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Brand Name :
Oxpam, Serax
Synonyms :
oxazepam
Class :
Antianxiety Agents, Anxiolytics, Benzodiazepines
Brand Name :
Oxpam, Serax
Synonyms :
oxazepam
Class :
Antianxiety Agents, Anxiolytics, Benzodiazepines
Dosage Forms & StrengthsÂ
CapsuleÂ
10 mgÂ
15 mgÂ
30 mgÂ
The usual dose for mild to moderate anxiety is 10 to 15 mg. For severe anxiety and related syndromes, it is 15 to 30 mg via oral administration given or taken three times or maybe four times per day
Conditions associated with mild to moderate and severe anxiety and its associated symptoms are tension, agitation, irritability, and symptoms related secondary to organic disease, depression
The usual dose for treating alcohol withdrawal is 15 to 30 mg via oral administration given or taken three or four times a day
Conditions associated with this dose are relief in alcoholic patients with acute intoxication, anxiety upon withdrawal, and tremulousness
In children 13 years or older, the usual dose for managing mild to moderate anxiety is 10 to 15 mg via oral administration given or taken three or four times a day. For severe anxiety, the usual dose is 15 to 30 mg via oral administration, given three or four times a day. The same dose is used for associated symptoms of anxiety such as irritability, agitation, tension, symptoms related secondary to organic disease, and depression.Â
Safety and efficacy below 13 are not established.Â
The usual dose is 10 mg via oral administration given or taken thrice daily. It can be raised to 15 mg with caution, that is, via oral administration three or four times a day. Conditions associated with this dose are for managing anxiety, irritability, agitation, and tension.Â
The usual dose is 10 mg via oral administration given or taken thrice daily. It can be raised to 15 mg with caution, that is, via oral administration three or four times a day
Conditions associated with this dose are for managing anxiety, irritability, agitation, and tension
may enhance the risk of CNS depression when combined with each other
may enhance the risk of CNS depression when combined with each other
may enhance the risk of CNS depression when combined with each other
may enhance the risk of CNS depression when combined with each other
may enhance the risk of CNS depression when combined with each other
may enhance the risk of CNS depression when combined with each other
may enhance the risk of CNS depression when combined with each other
may enhance the risk of CNS depression when combined with each other
may have an increased effect of a CNS depressant when combined with opioid agonists
may have an increased effect of a CNS depressant when combined with opioid agonists
The interaction may increase the risk of sedation, respiratory depression, and coma
CNS depressants may increase the CNS depressant effect
may have an increased cns depressive effect when combined with zolpidem
may have an increased CNS depressant effect when combined with oxycodone
may have an increasingly adverse effect when combined with ropeginterferon alfa-2b
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
flunitrazepam: they may increase the CNS depressant effect of CNS Depressants
buprenorphine,long-acting injectionÂ
may increase the CNS depressant effect of Buprenorphine
may have an increased Effect of a CNS depressant when combined with blonanserin
may increase the risk of CNS depression when combined with 1,2-Benzodiazepine
hydroxyzine: they may increase the CNS depressant effect of CNS Depressants
methotrimeprazine: they may increase the CNS depressant effect of CNS Depressants
clozapine: they may increase the toxic effect of benzodiazepines
clozapine: they may increase the CNS depressant effect of CNS Depressants
secretin: they may increase the CNS depressant effect of CNS Depressants
combining CNS depressants with propoxyphene may result in an additive CNS depression
alvimopan: it may increase the risk of CNS depression
benorilate: it may increase the risk of CNS depression
amobarbital: it may decreased the serum concentration of CNS depressants
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
it increases the effect of CNS depressants
it increases the effect of CNS depressants
CNS depressants increase the effect of orphenadrine
it increases the effect of CNS depressants
it increases the efficacy of CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with orphenadrine
may have an increased CNS depressive effect when combined with paraldehyde
may have an increased CNS depressive effect when combined with thalidomide
it increases the effect of CNS depressants
may have an increased CNS depressant effect when combined with flunarizine
azelastine: they may increase the CNS depressant effect of CNS Depressants
olopatadine (Nasal): they may increase the CNS depressant effect of CNS Depressants
azelaic acid: they may increase the CNS depressant effect of CNS Depressants
ipratropium: they may increase the CNS depressant effect of CNS Depressants
naltrexone: they may increase the CNS depressant effect of CNS Depressants
may increase the efficacy of each other when combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the risk of adverse effect of other CNS depressants
may increase the risk of adverse effect of other CNS depressants
may increase the risk of adverse effect of other CNS depressants
may increase the risk of adverse effect of other CNS depressants
may increase the risk of adverse effect of other CNS depressants
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the tachycardic effect
may enhance the tachycardic effect
The potential for increased CNS depression risk or seriousness occurs when oxazepam is used together with pipecuronium
may have an increased CNS depressant effect when combined with alcohol
nabilone and oxazepam, when used simultaneously, both increase the sedation
perampanel may enhance the CNS depressant effect of CNS Depressants
may increase the risk of adverse effect of other CNS depressants
may increase the risk of adverse effect of other CNS depressants
may increase the risk of adverse effect of other CNS depressants
may increase the risk of adverse effect of other CNS depressants
may increase the risk of adverse effect of other CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may increase the toxic effect of CNS depressants
it decreases the efficacy of antianxiety agents
may increase the toxic effect of CNS depressants
promethazine/dextromethorphanÂ
may increase the toxic effect of other CNS Depressants
may have an increased CNS depressant effect when combined with CNS depressants
CNS depressants increase the CNS depressing effect of brexanolone
it increases the effect of CNS depressants
ixabepilone: they may increase the CNS depressant effect of CNS Depressants
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may have an increased Effect of a CNS depressant when combined with CNS depressants
it may diminish the excretion rate when combined with benzodiazepines, resulting in an enhanced serum level
it may diminish the excretion rate when combined with benzodiazepines, resulting in an enhanced serum level
it may diminish the excretion rate when combined with benzodiazepines, resulting in an enhanced serum level
it may diminish the excretion rate when combined with benzodiazepines, resulting in an enhanced serum level
it may diminish the excretion rate when combined with benzodiazepines, resulting in an enhanced serum level
it increases the toxicity of CNS depressants
CNS depressants increase the effect of sedation of pramipexole
kava: they may increase the CNS depressant effect of CNS Depressants
levothyroxine: they may increase the CNS depressant effect of CNS Depressants
perampanel: they may increase the CNS depressant effect of CNS Depressants
metyrosine: they may increase the CNS depressant effect of CNS Depressants
dasatinib: they may increase the CNS depressant effect of CNS Depressants
nitroglycerin: they may increase the CNS depressant effect of CNS Depressants
ramosetron: they may increase the CNS depressant effect of CNS Depressants
arginine: they may increase the CNS depressant effect of CNS Depressants
diacerein: they may increase the CNS depressant effect of CNS Depressants
aliskiren: they may increase the CNS depressant effect of CNS Depressants
molsidomine: they may increase the CNS depressant effect of CNS Depressants
naftopidil: they may increase the CNS depressant effect of CNS Depressants
urokinase: they may increase the CNS depressant effect of CNS Depressants
the soothing effect given by benzodiazepines is increased when sued in combination with melatonin
adverse or side effects associated with olanzapine can be increased with benzodiazepines
acebutolol: it may decrease the excretion rate of abacavir CNS depressant
aceclofenac: it may decrease the excretion rate of abacavir CNS depressant
acemetacin: it may decrease the excretion rate of abacavir CNS depressant
acenocoumarol: it may decrease the excretion rate of abacavir CNS depressant
acetohexamide: it may decrease the excretion rate of abacavir CNS depressant
alefacept: it may decrease the excretion rate of abacavir CNS depressant
allopurinol: it may decrease the excretion rate of abacavir CNS depressant
bacitracin: it may decrease the excretion rate of abacavir CNS depressant
baricitinib: it may decrease the excretion rate of abacavir CNS depressant
benazepril: it may decrease the excretion rate of abacavir CNS depressant
benserazide: it may decrease the excretion rate of abacavir CNS depressant
carboplatin: it may increase the risk or severity of CNS depression
bedaquiline: it may increase the risk or severity of CNS depression
agomelatine: it may increase the risk or severity of CNS depression
metocurine: it may increase the risk or severity of CNS depression
amoxicillin: it may increase the risk or severity of CNS depression
benzylpenicillin: it may increase the risk or severity of CNS depression
amphetamine: it may decreased the serum concentration of CNS depressants
cenobamate: it may increase the metabolism of CNS depressants
chlordiazepoxide: it may increase the metabolism of CNS depressants
pergolide: it may increase the risk of CNS depression
this preparation contains diphenhydramine and may enhance the impact of alcohol and other central nervous system depressants, including opioid analgesics, anticonvulsants, antihistamines, antidepressants, antiemetics, anxiolytic sedatives, antipsychotics, and hypnotics
may enhance the absorption of each other when combined
may enhance the absorption of each other when combined
may enhance the absorption of each other when combined
may enhance the absorption of each other when combined
may enhance the absorption of each other when combined
it increases the effect of CNS depressants
CNS depressants increase the effect of buprenorphine
it increases the effect of CNS depressants
it increases the effect of CNS depressants
CNS depressants increase the effect of suvorexant
Actions and Spectrum:Â
Actions:Â
Benzodiazepines will boost the GABA chemical in our brain, which can slow down CNS and help us feel calm.Â
Spectrum:Â
oxazepam is a benzodiazepine drug used to manage mild to severe anxiety and its associated symptoms of depression, tension, irritability, agitation, and tension. In alcoholic patients, this is used to treat withdrawal symptoms.Â
Frequency Not Defined Â
NauseaÂ
SyncopeÂ
Urinary IncontinenceÂ
Decreased libidoÂ
EdemaÂ
HypotensionÂ
UrticariaÂ
RashÂ
Menstrual diseaseÂ
LeukopeniaÂ
TremorÂ
Paradoxical CNS stimulationÂ
Blurred visionÂ
Fixed drug eruptionÂ
Hematologic diseaseÂ
DiplopiaÂ
Paradoxical excitationÂ
Black Box Warning:Â
While on this medication, patients should be cautious with driving or operating machinery because the drug will cause drowsiness or dizziness. Cautious with alcoholic patients who are on these medications.Â
Contraindication/Caution:Â
ContraindicationsÂ
CautionsÂ
Pregnancy consideration:Â Â
No data is available regarding the administration of the drug during pregnancy.Â
Breastfeeding warnings:Â Â
Not recommended.Â
Pregnancy category:Â
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: No data is available for the drug under this category.Â
Pharmacology:Â
Benzodiazepines will boost the GABA chemical in our brain, which can slow down CNS and help us feel calm.Â
Pharmacodynamics:Â
The sedation and anxiolytic action of oxazepam benzodiazepine boosts the activity of GABA chemical in the brain, which results in the body’s relaxation. Â
Pharmacokinetics:Â
AbsorptionÂ
It is absorbed slowly from GITÂ
The time to achieve peak effect is 3 hoursÂ
DistributionÂ
Protein-bound is 96-98%Â
The volume of distribution of oxazepam is 0.6-2 L/kgÂ
MetabolismÂ
oxazepam is metabolized to inactive metabolite benzophenone by hepatic glucuronide conjugation.Â
Elimination and ExcretionÂ
The half-life is 8 hours.Â
The drug is excreted in urine. Â
Administration:Â
This drug can be taken with or without meals, and be cautious with patients whose mental health is poor and with alcoholic patients.Â
Patient information leafletÂ
Generic Name: oxazepamÂ
Pronounced: ox-A-ze-pamÂ
Why do we use oxazepam?Â
It is a benzodiazepine which is used for treating anxiety disorders and alcohol withdrawal.Â
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