Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Zoloft
Synonyms :
Sertralina, Sertralinum, Sertraline
Class :
Antidepressants and antianxiety drugs; Selective Serotonin Reuptake Inhibitors
Brand Name :
Zoloft
Synonyms :
Sertralina, Sertralinum, Sertraline
Class :
Antidepressants and antianxiety drugs; Selective Serotonin Reuptake Inhibitors
Dosing & UsageÂ
AdultÂ
Dosage Forms & StrengthsÂ
TabletÂ
25mgÂ
50mgÂ
100mgÂ
CapsuleÂ
150mgÂ
200mgÂ
Oral SolutionÂ
20mg/mlÂ
Tablets
Initially, 50 mg orally each day
Increase the dose by 25 mg at an interval of one week
Do not exceed 200 mg each day
Capsules
Do not utilize it to start over the treatment
It is only available in the form of 150 mg and 200 mg
For the initial dosage, utilize another sertraline HCl product
In patients who are taking 100 mg or 125 mg of different sertraline HCl products for a minimum of 1 week, start with capsules
150 mg or 200 mg orally each day is used as a recommended dose
Do not exceed more than 200 mg each day
Obsessive-Compulsive DisorderÂ
Tablets- Initially, 50 mg orally each day
Increase the dose by 25 mg/day every week
Do not exceed the dose of more than 200 mg orally each day
Capsule-Do not utilize it to start a treatment
It is only available in the form of 150 mg or 200 mg
For the initial dosage, utilize another sertraline HCl product
Patients who are receiving 100 mg or 125 mg of another sertraline HCl product start with capsules for a minimum of 1 week
25 mg orally each day as a tablet
May increase the dose by 25 mg weekly
Do not exceed the dose of more than 200 mg each day
Initially, 25 mg orally each day as a tablet
May increase the dose by 25 mg weekly
Do not exceed the dose of more than 200 mg each day
Posttraumatic Stress DisorderÂ
Indicated for the treatment of posttraumatic stress disorder (PTSD), panic disorder, and social anxiety disorder (SAD):
25 mg orally each day as a tablet
May increase the dose to 50 mg weekly
Do not exceed the dose of more than 200 mg each day
Dosage Forms & StrengthsÂ
TabletÂ
25mgÂ
50mgÂ
100mgÂ
CapsuleÂ
150mgÂ
200mgÂ
Oral SolutionÂ
20mg/mlÂ
Obsessive-Compulsive DisorderÂ
For 6-12 years- 25 mg, orally each day
For 12-17 years- 50 mg orally each day
Increase the dose by 50 mg/day every week
Do not exceed the dose of more than 200 mg orally each day
If drowsiness is experienced, give the dose in the evening
Dosage Forms & StrengthsÂ
TabletÂ
25mgÂ
50mgÂ
100mgÂ
CapsuleÂ
150mgÂ
200mgÂ
Oral SolutionÂ
20mg/mlÂ
Initially, 25 mg/day orally each day
Increase the dose by 25 mg every 2-3 days
Do not exceed the dose of more than 200 mg orally each day
In depression due to Alzheimer’s and dementia, initially 12.5 mg/day and then titrate every 1-2 weeks
Do not exceed more than 150-200 mg
May increase the hypoglycemic effect of each other when combined
the antiplatelet effect of NSAIDs can be increased with combined SSRIs
the antiplatelet effect of NSAIDs can be increased with combined SSRIs
the antiplatelet effect of NSAIDs can be increased with combined SSRIs
the antiplatelet effect of NSAIDs can be increased with combined SSRIs
the antiplatelet effect of NSAIDs can be increased with combined SSRIs
may have an increased antiplatelet effect when combined with NSAIDs
may have an increased antiplatelet effect when combined with NSAIDs
may increase the tachycardic effect of Alpha-/Beta-Agonists
acetaminophen/doxylamine/dextromethorphanÂ
may increase the serotonergic effect when combined
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
sertraline: they may diminish the serum concentration of CYP3A4 Inducers
sertraline: they may diminish the serum concentration of CYP3A4 Inducers
sertraline: they may diminish the serum concentration of CYP3A4 Inducers
sertraline: they may diminish the serum concentration of CYP3A4 Inducers
sertraline: they may diminish the serum concentration of CYP3A4 Inducers
May increase the hypoglycemic effect of each other when combined
meningococcal A C Y and W-135 diphtheria conjugate vaccine
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
CYP3A strong enhancers of the small intestine may reduce the bioavailability of sertraline
when used together, entrectinib and midostaurin both increase the QTc interval
when used together, encorafenib and midostaurin both increase the QTc interval
it increases the toxicity of SSRIs
it increases the toxicity of SSRIs
it increases the effect of SSRIs
it increases the effect of SSRIs
may increase the serotonergic effect of Monoamine Oxidase Inhibitors
may have an increased serotonergic effect when combined with selective serotonin reuptake inhibitors
may have an increased serotonergic effect when combined with selective serotonin reuptake inhibitors
may have an increased serotonergic effect when combined with selective serotonin reuptake inhibitors
may have an increased serotonergic effect when combined with selective serotonin reuptake inhibitors
may have an increased serotonergic effect when combined with selective serotonin reuptake inhibitors
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may enhance the hypoglycemic effect
may increase the antiplatelet effect
may increase the antiplatelet effect
may increase the antiplatelet effect
may increase the antiplatelet effect
may increase the antiplatelet effect
It may enhance the metabolism when combined with dexamethasone
selective serotonin reuptake inhibitors: they may increase the hypoglycemic effect of blood viscosity reducing agents
selective serotonin reuptake inhibitors: they may increase the hypoglycemic effect of blood viscosity reducing agents
selective serotonin reuptake inhibitors (A2): they may increase the hypoglycemic effect of blood viscosity reducing agents
selective serotonin reuptake inhibitors (A2): they may increase the hypoglycemic effect of blood viscosity reducing agents
may decrease the therapeutic effect when combined with radiopharmaceutical iobenguane products
may decrease the therapeutic effect when combined with radiopharmaceutical iobenguane products
may decrease the therapeutic effect when combined with radiopharmaceutical iobenguane products
may decrease the therapeutic effect when combined with radiopharmaceutical iobenguane products
may decrease the therapeutic effect when combined with radiopharmaceutical iobenguane products
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism  
it increases the effect or level of palbociclib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
may increase the antiplatelet effect
may increase the antiplatelet effect of nonsteroidal anti-inflammatory agents
may increase the hypoglycemic effect of blood glucose-lowering agents
may increase the toxic effect of antipsychotic agents
may increase the serotonergic effect of Serotonin 5-HT1D Receptor Agonists
may increase the serotonergic effect of Serotonin 5-HT1D Receptor Agonists
may enhance the effect of SSRI's
may enhance the effect of SSRI's
may enhance the effect of SSRI's
may enhance the effect of SSRI's
may enhance the effect of SSRI's
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
may enhance the risk of adverse effects
empagliflozin and linagliptinÂ
may increase the hypoglycaemic effect when combined
may increase the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
When acelofenac is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When acemetacin is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When acenocoumarol is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When acetylsalicylic acid is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When alteplase is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When aminophenazone is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When anagrelide is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When antipyrine is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When antrafenine is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When apixaban is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When ardeparin is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When benoxaprofen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When benzydamine is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When bivalirudin is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When caplacizumab is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When carprofen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When celecoxib is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When dalteparin is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When dantrolene is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When desirudin is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When dexibuprofen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When dexketoprofen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When dextran is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When diclofenac is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When dicoumarol is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When edoxaban is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When enoxaparin is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When etodolac is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When etoricoxib is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When fenbufen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When fluindione is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When flurbiprofen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When ibuprofen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When indomethacin is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When ketoprofen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When ketorolac is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When lornoxicam is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When loxoprofen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When meclofenamic acid is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When mefenamic acid is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When meloxicam is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When nadroparin is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When naproxen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When nepafenac is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When nimesulide is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When oxaprozin is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When parecoxib is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When pentoxifylline is used together with sertraline, the risk or seriousness of bleeding may be enhanced
It may enhance the risk of adverse effects when combined with calcium
Actions and Spectrum:Â
Sertraline selectively inhibits the reuptake of serotonin by presynaptic neurons in the central nervous system enhancing neurotransmission and mood improvement. Â
Its selective nature means it has minimal affinity for other neurotransmitter transporters resulting in lower adverse effects compared to other medications. Â
It is effective in treating depression, anxiety disorders, obsessive-compulsive disorder, post-traumatic stress disorder, and premenstrual dysphoric disorder.Â
Adverse Reaction Â
Frequency definedÂ
>10%Â
NauseaÂ
Dry mouth Â
Fatigue Â
Diarrhea/loose stools Â
Insomnia Â
Dizziness Â
Somnolence Â
1-10%Â
Tremor Â
Dyspepsia Â
Decreased appetite Â
Ejaculation failure Â
Agitation Â
Libido decreased Â
Constipation Â
Vomiting Â
Erectile dysfunction Â
Palpitations Â
Visual impairment Â
Ejaculation disorder Â
Male sexual dysfunctionÂ
<1%Â
TachycardiaÂ
TinnitusÂ
HematuriaÂ
AtaxiaÂ
Blurred visionÂ
AnaphylaxisÂ
ComaÂ
Muscle spasmsÂ
BronchospasmÂ
Black Box Warning:Â
It can lead to altered psychological behavior and suicidal thoughts, so it’s crucial to closely monitor all patients taking these medications for clinically worsened cases.Â
Contraindication/Caution:Â
Sertraline should not be used by individuals who are allergic to it have a monoamine oxidase inhibitor (MAOI) medication have liver disease, kidney disease, bleeding disorders, bipolar disorder, pregnant or breastfeeding, or in children and adolescents. Â
It is important to note that sertraline can increase the risk of serotonin syndrome, liver disease, renal impairment, bleeding disorders, bipolar disorder, pregnancy and breastfeeding, and children and adolescents. It should not be used within 14 days of discontinuing a MAOI medication as it can cause serotonin syndrome, worsen liver function and trigger manic episodes. Â
It is also important to be cautious during pregnancy and breastfeeding as sertraline may pass through breast milk and potentially harm the developing fetus or infant.Â
Pregnancy/Lactation Â
Pregnancy consideration: Â
sertraline should not be used during pregnancy Â
Breastfeeding warnings: Â
Use the drug cautiously during lactation.Â
Pregnancy category:Â
Pharmacology:Â
sertraline is an antidepressant drug for selective serotonin reuptake inhibitors (SSRIs). It works by increasing serotonin levels a neurotransmitter that regulates mood in the brain.Â
Pharmacodynamics:Â
Sertraline works by inhibiting the reuptake of serotonin in the brain increasing its concentration in the synaptic cleft between neurons. It is a neurotransmitter controlling sleep, mood, and appetite is believed to be an underlying cause of depression and mood disorders. It also affects other neurotransmitters like dopamine and norepinephrine but its effects on these are weaker than those on serotonin.Â
Pharmacokinetics:Â
AbsorptionÂ
The bioavailability is increased by the intake of foodÂ
The peak plasma concentration is achieved in 4.5-8.4 hrÂ
DistributionÂ
The protein-bound is 98%Â
MetabolismÂ
Hepatic cytochrome P450 enzymes metabolize the drugÂ
Minimal potent metabolites are formedÂ
Elimination and Excretion Â
The half-life is 26 hoursÂ
The drug is non-dialyzableÂ
The drug is excreted 12-14% in the urine and 40-45% in the feces Â
Administration:Â
Sertraline taken once daily either in the morning or evening with or without food. Â
The starting dose for depression and anxiety disorders is 50 mg daily which can be increased to 200 mg if needed. Â
For obsessive-compulsive disorder and the starting dose is 25 mg daily which can be increased to 200 mg if needed. Â
It is crucial to follow the medication label instructions and not stop taking sertraline abruptly or without consulting a healthcare provider.Â
Patient information leafletÂ
Generic Name:Â sertralineÂ
Pronounced: ser-tra-lineÂ
Why do we use sertraline?Â
sertraline is primarily used to treat major depressive disorder, anxiety disorders (such as panic disorder, social anxiety disorder, and generalized anxiety disorder), post-traumatic stress disorder, obsessive-compulsive disorder, and premenstrual dysphoric disorder.
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