Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Hydrodiuril,hydro,esidrix,oretic,microzide
Synonyms :
Class :
Diuretics, thiazide
Brand Name :
Hydrodiuril,hydro,esidrix,oretic,microzide
Synonyms :
Class :
Diuretics, thiazide
Dosage Forms & Strengths
Oral tablet/capsule:
12.5mg,25mg,50mg
12.5 - 50
mg
Tablet
Orally
every 24 hours
25 - 100
mg
Tablet
Orally
twice a day
Dose Adjustments
Creatinine clearance: <10 ml/min-Avoid usage
Creatinine clearance: ≥10 ml/min-no dosage adjustment necessary
12.5mg-50mg orally every day
25-100mg orally once or twice a day
Dosage Forms & Strengths
Oral tablet/capsule:
12.5mg,25mg,50mg
1 - 3
mg/kg
Tablet
Orally
every 12 hrs
6
months
6 months-2 years:1-2mg/kg/day orally once a day
2-12 years: 1-3mg/kg/day
< 6 months:1-3 mg/kg/day orally every 12 hours
6 months-2 years:1-2mg/kg/day orally once a day
2-12 years: 1-3mg/kg/day
< 6 months:1-3 mg/kg/day orally every 12 hours
6 months years:1-3 mg/kg/day orally once a day
2-12 years: 1-3mg/kg/day
may increase the hypotensive effect of arsenic trioxide
may diminish the absorption of thiazide diuretics
may diminish the excretion of thiazide diuretics
may increase the adverse effect of thiazide diuretics
lithium: they may diminish the excretion when combined with thiazide
dofetilide: they may increase the QTc-prolonging effect when combined with thiazide
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may diminish the rate of excretion when combined
may diminish the rate of excretion when combined
may diminish the rate of excretion when combined
may diminish the rate of excretion when combined
may diminish the rate of excretion when combined
May enhance the toxic effects of the other by pharmacodynamic synergism
May enhance the toxic effects of the other by pharmacodynamic synergism
may increase toxicity of the drug by decreasing the renal clearance
May enhance the toxic effects of the other by pharmacodynamic synergism
may increase toxicity of the drug by decreasing the renal clearance
May enhance the toxic effects of the other by pharmacodynamic synergism
May enhance the effects of the other by pharmacodynamic synergism
May enhance the effects of the other by pharmacodynamic synergism
the toxicity of cyclophosphamide increases by decreasing renal clearance.
may increase the QTc-prolonging effect of thiazide diuretics
may increase the QTc-prolonging effect of hydrochlorothiazide
may diminish the therapeutic effect of antidiabetic Agents
may diminish the therapeutic effect of antidiabetic Agents
may diminish the therapeutic effect of antidiabetic Agents
may diminish the therapeutic effect of antidiabetic Agents
may diminish the therapeutic effect of antidiabetic Agents
corticosteroids may enhance the hypokalemic effect of Thiazide and thiazide-Like diuretics
corticosteroids may enhance the hypokalemic effect of Thiazide and thiazide-Like diuretics
corticosteroids may enhance the hypokalemic effect of Thiazide and thiazide-Like diuretics
corticosteroids may enhance the hypokalemic effect of Thiazide and thiazide-Like diuretics
corticosteroids may enhance the hypokalemic effect of Thiazide and thiazide-Like diuretics
may decrease the levels of serum potassium
may decrease the effects of the other by pharmacodynamic antagonism
may decrease the levels of serum potassium
May enhance the effects of the other by pharmacodynamic synergism
may decrease the levels of serum potassium
May enhance the effects of the other by pharmacodynamic synergism
May enhance the toxic effects of the other by pharmacodynamic synergism
may decrease the levels of serum potassium
May enhance the effects of the other by pharmacodynamic synergism
may decrease the levels of serum potassium
may decrease the levels of serum potassium
may decrease the levels of serum potassium
May enhance the effects of the other by pharmacodynamic synergism
may decrease the levels of serum potassium
may enhance the effect of the other by cationic drug competition for renal tubular clearance.
may decrease the levels of serum potassium
thiazides reduce the systemic absorption of calcium salts
thiazides reduce the systemic absorption of calcium salts
thiazides reduce the systemic absorption of calcium salts
thiazides reduce the systemic absorption of calcium salts
thiazides reduce the systemic absorption of calcium salts
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may increase the serum concentration
may decrease the therapeutic effect
may decrease the therapeutic effect
may decrease the therapeutic effect
may decrease the therapeutic effect
may decrease the therapeutic effect
they decrease the efficacy of antidiabetic agents
they decrease the efficacy of antidiabetic agents
they decrease the efficacy of antidiabetic agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
they increase the effect of neuromuscular blockage of neuromuscular-blocking agents
may diminish the therapeutic effect of antidiabetic agents
may diminish the therapeutic effect of antidiabetic agents
may diminish the therapeutic effect of antidiabetic agents
may enhance the adverse/toxic effect of cardiac glycosides
may enhance the adverse/toxic effect of cardiac glycosides
may enhance the adverse/toxic effect of cardiac glycosides
may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents
may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents
may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents
may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents
may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may have an increased hypercalcemic effect when combined with vitamin D analogs
may reduce the therapeutic effect
It may diminish the therapeutic efficacy when combined with pegloticase
It may enhance toxicity when combined with beclomethasone, inhaled by enhancing elimination
It may enhance the effects when combined with vitamin D
thiazides: they may decrease the therapeutic effect when combined with antidiabetic drugs
thiazide: they may enhance the serum concentration when combined with calcium salts
thiazide: they may enhance the serum concentration when combined with calcium salts
thiazide: they may enhance the serum concentration when combined with calcium salts
thiazide: they may enhance the serum concentration when combined with calcium salts
thiazide: they may enhance the serum concentration when combined with calcium salts
hypokalemic effects of thiazide-like derivatives can be increased with beta2 agonists
hypokalemic effects of thiazide-like derivatives can be increased with beta2 agonists
hypokalemic effects of thiazide-like derivatives can be increased with beta2 agonists
hypokalemic effects of thiazide-like derivatives can be increased with beta2 agonists
hypokalemic effects of thiazide-like derivatives can be increased with beta2 agonists
lansoprazole amoxicillin and clarithromycin
when amoxicillin combines with hydrochlorothiazide it decreases the effects of the action of drug by decreasing renal clearance
amoxicillin and clavulanate potassium
when amoxicillin combines with hydrochlorothiazide it decreases the effects of the action of drug by decreasing renal clearance
omeprazole amoxicillin and clarithromycin
when both drugs are combined, there may be a decreased effect of the drug's action by decreasing renal clearance
when both drugs are combined, there may be a decreased effect of the drug's action by decreasing renal clearance
Thiazides may increase the hypokalemic effect of Dichlorphenamide
may decrease the serum potassium levels
may increase the hypercalcaemic effect
may increase the toxic effects of opioid agonists
may enhance the hypotensive effect of ACE Inhibitors
may enhance the hypotensive effect of ACE Inhibitors
may enhance the hypotensive effect of ACE Inhibitors
may enhance the hypotensive effect of ACE Inhibitors
may enhance the hypotensive effect of ACE Inhibitors
may increase the serum concentration of thiazide and thiazide-Like diuretics
may increase the serum concentration of thiazide and thiazide-Like diuretics
may increase the serum concentration of thiazide and thiazide-Like diuretics
may increase the serum concentration of thiazide and thiazide-Like diuretics
may increase the serum concentration of thiazide and thiazide-Like diuretics
may increase the orthostatic hypotensive effect of thiazide diuretics
may increase the allergic or hypersensitivity reactions to thiazide diuretics
calcium, magnesium, potassium and sodium oxybate
may diminish the calcium salts excretion
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypercalcemic effect
may increase the hypokalemic effect of beta2 agonists
may increase the hypokalemic effect of beta2 agonists
may increase the serum concentration of anticholinergic agents
may decrease the therapeutic effect of Antidiabetic Agents
may increase the serum concentration of Anticholinergic Agents
may increase the serum concentration of Anticholinergic Agents
may enhance the serum concentration of Anticholinergic Agents
may have an increased hypercalcemic effect when combined with Vitamin D and its analogs
diazoxide may enhance the adverse/toxic effect of thiazides
may increase the hypercalcemic effect when combined
Beta2-Agonists: they mayincrease the hypokalemic effect when combined with thiazides
Beta2-Agonists: they mayincrease the hypokalemic effect when combined with thiazides
Beta2-Agonists: they mayincrease the hypokalemic effect when combined with thiazides
Beta2-Agonists: they mayincrease the hypokalemic effect when combined with thiazides
Beta2-Agonists: they mayincrease the hypokalemic effect when combined with thiazides
corticosteroids: they may increase the hypokalemic effect when combined with thiazides
corticosteroids: they may increase the hypokalemic effect when combined with thiazides
corticosteroids: they may increase the hypokalemic effect when combined with thiazides
corticosteroids: they may increase the hypokalemic effect when combined with thiazides
corticosteroids: they may increase the hypokalemic effect when combined with thiazides
cyclophosphamide: they may increase the toxic effect when combined with thiazides
dichlorphenamide: they may increase the hypokalemic effect when combined with thiazides
licorice: they may increase the hypokalemic effect when combined with thiazides
ivabradine: they may increase the arrhythmogenic effect when combined with thiazides
methenamine: they may decrease the therapeutic effect when combined with thiazides
nonsteroidal anti-inflammatory agents: they may decrease the therapeutic effect when combined with thiazides
nonsteroidal anti-inflammatory agents: they may decrease the therapeutic effect when combined with thiazides
nonsteroidal anti-inflammatory agents: they may decrease the therapeutic effect when combined with thiazides
nonsteroidal anti-inflammatory agents: they may decrease the therapeutic effect when combined with thiazides
nonsteroidal anti-inflammatory agents: they may decrease the therapeutic effect when combined with thiazides
reboxetine: they may increase the hypokalemic effect when combined with thiazides
toremifene: they may increase the hypercalcemic effect when combined with thiazides
may increase the hypokalemic effect of Beta2-Agonists
may enhance the serum concentration of Anticholinergic Agents
may increase the hypokalemic effect of thiazide diuretics
when thiazides are used concominantly with calcimax syrup, there is an increased risk of calcium levels in the blood
when thiazides are used concominantly with calcimax syrup, there is an increased risk of calcium levels in the blood
when thiazides are used concominantly with calcimax syrup, there is an increased risk of calcium levels in the blood
when thiazides are used concominantly with calcimax syrup, there is an increased risk of calcium levels in the blood
when thiazides are used concominantly with calcimax syrup, there is an increased risk of calcium levels in the blood
may enhance the effect of the other by cationic drug competition for renal tubular clearance
may enhance the effect of the other by cationic drug competition for renal tubular clearance
May enhance the effects of the other by pharmacodynamic synergism
may enhance the effect of the other by cationic drug competition for renal tubular clearance
May diminish the effects of pharmacodynamic antagonism
hydrochlorothiazide increases the effect of piperacillin by decreasing renal clearance.
increase hepatotoxicity due to decreased elimination
increase hepatotoxicity due to decreased elimination
Frequency undefined:
Anorexia
Disorder of hematopoietic structure
Epigastric distress
Headache
Hepatotoxicity
Hypercalcemia
Hypercholesterolemia
Interstitial nephritis
Hypotension
Metabolic acidosis
Phototoxicity
Pulmonary edema
Stevens-Johnson syndrome
Vertigo
Xanthopsia
Purpura
Muscle weakness or cramps
Nausea
Pancreatitis
Respiratory distress
Post marketing complications:
Non-melanoma skin cancer
Myopia
Be cautious of Electrolyte disturbances. It may cause systemic lupus exacerbation.
Pregnancy consideration:
The drug doesn’t cause significant harm.
Pregnancy category: B
Lactation: The drug is excreted in the human breast milk
Pregnancy category:
Patient information leaflet
Generic Name: hydrochlorothiazide
Pronounced: [ HYE-dro-KLOR-o-THY-a-zide ]
Why do we use hydrochlorothiazide?
Hydrochlorothiazide belongs to the class of thiazide diuretics, which helps prevent the body from absorbing too much salt, which causes fluid retention. It is also used to treat hypertension.
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