorption
bismuth subsalicylate reduces the levels of demeclocycline by inhibiting gastrointestinal absorption
lansoprazole amoxicillin and clarithromycin
when amoxicillin combines with demeclocycline it decreases the effects of action of drug by antagonism effect
amoxicillin and clavulanate potassium
when amoxicillin combines with demeclocycline it decreases the effects of action of drug by antagonism effect
omeprazole amoxicillin and clarithromycin
when both drugs are combined, there may be a decreased effect of the drug's action by antagonism effect
may diminish the absorption of magnesium salts
may decrease the therapeutic effect when combined with bcg
may decrease the therapeutic effect when combined with cholera vaccine
aluminum hydroxide/magnesium hydroxideÂ
may diminish the absorption of Antacids
antibiotics decrease the efficacy of BCG intravesical
it decreases the efficacy of antibiotics
may have a decreased therapeutic efficacy when combined with demeclocycline
demeclocycline may interfere with the intestinal flora and reduce the effects of conjugated estrogens (oral form of hormones)
demeclocycline reduces the effects of bactericidal agents
demeclocycline reduces the effects of bactericidal agents
demeclocycline reduces the effects of bactericidal agents
demeclocycline reduces the effects of bactericidal agents
demeclocycline reduces the effects of bactericidal agents
demeclocycline reduces the effects of bactericidal agents
cholestyramine reduces the therapeutic effects of demeclocycline by inhibiting GI absorption
didanosine reduces the therapeutic effects of demeclocycline by inhibiting GI absorption
demeclocycline may interfere with the intestinal flora and reduce the effects of digoxin
demeclocycline may interfere with the intestinal flora and reduce the effects of conjugated estrogens (oral form of hormones)
estrogens conjugated synthetic
demeclocycline may interfere with the intestinal flora and reduce the effects of conjugated estrogens (oral form of hormones)
demeclocycline may interfere with the intestinal flora and reduce the effects of conjugated estrogens (oral form of hormones)
demeclocycline may interfere with the intestinal flora and reduce the effects of conjugated estrogens (oral form of hormones)
it reduces the therapeutic effects of demeclocycline by inhibiting GI absorption
demeclocycline may interfere with the intestinal flora and reduce the effects of conjugated estrogens (oral form of hormones)
demeclocycline may interfere with the intestinal flora and reduce the effects of conjugated estrogens (oral form of hormones)
tetracycline reduces the therapeutic effects of methotrexate by suppressing GI metabolism by intestinal flora
increases the adverse toxic effects
increases the adverse toxic effects
demeclocycline enhances the therapeutic effects of warfarin
zinc may reduce the GI absorption and effects of demeclocycline
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
may enhance the risk of adverse effect of retinoic acid derivatives
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may reduce the therapeutic effect of penicillins
amoxicillin and clavulanate potassium
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may enhance the neuromuscular-blocking effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
They may diminish the absorption when combined with bile acid sequestrants
it may diminish the excretion rate when combined with tetracyclines, resulting in an enhanced serum level
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
sodium picosulfate, citric acid, and magnesium oxide
may diminish the effect of each other when combined
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
When demeclocycline is used together with calcium levulinate, this leads to a reduced concentration serum of demeclocycline
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
may increase the hypoglycemic effect of sulfonylureas
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may decrease the therapeutic effect when combined with lactobacillus and estriol
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the rate of absorption
may decrease the rate of absorption
may decrease the rate of absorption
may decrease the rate of absorption
may diminish the absorption of magnesium salts
BCG Vaccine live: they may decrease the therapeutic effect of antibiotics
may diminish the absorption when combined with tetracyclines
It may enhance the risk of adverse effects when combined with Tetracyclines
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
tetracyclines efficacy may be reduced when calcimax is used in combination
demeclocycline may enhance the therapeutic effects of antithrombin alfa
demeclocycline may enhance the therapeutic effects of antithrombin III
demeclocycline may enhance the therapeutic effects of argatoban
demeclocycline may decrease the therapeutic effects of the balsalazide
demeclocycline may decrease the therapeutic effects of the bemiparin
demeclocycline may decrease the therapeutic effects of the biotin
demeclocycline may increase the therapeutic effects of the bivalirudin
colestipol reduces the therapeutic effects of demeclocycline by affecting GI absorption
demeclocycline increases the effects of dalteparin by an unknown mechanism
demeclocycline increases the effects of enoxaparin by an unknown mechanism
demeclocycline increases the effects of fondaparinux by an unknown mechanism
demeclocycline increases the effects of heparin by an unknown mechanism
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
antibiotics decrease the efficacy of thiamine by altering the gut flora
Demeclocycline prevents cell division by blocking translation. It stops the amino acyl tRNA from attaching to the ribosome’s A site by binding (reversibly) to the 30S and 50S ribosomal subunits.Â
Since many tetracycline antibiotics might result in diabetes insipidus, their use in SIADH depends on this side effect.Â
Frequency not defined:Â Â
Esophageal ulcerÂ
Increased liver enzymesÂ
Visual disturbanceÂ
DysphagiaÂ
GlossitisÂ
NauseaÂ
VomitingÂ
DiarrheaÂ
HepatotoxicityÂ
Reversible and more frequent photosensitivity reactionÂ
Dose-related diabetes insipidus Â
Discoloration of teethÂ
Superinfection, monilialÂ
Â
NoneÂ
Contraindication:Â
HypersensitivityÂ
Caution:Â
PhotosensitivityÂ
Tooth and Bone EffectsÂ
Pregnancy and BreastfeedingÂ
HepatotoxicityÂ
Pregnancy considerations: demeclocycline can be assigned under pregnancy category D. Avoid during pregnancy.Â
Lactation: Demeclocycline can be excreted in breast milk and may cause tooth discoloration in infants. Avoid use during breastfeeding. Â
Pregnancy category:Â
The lipophilic nature of demeclocycline allows it to passively diffuse through bacterial membrane porin channels or readily cross cell membranes.Â
It is a bacteriostatic medication that inhibits the growth of microorganisms. It keeps effective blood levels longer than tetracycline because it is eliminated more gradually.Â
Demeclocycline is not a direct bactericidal agent while it is a bacteriostatic drug.Â
Administer 1 hour prior to or 2 hours after meals.Â
Avoid taking it with antacids, multivitamins, calcium or magnesium supplements, iron supplements, or milk.Â
Generic Name: demeclocyclineÂ
Why do we use demeclocycline?Â
Demeclocycline is used to treat lyme disease, acne, and bronchitis. Â
It is also indicated in management of urinary tract infections, gum disease, malaria.Â
It is effective in bacterial infections including gonorrhea and chlamydia.Â
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