A Game-Changer for Diabetes: Polymer Delivers Insulin Painlessly Through Skin
November 25, 2025
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Brand Name :
Ultiva
Synonyms :
remifentanil
Class :
Opioids (narcotic analgesics)
Brand Name :
Ultiva
Synonyms :
remifentanil
Class :
Opioids (narcotic analgesics)
Dosage Forms & Strengths Â
Powder for injectionÂ
(1mg, 2mg, 3mg) per vial Â
Indicated for Anesthesia Induction
0.5-1 mcg/kg per minute IV; may be increased up to 1 mcg/kg per minute
Indicated for Anesthesia Maintenance
0.25-0.5 mcg/kg per minute; and for every 2-5 minutes 0.5-1 mcg/kg bolus in response to light anaesthesia
Indicated for Conscious Analgesia
1 mcg/kg IV bolus, followed by 0.05-0.2 mcg/kg per minute IV
Indicated for Post-Operative Period :
0.025-0.2 mcg/kg per minute IV
Dosage Forms & Strengths Â
Powder for injectionÂ
(1mg, 2mg, 3mg) per vial Â
Indicated for Maintenance:
Age: 2 months
0.4 mcg/kg per minute IV with Nitrous Oxide
Age: 1-12 years
0.25 mcg/kg per minute IV halothane, sevoflurane, & isoflurane
0.05-1.3 mcg/kg per minute IV, with a supplemental dose of 1 mcg/kg given over 30-60 secs IV
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
may have an increased CNS depressant effect when combined with opioid agonists
may enhance the serum concentration
may increase the CNS depressant effect
may increase the CNS depressant effect of CNS depressants
acrivastine and pseudoephedrineÂ
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may have an increased CNS depressive effect when combined with opioid agonists
may have an increased CNS depressive effect when combined with opioid agonists
may have an increased CNS depressive effect when combined with opioid agonists
may have an increased CNS depressive effect when combined with opioid agonists
may have an increased CNS depressive effect when combined with opioid agonists
may have an increasingly adverse effect when combined with alvimopan
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
promethazine/dextromethorphanÂ
may increase the CNS depressant effect of CNS Depressants
may increase the adverse effect of Monoamine Oxidase Inhibitors
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS Depressants
acetaminophen/doxylamine/dextromethorphanÂ
may increase the CNS depressant effect CNS Depressants
may increase the toxic effect of each other when combined
nalmefene: they may decrease the therapeutic effect of opioid drug
CNS stimulants: they may increase the CNS stimulant effect of opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of opioid drugs
may have an increased Effect of CNS depressant when combined with serotonergic opioids
may enhance the serum concentration of each other when it is combined
may enhance the serum concentration of each other when it is combined
may enhance the serum concentration of each other when it is combined
may enhance the serum concentration of each other when it is combined
may enhance the serum concentration of each other when it is combined
may enhance the severity of adverse effects when combined
may enhance the severity of adverse effects when combined
may enhance the severity of adverse effects when combined
may enhance the severity of adverse effects when combined
may enhance the severity of adverse effects when combined
they increase the efficacy of other opioid agonists
they increase the efficacy of other opioid agonists
they increase the efficacy of other opioid agonists
they increase the efficacy of other opioid agonists
may diminish the analgesic effect when combined with opioid agonists
may diminish the analgesic effect when combined with opioid agonists
may diminish the analgesic effect when combined with opioid agonists
may diminish the analgesic effect when combined with opioid agonists
may decrease the analgesic effect when combined with opioid agonists
may decrease the analgesic effect when combined with opioid agonists
they increase the efficacy of other opioid agonists
they increase the efficacy of other opioid agonists
they increase the efficacy of other opioid agonists
they increase the efficacy of other opioid agonists
they increase the toxicity of opioid agonists
they increase the toxicity of opioid agonists
they increase the toxicity of opioid agonists
they increase the toxicity of opioid agonists
they increase the toxicity of opioid agonists
may decrease the analgesic effect of opioids
may have an increased constipating effect when combined with eluxadoline
may decrease the therapeutic effect when combined with opioid agonists
methylnaltrexone: they may increase the adverse effect of opioid antagonists
samidorphan: they may decrease the therapeutic effect of opioid agonists
may decrease the therapeutic effect of Nalmefene
may diminish the analgesic effect when combined with opioid agonists
may diminish the analgesic effect when combined with opioid agonists
may diminish the analgesic effect when combined with opioid agonists
may diminish the analgesic effect when combined with opioid agonists
may enhance the adverse/toxic effect of diuretics
may enhance the adverse/toxic effect of diuretics
may enhance the adverse/toxic effect of diuretics
may enhance the adverse/toxic effect of diuretics
may enhance the adverse/toxic effect of diuretics
may reduce the therapeutic effect of gastrointestinal agents
may reduce the therapeutic effect of gastrointestinal agents
may reduce the therapeutic effect of gastrointestinal agents
may reduce the therapeutic effect of gastrointestinal agents
may reduce the therapeutic effect of gastrointestinal agents
anticholinergic agents increase the toxicity of opioid agents
anticholinergic agents increase the toxicity of opioid agents
anticholinergic agents increase the toxicity of opioid agents
anticholinergic agents increase the toxicity of opioid agents
anticholinergic agents increase the toxicity of opioid agents
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
spironolactone and hydrochlorothiazide
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
spironolactone and hydrochlorothiazide
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
acetaminophen/dextromethorphan/pseudoephedrine/guaifenesin
it may diminish the excretion rate when combined with analgesics, resulting in an enhanced serum level
acetaminophen, pheniramine, and phenylephrine
it may diminish the excretion rate when combined with analgesics, resulting in an enhanced serum level
may have an increased analgesic effect when combined with opioid agonists
may have an increased analgesic effect when combined with opioid agonists
may have an increased analgesic effect when combined with opioid agonists
may have an increased analgesic effect when combined with opioid agonists
may have an increased analgesic effect when combined with opioid agonists
opioid drugs: they may enhance the serum concentration of CYP2D6 Inhibitors
opioid drugs: they may enhance the serum concentration of CYP2D6 Inhibitors
opioid drugs: they may enhance the serum concentration of CYP2D6 Inhibitors
opioid drugs: they may enhance the serum concentration of CYP2D6 Inhibitors
opioid drugs: they may enhance the serum concentration of CYP2D6 Inhibitors
opioid drugs: they may increase the sedative effect of CNS stimulants
opioid drugs: they may increase the sedative effect of CNS stimulants
opioid drugs: they may increase the sedative effect of CNS stimulants
opioid drugs: they may increase the sedative effect of CNS stimulants
opioid drugs: they may increase the sedative effect of CNS stimulants
may enhance the CNS depressant effect of Opioid Agonists
may enhance the CNS depressant effect of Opioid Agonists
may enhance the CNS depressant effect of Opioid Agonists
may enhance the CNS depressant effect of Opioid Agonists
may enhance the CNS depressant effect of Opioid Agonists
may enhance the risk of adverse effect of Opioid agonists
may enhance the risk of adverse effect of Opioid agonists
may enhance the risk of adverse effect of Opioid agonists
may enhance the risk of adverse effect of Opioid agonists
may enhance the risk of adverse effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may decrease the therapeutic effect of anticholinergic agents
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may increase the toxic effect of Anticholinergic Agents
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
pegvisomant: they may decrease the therapeutic effect of opioid agonists
ramosetron: they may increase the constipating effect of opioid drugs
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the risk of adverse effects of opioid agonists
may increase the risk of adverse effects of opioid agonists
may increase the risk of adverse effects of opioid agonists
may increase the risk of adverse effects of opioid agonists
may increase the risk of adverse effects of opioid agonists
may increase the risk of adverse effects of opioid agonists
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
may increase the analgesic effect of opioid agonists
may increase the analgesic effect of opioid agonists
may increase the analgesic effect of opioid agonists
may increase the analgesic effect of opioid agonists
may increase the analgesic effect of opioid agonists
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may enhance the levels of serum concentration
may enhance the levels of serum concentration
may enhance the levels of serum concentration
may enhance the levels of serum concentration
may enhance the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may enhance the effect of serotonergic activity
may enhance the effect of serotonergic activity
may enhance the effect of serotonergic activity
may enhance the effect of serotonergic activity
may enhance the effect of serotonergic activity
may enhance the effect of serotonergic activity
may enhance the effect of serotonergic activity
may enhance the effect of serotonergic activity
may enhance the effect of serotonergic activity
may enhance the effect of serotonergic activity
may have an increasingly adverse effect when combined with opioid agonists
may have an increasingly adverse effect when combined with opioid agonists
may have an increasingly adverse effect when combined with opioid agonists
may have an increasingly adverse effect when combined with opioid agonists
may have an increasingly adverse effect when combined with opioid agonists
amphetamines: they may increase the analgesic effect of opioid drugs
desmopressin: they may increase the toxic effect of opioid drugs
nitric oxide: they may increase the toxic effect of opioid drugs
succinylcholine: they may increase the bradycardic effect of opioid drugs
may have an increasingly adverse effect when combined with opioid agonists
may diminish the analgesic effect when combined with opioid agonists
may diminish the analgesic effect when combined with opioid agonists
spironolactone and hydrochlorothiazide
may increase the adverse/toxic effect of diuretics
may increase the adverse/toxic effect of diuretics
may increase the adverse/toxic effect of diuretics
may increase the adverse/toxic effect of diuretics
may increase the adverse/toxic effect of diuretics
CYP3A4 inducers decrease the concentration of opioids
CYP3A4 inducers decrease the concentration of opioids
CYP3A4 inducers decrease the concentration of opioids
CYP3A4 inducers decrease the concentration of opioids
CYP3A4 inducers decrease the concentration of opioids
CNS depressants increase the effect of opioid agonists
CNS depressants increase the effect of opioid agonists
CNS depressants increase the effect of opioid agonists
CNS depressants increase the effect of opioid agonists serotonergic opioids
CNS depressants increase the effect of opioid agonists serotonergic opioids
CNS depressants increase the effect of opioid agonists serotonergic opioids
tricyclic antidepressants increase the CNS depression effect of serotonergic opioids
Adverse drug reactions Â
Frequency Defined Â
>10% Â
Vomiting Â
Nausea Â
1-10% Â
Skeletal muscle rigidity Â
Hypotension Â
Bradycardia  Â
Hypertension Â
Respiratory depression Â
Tachycardia Â
Pregnancy warnings:   
AU TGA pregnancy category: C
US FDA pregnancy category: Not AssignedÂ
Lactation: Â
Excreted into human milk is unknown Â
Pregnancy Categories:       Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.  Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were no enough studies on pregnant women. Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category Â
Patient Information Leaflet   Â
Generic Name: remifentanilÂ
Why do we use remifentanil? Â
remifentanil is an Opioids (narcotic analgesics) used to treat or prevent pain during and after surgery.Â
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