A Game-Changer for Diabetes: Polymer Delivers Insulin Painlessly Through Skin
November 25, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Skelid
Synonyms :
Tiludronic acid, acido tiludronico, tiludronate, acidum tiludronicum, acide tiludronique
Class :
Antiresorptive/anti-inflammatory agent/ bisphosphonates
Brand Name :
Skelid
Synonyms :
Tiludronic acid, acido tiludronico, tiludronate, acidum tiludronicum, acide tiludronique
Class :
Antiresorptive/anti-inflammatory agent/ bisphosphonates
Dosage forms& Strengths
Tablets
200mg
antacids may reduce the absorption of quinolones
antacids may reduce the absorption of quinolones
antacids: they may diminish the bioavailability of corticosteroids
antacids: they may diminish the bioavailability of corticosteroids
antacids: they may diminish the bioavailability of corticosteroids
antacids: they may diminish the bioavailability of corticosteroids
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
may diminish the absorption when combined with iron preparations
may diminish the bioavailability when combined with corticosteroids
may diminish the bioavailability when combined with corticosteroids
may diminish the bioavailability when combined with corticosteroids
may diminish the bioavailability when combined with corticosteroids
may diminish the bioavailability when combined with corticosteroids
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
may diminish the effect of each other when combined
it may reduce the therapeutic effect of bisacodyl
it may decrease the serum concentration of belumosudil
may diminish the absorption of iron preparations
may diminish the bioavailability of corticosteroids
may diminish the absorption of quinolones
may diminish the serum concentration
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may reduce the rate of bioavailability of corticosteroids
may diminish the absorption when combined with quinolones
may diminish the absorption when combined with quinolones
cefuroxime: they may diminish the serum concentration of antacids
chloroquine: they may diminish the serum concentration of antacids
antacids: they may diminish the serum concentration of dabigatran
erlotinib: they may diminish the serum concentration of antacids
fosinopril: they may diminish the serum concentration of antacids
gefitinib: they may diminish the serum concentration of antacids
hyoscyamine: they may diminish the serum concentration of antacids
lanthanum carbonate: they may decrease the therapeutic effect of antacids
ledipasvir: they may diminish the serum concentration of antacids
nilotinib: they may diminish the serum concentration of antacids
pazopanib: they may diminish the serum concentration of antacids
potassium phosphate: they may diminish the serum concentration of antacids
riociguat: they may diminish the serum concentration of antacids
selpercatinib: they may diminish the serum concentration of antacids
sotalol: they may diminish the serum concentration of antacids
mesalamine: they may decrease the therapeutic effect of antacids
bosutinib: they may diminish the serum concentration of antacids
dasatinib: they may diminish the serum concentration of antacids
belumosudil: they may diminish the serum concentration of antacids
bismuth subgallate: they may decrease the therapeutic effect of antacids
bictegravir: they may decrease the therapeutic effect of antacids
cabotegravir: they may diminish the absorption of antacids
cefdinir: they may diminish the absorption of antacids
deferiprone: they may diminish the serum concentration of antacids
erdafitinib: they may diminish the serum concentration of antacids
pexidartinib: they may diminish the serum concentration of antacids
sotorasib: they may diminish the serum concentration of antacids
sparsentan: they may diminish the serum concentration of antacids
sulpiride: they may diminish the serum concentration of antacids
tetracyclins: they may diminish the serum concentration of antacids
velpatasvir: they may diminish the serum concentration of antacids
it may decrease the absorption of Levoketoconazole
antacids decrease the concentration of cefditoren in serum
they decrease the concentration of rilpivirine in the serum
they decrease the concentration of active metabolites of infigratinib in the serum
cefditoren: they may diminish the serum concentration of antacids
levonorgestrel: they may diminish the serum concentration of antacids
misoprostol: they may increase the toxic effect of antacids
antacids reduce the systemic absorption of phenothiazine derivatives
antacids reduce the systemic absorption of phenothiazine derivatives
antacids reduce the systemic absorption of phenothiazine derivatives
antacids reduce the systemic absorption of phenothiazine derivatives
antacids reduce the systemic absorption of phenothiazine derivatives
antacids may reduce the absorption of antipsychotic agents
antacids may reduce the absorption of antipsychotic agents
antacids may reduce the absorption of antipsychotic agents
antacids may reduce the absorption of antipsychotic agents
antacids may reduce the absorption of antipsychotic agents
l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
antacids may reduce the serum concentration of multivitamins
may reduce the bioavailability of corticosteroids
may reduce the bioavailability of corticosteroids
may reduce the bioavailability of corticosteroids
may reduce the bioavailability of corticosteroids
may reduce the bioavailability of corticosteroids
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the absorption of antipsychotic agents
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the bioavailability
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
antacids: they may diminish the absorption of calcium salts
antacids: they may diminish the absorption of calcium salts
antacids: they may diminish the absorption of calcium salts
antacids: they may diminish the absorption of calcium salts
antacids: they may diminish the absorption of calcium salts
antacids: they may decrease the therapeutic effect of laxative
antacids: they may decrease the therapeutic effect of laxative
antacids: they may decrease the therapeutic effect of laxative
antacids: they may decrease the therapeutic effect of laxative
sodium picosulfate, citric acid, and magnesium oxide
antacids: they may decrease the therapeutic effect of laxative
it may decrease the excretion of amphetamines
it may decrease the serum concentration of Atazanavir
antacids reduce the systemic absorption of isoniazid
may diminish the excretion of amphetamines
antacids decrease the efficacy of cysteamine
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
tetraferric tricitrate decahydrate
may decrease the serum concentration
may decrease the serum concentration
captopril: they may diminish the serum concentration of antacids
cefpodoxime: they may diminish the serum concentration of antacids
octreotide: they may diminish the serum concentration of antacids
levoketoconazole: they may diminish the absorption of antacids
rosuvastatin: they may diminish the serum concentration of antacids
This could lead to a reduction in concentration serum of mycophenolate
neratinib: they may diminish the serum concentration of antacids
isoniazid: they may diminish the absorption of antacids
the risk of anti-angiogenesis and jaw osteonecrosis may be increased
the risk of anti-angiogenesis and jaw osteoporosis may be increased
they decrease the concentration of active metabolites of infigratinib in the serum
Actions and spectrum:
Studies conducted in vitro have confirmed that the main effect of disodium tiludronate on bone is that it impedes osteoclastic activity, hence reducing enzymatic and transport processes linked to the dissolution of mineralized matrix. The degradation of the bone is achieved through the calls, activation, and polarization of the osteoclasts. Tiludronate disodium appears to be a product of osteoclast inhibition through at least the two pathways. The first one may be to destroy the cytoskeletal ring structure via inhibition of the protein-tyrosine-phosphatase kinase which results in detachment of osteoclasts from the bone surface, and lastly, it inhibits the osteoclastic proton pump.
Frequency defined
Nausea (9.3%)
Diarrhea (9.3%)
Dyspepsia (5.4%)
Frequency not defined
Anorexia
Urinary tract infections
Abdominal pain
Somnolence
Constipation
Dry mouth
Bronchitis
Vertigo
Syncope
Asthenia
Pruritis
Nervousness
Insomnia
Fatigue
Black box warning
The drug may cause irritation of the upper g.i.mucosa. Caution should be taken while prescribing the drug to patients with active gastrointestinal conditions.
Contraindications/Caution
Contraindications
Hypersensitivity
Unable to sit or stand for half an hour
Cautions
Osteonecrosis especially in the jaw
Severe renal impairment
Musculoskeletal pain
Pregnancy & breastfeeding:
Pregnancy consideration:
USFDA pregnancy category: C
Breastfeeding warnings:
Data about the excretion of the drug into breast milk is not known
Pregnancy category:
Pharmacology:
Tiludronic acid is a bisphosphonate compound which acts as an osteoregulator.
Pharmacodynamics:
Tiludronic acid is a drug of the bisphosphonate class that blocks the breakdown of bone by osteoclast cells. The long-term action is due to its slow removal from bones and has wide therapeutic index. Patients should be informed about the likelihood of developing gastric or duodenal ulcers, as well as damage to the upper digestive system mucosa.
Pharmacokinetics:
Absorption:
Cmax of 3.35±1.07mg/L can be reached in a Tmax of 1.7 to 0.9 hours after administration of a single dose of 400mg of the drug.
Distribution:
The estimated volume of distribution of the drug is known to be between 30L to 60L. 90% of the drug is known to be bound to proteins particularly to serum albumin.
Metabolism:
As per in vitro studies, the drug is not metabolized in the human liver.
Elimination and excretion:
60% of the drug is known to be eliminated in urine as unchanged drug.
Half-life: 150 hours
Administration:
This drug must be administered orally once daily with plenty of plain water.
Note: Patients must not lie down for at least half an hour after administration of the medicine.
This medicine should not be taken within two hours of taking food.
It should neither be given within two hours of administration of indomethacin.
Patient information leaflet
Generic Name: tiludronic acid
Why do we use tiludronic acid?
This is a first-generation bisphosphonate drug used in the treatment of Paget’s disease of bone. It is indicated in patients who have an abnormal level of serum alakaline phosphatase and those who are symptomatic and at risk of complications of the disease in mere future.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
