heparin

Brand Name :

Heparin Lock Flush (obsolete), Hep-Lock (obsolete), Hep-Pak (obsolete), Hep-Pak CVC (obsolete), Heparin Sodium ADD (Vantage) 

Synonyms :

heparin

Class :

Anticoagulants, Hematologic; Anticoagulants, Cardiovascular 

Mail Whatsapp PDF Image

No data available for drug.

Actions and Spectrum:
Heparin is a naturally occurring anticoagulant in the blood that enhances the action of the antithrombin III that inhibits the blood clot.  

Heparin is a powerful anticoagulant and is used in different pathologic states involving formation of blood clots, like postoperative state, deep vein thrombosis, pulmonary embolism and myocardial infarction. It is also used in surgeries involving heart bypass, and dialysis to avert the formation of blood clots. Moreover, it is employed as a preventive agent in high cardiovascular risk patients who have atrial fibrillation and as the therapy for patients with DIC and the antiphospholipid syndrome.

DRUG INTERACTION

heparin

&

  • Pembrolizumab / Berahyaluronidase
  • Bumetanide Intranasal
  • Gemcitabine intravesical
  • Rilzabrutinib
  • Zopapogene
  • Aceclidine
  • aluminium hydroxide
  • benzralizumab (Rx)
  • Rituximab
  • Trimetrexate Glucuronate
  • Mirdametinib
  • Suzetrigine
  • Potassium acid phosphate
  • Acellular Tissue Engineered Vessel
  • crinecerfont (pending approval from FDA)
  • Revumenib
  • pembrolizumab (Rx)
  • azathioprine (Rx)
  • Gemcitabine (Rx)
  • Seladelpar
  • Atezolizumab / Hyaluronidase-tqjs
  • Axatilimab-csfr
  • Afamitresgene Autoleucel
  • Lazertinib
  • Ocrelizumab / Hyaluronidase ocsq
  • Lebrikizumab
  • naloxone intranasal
  • clomiphene
  • patisiran
  • imetelstat
  • phenylephrine ophthalmic
  • myoinositol
  • vasicinone
  • soda lime
  • fisetin
  • Reynoutria Japonica
  • Coco Monoethanolamide
  • Betadex
  • lithopone
  • cyperus rotundus
  • papaya juice
  • 1-naphthaleneacetic acid
  • Nordazepam
  • Glechoma hederacea
  • Alternanthera sessilis
  • nicofetamide
  • napthol asol
  • cocamidopropyl betaine
  • musa x paradisiaca
  • dicyclomine/mefenamic acid
  • Sorghum
  • Manganese citrate
  • tovorafenib
  • mefenamic acid/paracetamol
  • eschscholzia californica
  • canna indica root
  • tranexamic acid/mefenamic acid
  • dexverapamil
  • sitogluside
  • secalciferol
  • cefatrizine
  • Sedum Acre
  • Flurogestone
  • Fluocortin
  • Bifendate
  • piprozolin
  • aminacrine undecylate
  • ethylenediamine mandelate
  • pelubiprofen
  • hesperetin
  • butethamine
  • epitiostanol
  • androstenediol
  • Nitroxoline
  • Iocarmic acid
  • Capobenic acid
  • dordaviprone (investigational drug)
  • Vitexin
  • Friluglanstat (investigational drug)
  • scorias spongiosa
  • Luseogliflozin
  • indoxacarb
  • prademagene zamikeracel
  • fidanacogene elaparvovec-dzkt
  • albifylline
  • idanpramine
  • araneus diadematus
  • Sulfamazone
  • Lycosa tarantula
  • malotilate
  • Ethacizine
  • Namilumab
  • Latrunculin B
  • stachyose
  • platinic oxide
  • iopronic acid
  • calcium chloride / potassium chloride/lactic acid/ sodium chloride/sodium hydroxide/sodium lactate solution
  • citric acid/ sodium bicarbonate/ sodium carbonate anhydrous
  • vadadustat
  • permethrin medical grade cis/trans isomers 25/75
  • lutetium, isotope of mass 177
  • human normal immunoglobulin
  • sacrosidase
  • apadamtase alfa, recombinant
  • acetyl hexapeptide-8 amide
  • pemivibart (Investigational)
  • govorestat
  • Zanidatamab
  • sotatеrcеpt
  • MV 140 vaccine
  • leuprorelin implant
  • cinchocaine hydrochloride/fluocortolone hexanoate/fluocortolone pivalate
  • Beautyberry
  • risedronate/calcium/vitamin D3
  • rhubarb extract/senna leaf/sulphur purified/wood charcoal
  • boric acid/kaolin/methyl salicylate/peppermint oil/thymol
  • docosahexaenoic acid/eicospentaenoic acid
  • aluminium hydroxide/magnesium hydroxide/simethicone
  • gentamicin/hydrocortisone
  • succinylcholine
  • sinefungin
  • letibotulinumtoxinA
  • coal tar/coconut oil/salicylic acid
  • camphor/camphor oil white/capsicum oleoresin /menthol/methyl salicylate
  • thioglycolic acid
  • acetic acid auricular
  • roluperidone
  • hydrocortisone/crotamiton topical
  • nystatin/chlorhexidine
  • aluminium chloride hexahydrate
  • ketoprofen topical
  • Chlormethine
  • podophyllotoxin
  • urea/lactic acid
  • autologous chondrocytes implant
  • afelimomab
  • gepotidacin
  • fludroxycortide
  • fentanyl transdermal
  • erythromycin/zinc acetate
  • dibotermin alfa powder
  • desferrioxamine mesilate
  • choline salicylate/magnesium salicylate
  • castor oil/peru balsam/trypsin
  • betamethasone/dexchlorpheniramine maleate
  • benzalkonium chloride solution/cetrimide
  • barzolvolimab
  • ascorbic acid / calcium laevulinate / nicotinamide / calcium pantothenate / calcium chloride / riboflavine / pyridoxine hydrochloride / thiamine hydrochloride
  • argipressin
  • arachis oil refined/chlorobutanol hemihydrate
  • arachis oil/eucalyptol/nutmeg oil/terpineol
  • ammonium chloride/diphenhydramine hydrochloride/levomenthol
  • amino acid mixture d / calcium chloride dihydrate / glucose monohydrate / glycine / magnesium chloride hexahydrate / olive oil / potassium chloride / sodium acetate trihydrate / sodium glycerophosphate pentahydrate / soya-bean oil
  • biotin/colecalciferol/copper (ii)sulfate dried/ cyanocobalamine/ dl-alpha tocopherol acetate/dibasic calcium phosphate anhydrous/folic acid/iron (ii)sulfate dried/ lecithin/ magnesium sulfate dried/ nicotinamide/ pyridoxine hydrochloride/ riboflavin
  • ampicillin sodium / cloxacillin sodium
  • undecylenic acid, undecylenate salts, zincundecate
  • omeprazole/sodium bicarbonate
  • efgartigimod alfa/hyaluronidase
  • xylometazoline/ipratropium
  • cefepime and enmetazobactam
  • isotonic sodium chloride
  • bee venom allergen injection
  • fentanyl intranasal
  • alglucosidase alfa
  • triprolidine/pseudoephedrine
  • pegademase bovine
  • castor oil and peru balsam
  • camphor/eucalyptus oil/menthol
  • oxyquinoline/sodium lauryl sulfate
  • somatorelin
  • menotrophin injection
  • menadiol
  • hylan g-f 20
  • cefepime and taniborbactum
  • water avens
  • camphor/menthol
  • acoramidis
  • elafibranor
  • arrowroot
  • miconazole nitrate/hydrocortisone
  • vildagliptin/metformin
  • dobesilic acid
  • aroxybutynin and atomoxetine
  • hygromycin
  • linvoseltamab
  • nemolizumab
  • aceprometazine
  • limaprost
  • oxazolam
  • trimegestone
  • teceleukin
  • beauty berry
  • dinotefuran
  • imiprothrin
  • transfluthrin
  • thymalfasin
  • technetium Tc 99m tilmanocept
  • glepaglutide
  • marstacimab
  • pixantrone
  • Andiroba
  • arabinoxylan
  • arenaria rubra
  • etripamil
  • jequirity
  • jiaogulan
  • dusquetide
  • rolipram
  • tradipitant
  • sinfungin
  • diclofenac/omeprazole
  • brinzolamide and timolol maleate
  • wormseed
  • wormwood
  • wood sorrel
  • carmellose sodium
  • ibandronic acid
  • cinnarizine and dimenhydrinate
  • ursodeoxycholic acid
  • rhubarb extract/salicylic acid
  • butamirate citrate
  • fumitory
  • taheebo
  • uva ursi
  • vervain
  • coleus
  • coltsfoot
  • crampbark
  • plantain
  • potassium nitrate and silver nitrate
  • gelsemium
  • gentian
  • glucomannan
  • walnut
  • meadowsweet
  • midomafetamine
  • pennyroyal
  • periwinkle
  • betony
  • bitter orange
  • bladderwrack
  • bloodroot
  • emu oil
  • garcinia
  • yellow dock
  • burdock
  • dehydroepiandrosterone
  • aucubin
  • jasmone
  • resacetophenone
  • ecamsule ditriethanolamine
  • feclobuzone
  • fenoprop triethanolamine
  • verdyl acetate
  • caffeic acid
  • cyclamen aldehyde
  • dicetyldimonium chloride
  • wogonin
  • impacarzine
  • laurylpyridinium chloride
  • stepronin
  • matrine
  • sakuranin
  • cannabichromene
  • sandalore
  • sabinene
  • oxypaeoniflora
  • ethylhexyl pelargonate
  • acrylonitrile
  • allyl alcohol
  • dipalmitoylethyl hydroxyethylmonium methosulfate
  • butidrine
  • clothiapine
  • propanediol dicaprylate
  • buchu
  • undecanol
  • enilconazole
  • xymenynic acid
  • angelica
  • nizubaglustat
  • resomelagon
  • ulecaciclib
  • apple cider vinegar
  • bacopa
  • barley grass
  • dandelion
  • deer velvet
  • dolomite
  • bugleweed
  • bupleurum
  • glyceryltrinitrate
  • pociredir
  • asnuciclib
  • actalycabtagene autoleucel
  • butantan–dengue vaccine
  • travoprost/timolol
  • furosemide/potassium chloride
  • amylamine
  • jaborandi
  • patritumab deruxtecan
  • jackfruit
  • sterculia
  • ascorbigen
  • ashitaba
  • androstenetrione
  • andrachne
  • cosibelimab
  • racecadotril
  • neomycin/chlorhexidine
  • octocog alfa
  • cetrimide
  • ispaghula husk
  • polyhexanide
  • octenidine
  • polygeline
  • heparinoid
  • jewelweed
  • boldo
  • anizatrectinib
  • alpinia
  • henbane
  • cynanchum vincetoxicum root and sulfur
  • boditrectinib
  • izumerogant
  • zavondemstat
  • abuta
  • fadogia agrestis
  • fly agaric mushroom
  • meptazinol
  • methoxyflurane
  • tramadol/dexketoprofen
  • betaine/polyhexanide
  • filgotinib
  • inosine acedoben dimepranol
  • alverine citrate
  • hyoscine butylbromide
  • senna+ ispaghula
  • cabbage palm
  • cajeput oil
  • calanus oil
  • calamint
  • canada balsam
  • carnosine
  • alverine citrate/simeticone
  • dihydroartemisinin/piperaquine
  • mebeverine/ispaghula
  • calcipotriol
  • tacalcitol
  • triethyl citrate/ethyl linoleate
  • sodium dilauramidoglutamide lysine
  • fazamorexant
  • avibactam tomilopil and ceftibuten
  • drostanolone
  • tigilanol tiglate
  • isorhynchophylline
  • rhynchophylline
  • crisugabalin
  • epigallocatechin gallate
  • clomocycline
  • corynoxeine
  • isocorynoxeine
  • Culmerciclib
  • Neladenoson
  • ambrein
  • hexylcaine
  • phensuximide
  • resencatinib (investigational)
  • rolusafine
  • pumecitinib
  • arhalofenic acid
  • berdazimer sodium
  • benzquinamide
  • clidinium
  • sulfametopyrazine
  • fulzerasib (Investigational Drug)
  • rovadicitinib (Investigational Drug)
  • Upleganan (Investigational Drug)
  • menthyl ethylamido oxalate
  • quaternium-90 montmorillonite
  • unecritinib (investigational drug)
  • etohexadiol
  • guaiol
  • proximadiol
  • verdinexor
  • sofnobrutinib
  • talbutal
  • ethoxzolamide
  • propiomazine
  • enprofylline
  • phenmetrazine
  • merigolix
  • pralurbactam
  • neracorvir
  • vonifimod
  • apaziquone hydroquinone
  • darizmetinib
  • zandelisib
  • xininurad
  • ritivixibat
  • amiselimod phosphate (investigational drug)
  • emzeltrectinib (investigational drug)
  • ficonalkib
  • cinalukast
  • ulobetasol
  • candoxatril
  • nitrofural
  • acetyldigitoxin
  • bentiromide
  • dextrothyroxine
  • chlorotrianisene
  • remikiren
  • pipobroman
  • vidarabine
  • immune globulin intravenous, human-stwk
  • spermine
  • serine
  • N-acetyl glucosamine
  • valine
  • adenine
  • asparagine
  • citrulline
  • adinazolam
  • interferon alfacon-1
  • interferon alfa-n1
  • felypressin
  • birch triterpenes
  • pyridoxal phosphate
  • technetium Tc-99m arcitumomab
  • beta-alanine
  • dihomo-gamma-linolenic acid
  • urea/hydrocortisone
  • R21/Matrix-M vaccine
  • povidone-iodine (ophthalmic)
  • pheniramine
  • hydrocortisone rectal
  • chloroxylenol/pramoxine/zinc acetate
  • chloroxylenol/pramoxine
  • dextrose/sucrose/vitamin C/zinc sulphate
  • furazolidone/metronidazole/dicyclomine
  • ergocalciferol (vitamin D2)
  • benoxaprofen (discontinued)
  • teicoplanin
  • carbomer
  • chromic chloride / iron (ii) chloride tetrahydrate / potassium iodide / manganese chloride / sodium fluoride / sodium selenite pentahydrate / sodium molybdate dihydrate / zinc chloride/ cupric chloride
  • bufylline
  • lidocaine/prilocaine
  • opium tincture, squill oxymel
  • dibrompropamidine
  • metronidazole/tetracycline/bismuth subsalicylate
  • agnus- castus
  • velaglucerase alfa
  • alendronic acid / colecalciferol
  • bimatoprost / timolol
  • efbemalenograstim alfa
  • dried ferrous sulfate/folic acid
  • dried ferrous sulfate / sodium ascorbate
  • nirogacestat
  • soya-bean oil, medium-chain triglycerides
  • demeclocycline hydrochloride and triamcinolone acetonide
  • fusidic acid / hydrocortisone acetate
  • macrogol
  • storax, benzoin
  • nomegestrol acetate/estradiol
  • flumetasone pivalate/ clioquinol
  • berdazimer topical (Pending FDA Approval)
  • buflomedil
  • butobarbital
  • andexanet alfa
  • methoxypolyethylene glycol-epoetin beta
  • viscum abietis
  • pramoxine vaginal
  • bupivacaine implant
  • cromolyn sodium, inhaled
  • pneumococcal vaccine 20-valent
  • bimatoprost ophthalmic implant
  • tick-borne encephalitis vaccine
  • chloroprocaine ophthalmic
  • travoprost intraocular implant (Pending FDA approval)
  • typhoid polysaccharide vaccine
  • sodium phosphate
  • human papillomavirus vaccine, nonavalent
  • peanut immunotherapy epicutaneous (FDA approval pending)
  • cromolyn sodium, intranasal
  • red blood cells(Blood component)
  • oral mucoadhesive
  • clindamycin vaginal
  • whole blood (Blood Component)
  • fibrinogen/thrombin
  • levothyroxine/liothyronine
  • ipratropium intranasal
  • metronidazole vaginal
  • cyamemazine
  • brinase
  • reviparin
  • ulinastatin
  • saruplase
  • acepromazine
  • emylcamate
  • methionine
  • amino acids and electrolytes in dextrose with calcium
  • slippery elm
  • camostat
  • hemoglobin crosfumaril
  • moperone
  • chlormidazole
  • brilaroxazine
  • palopegteriparatide
  • diazepam buccal
  • benegrastim (pending for FDA approval)
  • COVID-19 vaccine, adjuvanted-Novavax
  • vestronidase alfa-vjbk
  • tebipenem (Pending FDA Approval)
  • tislelizumab (Pending FDA Approval)
  • zolbetuximab (Pending FDA Approval)
  • zoliflodacin (pending FDA approval)
  • zibotentan and dapagliflozin
  • fluorine F18 DCFPyL
  • debamestrocel
  • givinostat
  • amubarvimab and romlusevimab(Pending FDA Approval)
  • sabizabulin(Pending FDA approval)
  • fexapotide(Phase 3 Clinical trial)
  • diatrizoic acid
  • drotaverine
  • diethyl phthalate
  • enclomiphene
  • epalrestat
  • ethamsylate
  • flupirtine
  • imidurea
  • sodium glycolate
  • feracrylum
  • ethacridine
  • furazolidone/metronidazole
  • ozagrel hydrochloride
  • leptazol
  • l-glutamic acid /vitamin B complex
  • etizolam
  • etizolam/propranolol
  • ethoheptazine citrate
  • etophylline and theophylline
  • etophylline
  • finger millet
  • drotaverine/mefenamic acid
  • dichloroxylenol
  • pneumococcal 7-valent vaccine
  • diclofenac and metaxalone
  • dipivefrin ophthalmic
  • enbucrilate
  • potassium citrate and citric acid
  • potassium gluconate
  • aclarubicin
  • alfuzosin/dutasteride
  • adrenochrome monosemicarbazone
  • selenium sulfide topical
  • sertaconazole
  • amorolfine cream
  • amsacrine
  • amylmetacresol
  • sulfonated phenolics in aqueous solution
  • technetium Tc-99m sulfur colloid
  • raltitrexed
  • romiplostim
  • acediasulfone
  • azulene
  • acebrophylline
  • clonazepam/escitalopram oxalate
  • allylestrenol
  • andrographolide
  • artemotil
  • technetium Tc-99m sestamibi
  • rubidium Rb-82
  • somapacitan
  • sodium sulfate, magnesium sulfate and potassium sulfate
  • almitrine
  • gramicidin
  • nikethamide
  • technetium Tc-99m sodium pertechnetate
  • betiatide
  • prilocaine/epinephrine
  • amlexanox
  • acetaminophen/salicylamide/phenyltoloxamine
  • neomycin topical
  • zilucoplan
  • antazoline and xylometazoline
  • toripalimab
  • iron isomaltoside
  • meningococcal A C Y and W polysaccharide tetanus toxoid conjugate vaccine
  • meningococcal A C Y and W-135 diphtheria conjugate vaccine
  • tetradecyl Sulfuric Acid
  • benzoyl peroxide, clindamycin phosphate, adapalene
  • ethylephedrine
  • actarit
  • pyrantel tartrate
  • tenofovir disoproxil fumarate or tenofovir DF
  • melitracen
  • amitriptylinoxide(Phase 4 Clinical Trials)
  • threonine
  • ditiocarb zinc
  • epicriptine
  • levallorphan
  • kinetin
  • laurocapram
  • pentagastrin
  • parthenolide
  • nicoboxil
  • protionamide
  • prulifloxacin
  • proscillaridin
  • tizanidine and rofecoxib
  • tolnaftate, gentamicin, chinoform and betamethasone valerate
  • pine bark extract
  • pipenzolate methylbromide
  • bephenium hydroxynaphthoate
  • niclosamide
  • pyrvinium
  • pipenzolate methylbromide/phenobarbitone
  • piracetam/ginkgo biloba/vinpocetine
  • benzyl benzoate/disulfiram
  • benzyl benzoate
  • loperamide/simethicone
  • piroctone olamine
  • sodium fusidate
  • piroxicam topical/capsaicin/menthol/methyl salicylate
  • sodium metabisulfite
  • sodium lauryl sulfate
  • taspoglutide
  • glyclopyramide
  • tolnaftate, gentamicin, iodochlorohydroxyquinoline, chlorocresol, betamethasone valerate
  • serratiopeptidase
  • sodium antimony gluconate
  • triamterene / benzthiazide
  • tribenoside / lidocaine
  • triclocarban
  • triprolidine/dextromethorphan  
  • vitamins/minerals/omega-3 Fatty acids
  • soyabean oil
  • sucralfate/oxethazaine
  • sucralfate/tinidazole/povidone iodine
  • sodium cromoglycate
  • aloe vera/liquid paraffin/white soft paraffin
  • aloe vera/jojoba oil/vitamin E
  • allantoin/triclosan/vitamin e/zinc oxide
  • alpha-Lipoic acid/minerals/multivitamins
  • alprazolam/paracetamol
  • alprazolam/melatonin
  • azithromycin/ambroxol
  • atorvastatin/clopidogrel/aspirin
  • aceclofenac, paracetamol and serratiopeptidase
  • alfacalcidol, vitamin B-complex, minerals and antioxidants
  • alpha- lipoic acid, vitamin b complex and vitamin c
  • alpha-galactosidase and simethicone
  • alpha-galactosidase, amylase, proteases, lipase and lactase
  • amikacin and cefepime
  • aminophylline, ephedrine and phenobarbitone
  • artesunate, sulphadoxine and pyrimethamine
  • finasteride/tamsulosin
  • flavoxate/ofloxacin
  • fenofibrate/metformin
  • lignocaine, hydrocortisone topical and allantoin
  • linoleic acid and sodium lactate
  • troxerutin
  • meclizine/nicotinic acid
  • mecobalamin/ginkgo Biloba
  • spirulina
  • loperamide and furazolidone
  • ketoconazole/cetrimide
  • ketoconazole/zinc pyrithione
  • lercanidipine/atenolol
  • levocetirizine/montelukast/ambroxol
  • levarterenol
  • levocetirizine/phenylpropanolamine 
  • indapamide/amlodipine
  • itopride/methyl polysiloxane
  • mebendazole/levamisole
  • eberconazole/mometasone
  • gliclazide/metformin/pioglitazone
  • fluconazole/tinidazole
  • haemocoagulase
  • halometasone
  • hesperidin
  • imipramine/chlordiazepoxide
  • idebenone / l-arginine / zinc sulphate/selenium/proanthocyanidin
  • mecobalamin and piracetam
  • mesterolone
  • mosapride and pantoprazole
  • atorvastatin, co enzyme q10, vitamin e, zinc, and selenium
  • azithromycin and benzalkonium chloride
  • beta carotene, vitamin c, vitamin e, minerals, lutein, eicosapentaenoic acid, docosahexenoic acid and vit b12
  • alpha-galactosidase
  • aloe vera gel/vitamin e/lactic acid
  • aloe vera gel/jojoba/vitamin e/glycerine
  • famotidine and domperidone
  • faropenem medoxomil
  • nedosiran
  • fluconazole/ornidazole/azithromycin
  • ebastine/montelukast
  • eberconazole
  • dienogest/estradiol valerate
  • ambroxol/salbutamol
  • benzoic acid/salicylic acid/ichthammol/ triamcinolone acetonide
  • desloratadine/ambroxol
  • dexibuprofen/paracetamol
  • atorvastatin/ramipril
  • diastase
  • diastase and simethicone
  • diazepam and propranolol
  • dexrabeprazole / domperidone
  • dexrabeprazole
  • dexketoprofen /paracetamol
  • beta carotene/vitamin C/minerals
  • aloe vera gel/urea
  • aloe vera gel/glycerine
  • alpha-lipoic acid/benfotiamine/chromium/folic acid/mecobalamin / vit b6
  • alprazolam/propranolol
  • alprazolam /sertraline
  • ibuprofen/dextropropoxyphene
  • ambroxol/cetirizine/phenylephrine/ guaiphenesin/menthol
  • dextropropoxyphene/dexchlorpheniramine maleate/bromhexine
  • promegestone
  • batroxobin
  • bencyclane
  • benfluorex
  • acetylpheneturide
  • abarelix
  • abetimus
  • naftidrofuryl
  • nalorphine
  • oxiracetam
  • letosteine
  • lafutidine
  • leuprorelin
  • levodropropizine
  • glutaral
  • losartan/ramipril
  • gallopamil
  • lanatoside c
  • lauromacrogol
  • gestodene
  • aceclofenac/methyl salicylate/menthol/linseed oil/capsaicin
  • aceclofenac/paracetamol/tizanidine
  • alginic acid/magaldrate/simethicone
  • aceclofenac/paracetamol
  • aceclofenac/rabeprazole
  • alginic acid
  • pantoprazole and domperidone
  • urokinase
  • rimiterol
  • olanzapine/fluoxetine
  • normethadone/hydroxyephedrine
  • myrtol
  • moxonidine
  • propylhexedrine
  • sodium hypochlorite solution
  • sodium chloride/sodium citrate
  • Hepatitis B Vaccine (Recombinant [Adjuvanted])
  • Hepatitis B Vaccine (Recombinant)
  • aceclofenac and serratiopeptidase
  • levosulpiride
  • niaprazine
  • tromantadine
  • trimetazidine
  • vinburnine
  • mizoribine
  • molgramostim
  • mosapride
  • eugenol
  • tolperisone
  • etamsylate
  • etynodiol
  • mizolastine
  • metenolone
  • reproterol
  • rebamipide
  • mephenoxalone
  • metandienone
  • furosemide/spironolactone
  • hydroxycarbamide
  • tenonitrozole
  • fenoverine
  • fenquizone
  • tiapride
  • tibolone
  • furazolidone
  • furosemide & amiloride
  • fosfestrol
  • fluclorolone
  • flubendazole
  • tertatolol
  • tetracosactide
  • tetryzoline
  • tolciclate
  • trapidil
  • troxipide
  • temoporfin
  • telbivudine
  • teprenone
  • hexamidine
  • mebhydrolin
  • mepartricin
  • fencamfamin
  • medazepam
  • theodrenaline
  • thiamazole
  • thiocolchicoside
  • psilocybin
  • veralipride
  • pyritinol
  • opipramol
  • oprelvekin
  • betamethasone + gentamicin
  • betamethasone + neomycin
  • betamethasone + salicylic acid
  • oxedrine
  • bopindolol
  • orgotein (investigational)
  • oxaceprol
  • ormeloxifene
  • bevantolol
  • bifemelane
  • clebopride
  • demoxytocin
  • cicletanine
  • cefsulodin
  • chlortalidon
  • sisomicin
  • somatrem
  • carbazochrome
  • caroverine
  • cathine
  • ipriflavone
  • isepamicin
  • silymarin
  • simethicone
  • sermorelin
  • diloxanide
  • dimethindene
  • diosmin/hesperidin
  • calamine
  • canrenone
  • captodiame
  • imidapril
  • cefetamet
  • cefodizime
  • cefoperazone + sulbactam
  • ivermectin + albendazole
  • serrapeptase
  • bromisoval
  • beraprost
  • pridinol
  • proglumide
  • bamipine
  • barnidipine
  • bamifylline
  • benzbromarone
  • betamethasone/fusidic acid
  • para-chlorophenol
  • pantethine
  • nomifensine
  • pemoline
  • parnaparin
  • pentolinium
  • nialamide
  • novobiocin
  • nicergoline
  • octocrylene
  • octisalate
  • oftasceine
  • oxolamine
  • oxyphencyclimine
  • penfluridol
  • pentoxyverine
  • phenoxymethylpenicillin
  • picloxydine
  • pilsicainide hydrochloride
  • piperazine
  • pirarubicin
  • policresulen
  • prifinium bromide
  • prethcamide
  • pristinamycin
  • pirenzepine
  • piribedil
  • pimethixene
  • pargyline
  • phosphatidyl choline
  • phthalylsulfathiazole
  • phytomenadione
  • pranlukast
  • pinazepam
  • oxyphenonium
  • noxytiolin
  • periciazine
  • pethidine
  • phenindamine
  • histidine
  • isoleucine
  • proline
  • lauric acid
  • lymecycline
  • hypromellose
  • abiraterone acetate and niraparib
  • ichthammol
  • levamisole
  • naftazone
  • nefopam
  • oxprenolol
  • oxybuprocaine
  • elranatamab-bcmm
  • lapyrium
  • isoaminile
  • iotrolan
  • mazindol
  • masoprocol
  • lypressin
  • meradimate
  • molsidomine
  • monobenzone
  • mequinol/gluconolactone/ lactobionic acid/ arbutin
  • medifoxamine
  • mebutamate
  • metergoline
  • methantheline
  • methdilazine
  • metocurine
  • micronomicin
  • metaraminol
  • mephenesin
  • menadione
  • medrysone
  • metixene
  • levobetaxolol
  • guaiacol glycerol ether
  • eucalyptol
  • sodium tetradecyl sulfate
  • sugammadex
  • carbetocin
  • certoparin
  • chlorcyclizine/pseudoephedrine
  • cephapirin
  • indecainide
  • iobitridol
  • iomeprol
  • chlorphenesin
  • msud analog
  • msud maxamum
  • iceland moss
  • glutethimide
  • hexachlorophene
  • haloprogin
  • deferoxamine
  • ethchlorvynol
  • dexpanthenol topical
  • etilefrine
  • deslanoside
  • carbocromen
  • diazolidinylurea
  • dibenzepin
  • etofamide
  • guanoxan
  • halazepam
  • guanadrel sulfate
  • dapiprazole
  • soapwort
  • debrisoquine
  • l-tryptophan
  • chlormerodrin
  • chlorquinaldol
  • cetrimonium
  • carbocisteine
  • chlorcyclizine/codeine
  • technetium Tc-99m tetrofosmin
  • technetium Tc-99m disofenin
  • technetium Tc-99m gluceptate
  • technetium Tc-99m labeled red blood cells
  • amylmetacresol/dextromethorphan hydrobromide
  • anileridine phosphate
  • pyrethrins
  • pyrantel pamoate
  • quinagolide
  • spiramycin
  • standard hyperkalemic cardioplegia solution
  • technetium tc-99m mertiatide
  • technetium tc-99m medronate
  • bemotrizinol / bisoctrizole
  • benfotiamine
  • bemotrizinol + titanium dioxide + zinc oxide
  • technetium Tc-99m oxidronate
  • technetium Tc-99m pentetate
  • technetium Tc-99m pyrophosphate
  • benziodarone
  • octinoxate/bisoctrizole
  • bicisate dihydrochloride
  • technetium Tc-99m bicisate
  • norelgestromin/ethinyl estradiol
  • norgestimate/ethinyl estradiol
  • ximelagatran (investigational)
  • xamoterol
  • trioxsalen
  • poly-urea urethane
  • rilmenidine
  • pemirolast
  • oxitriptan
  • beclomethasone, intranasal
  • thimerosal
  • camphor gel
  • camphor
  • mumps virus vaccine, live
  • rubella virus vaccine, live
  • aluminum chloride (dental)
  • alum irrigation
  • framycetin, phenylephrine, and gramicidin
  • ombitasvir, paritaprevir, ritonavir, and dasabuvir
  • olipudase alfa
  • etonogestrel/ethinyl estradiol
  • mycophenolate
  • fluoroestradiol F 18
  • donor organ cardioplegia solution
  • fluciclovine F 18
  • fusidic acid (ophthalmic)
  • fusidic acid and hydrocortisone
  • framycetin, dexamethasone, and gramicidin
  • fludeoxyglucose F-18
  • fluorouracil/salicylic acid
  • indium In-111 oxyquinoline
  • indium In-111 pentetreotide
  • indium In-111 capromab pendetide
  • lusutrombopag
  • mitomycin (ophthalmic)
  • mifepristone and misoprostol
  • minoxidil (systemic)
  • methyl aminolevulinate (topical)
  • methyl folate, methylcobalamin, and acetylcysteine
  • ciclesonide/formoterol/tiotropium
  • nedocromil (Oral Inhalation)
  • batefenterol (Investigational)
  • neostigmine and glycopyrrolate
  • nepafenac ophthalmic
  • netupitant/palonosetron
  • meperidine and promethazine
  • mepivacaine and levonordefrin
  • maltodextrin
  • medical cannabis
  • medium chain triglycerides
  • mometasone/glycopyrrolate (glycopyrronium)/ indacaterol
  • moxifloxacin ophthalmic
  • neomycin/fluocinolone
  • nadroparin
  • iodine I-125 iothalamate
  • amikacin liposome (oral inhalation)
  • bupivacaine liposome
  • natamycin
  • lopinavir and ritonavir
  • lysine
  • macitentan and tadalafil
  • mitomycin pyelocalyceal
  • moclobemide
  • mometasone and indacaterol
  • efinaconazole
  • blue-green algae
  • indocyanine green
  • follitropin beta
  • lumasiran
  • glycerin/lidocaine
  • edrophonium/atropine
  • indigo carmine
  • lutropin alfa
  • instant glucose/intravenous dextrose
  • iobenguane I-123
  • ixekizumab
  • isosulfan blue dye
  • levofloxacin ophthalmic
  • levonorgestrel oral/ferrous bisglycinate/ ethinylestradiol
  • ethinyl estradiol/levonorgestrel transdermal
  • hydroquinone
  • hydroxypropyl methylcellulose
  • icodextrin
  • lipid emulsion (soybean, medium-chain triglyceride, olive, and fish oils; [SMOF])
  • iodinated I 125 albumin
  • iodinated I 131 albumin
  • lipid emulsion (plant oil-based)
  • levonorgestrel intrauterine
  • levonorgestrel/ethinyl estradiol
  • lactic acid and sodium-PCA
  • lactated Ringer solution
  • ketotifen (systemic)
  • lanolin
  • leuprolide and norethindrone
  • levodopa and benserazide
  • gonadorelin acetate
  • hemodialysis solutions
  • nirsevimab
  • gentian violet
  • gallium ga-68 dotatate
  • fusidic acid and betamethasone
  • gallium citrate Ga-67
  • gadopentetate dimeglumine
  • gadofosveset
  • follitropin delta
  • follitropin alfa and lutropin alfa
  • follitropin alfa
  • rocatinlimab
  • grass pollens allergen extract
  • flotufolastat F18
  • fluorescein ophthalmic
  • barium
  • balanced salt solution
  • air polymer type A intrauterine device
  • clodronate
  • bentoquatam
  • clobetasone
  • alfacalcidol
  • citric acid/glucono-delta-lactone/magnesium carbonate
  • benzoin
  • desirudin
  • immune globulin IV (IGIV)
  • dequalinium
  • pseudoephedrine/desloratadine
  • clofedanol
  • cyproterone and ethinyl estradiol
  • dextranomer and hyaluronic acid or derivatives
  • diatrizoate meglumine and diatrizoate sodium
  • glucosamine sulfate, chondroitin sulfate and Msm
  • squill
  • gotu kola
  • blessed thistle
  • bitter melon
  • apraclonidine
  • chlophedianol/dexbrompheniramine/pseudoephedrine
  • wild jujube
  • chitosan
  • cilazapril/hydrochlorothiazide
  • dexbrompheniramine and phenylephrine
  • diethylene triamine penta-acetic acid
  • dexchlorpheniramine and pseudoephedrine
  • lily of the valley
  • diflucortolone
  • corydalis
  • lemon balm
  • MSM
  • calcium polystyrene sulfonate
  • caprylidene
  • peppermint oil
  • efavirenz/lamivudine/tenofovir DF
  • emtricitabine/tenofovir DF /efavirenz
  • dutasteride/tamsulosin
  • milk thistle
  • centaury
  • horseweed
  • lycopus
  • agrimony
  • alfalfa
  • kava
  • cetrorelix
  • cetylpyridinium
  • chlophedianol and dexbrompheniramine
  • betahistine
  • choline C-11
  • boric acid vaginal suppository
  • aluminum acetate
  • aluminum chloride hexahydrate
  • 14-C urea breath test
  • absorbable collagen
  • valoctocogene roxaparvovec-rvox
  • amlodipine and celecoxib
  • aspirin and omeprazole
  • azilsartan and chlorthalidone
  • landiolol (Pending FDA approval)
  • isosorbide dinitrate/hydralazine
  • losartan/hydrochorothiazide
  • udenafil
  • dextromethorphan/quinidine
  • onasemnogene abeparvovec
  • orphenadrine/aspirin/caffeine
  • Trace elements
  • sodium phenylbutyrate/ taurursodiol
  • fish oil triglycerides
  • infant formula
  • glutamine
  • chloroquine phosphate
  • afatinib
  • quinidine gluconate
  • methylergonovine
  • prothrombin complex concentrate, human
  • BCG intravesical live
  • capivasertib
  • cedazuridine
  • carbonyl iron
  • iron dextran complex
  • lovotibeglogene autotemcel (FDA Approval Pending)
  • sodium benzoate/sodium phenylacetate
  • mineral oil otic
  • zolmitriptan transdermal
  • midazolam intranasal
  • fosinopril/hydrochlorothiazide
  • caplacizumab
  • arginine
  • sodium phenylbutyrate
  • meloxicam/rizatriptan
  • manganese
  • acetaminophen/pamabrom/pyridoxine
  • varicella zoster immune globulin, human
  • amitriptyline/perphenazine
  • narsoplimab (Pending FDA Approval)
  • amlodipine/perindopril
  • imiglucerase
  • canagliflozin/metformin
  • tafamidis meglumine
  • somatrogon-ghla
  • glimepiride/rosiglitazone
  • becaplermin
  • lithium
  • loxapine inhaled
  • nicotine transdermal
  • tixagevimab and cilgavimab (Investigational)
  • muromonab CD3
  • ansuvimab
  • coal tar bath products
  • fibrin sealant
  • arimoclomol (FDA Approval Pending)
  • varenicline intranasal
  • aducanumab
  • oxycodone/naloxone
  • ritlecitinib
  • sodium polystyrene sulfonate
  • calcipotriene/betamethasone
  • calcium hydroxylapatite
  • cantharidin topical
  • doxepin cream
  • clocortolone
  • formaldehyde topical
  • sodium sulfide topical
  • collagenase
  • selegiline transdermal
  • foscarbidopa/foslevodopa (FDA approval pending)
  • saxagliptin/metformin
  • linagliptin/metformin
  • linzagolix (FDA approval pending)
  • efgartigimod/hyaluronidase SC
  • Elamipretide
  • rozanolixizumab
  • diazoxide
  • glimepiride/pioglitazone
  • cipaglucosidase alfa
  • dihydroergotamine intranasal
  • delandistrogene moxeparvovec
  • beremagene geperpavec
  • hyaluronic acid and derivatives
  • hyaluronic acid, non-animal stabilized
  • eplontersen (FDA Approval Pending)
  • nitric oxide gas
  • sodium phenylbutyrate and taurursodiol
  • treprostinil SC
  • viltolarsen
  • albuterol/ipratropium
  • budesonide inhaled
  • budesonide rectal
  • palovarotene
  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  • amino acids mixture
  • aminobenzoate potassium
  • elivaldogene autotemcel
  • naproxen and sumatriptan
  • sumatriptan intranasal
  • alglucerase
  • metformin/rosiglitazone
  • ertugliflozin/metformin
  • elosulfase alfa
  • calcium carbonate/magnesium hydroxide
  • starch suppository
  • abicipar pegol (FDA Approval Pending)
  • riboflavin 5′-phosphate ophthalmic
  • povidone ophthalmic
  • glycerin oropharyngeal
  • dimethicone topical
  • menthol topical, dimethicone topical
  • pramoxine topical, menthol topical and dimethicone topical
  • phosphorated carbohydrate
  • brilliant blue G ophthalmic
  • brolucizumab intravitreal
  • purified water, ophthalmic
  • hydroxyethyl cellulose ophthalmic
  • ranibizumab intravitreal implant
  • sodium chloride hypertonic, ophthalmic 
  • cetirizine ophthalmic
  • phentolamine ophthalmic
  • ganciclovir ophthalmic
  • triamcinolone intravitreal
  • ocriplasmin intravitreal
  • atoltivimab/maftivimab/odesivimab
  • pegcetacoplan intravitreal
  • triamcinolone acetonide extended-release injectable suspension
  • tobramycin/loteprednol ophthalmic
  • 2-octyl cyanoacrylate
  • vitamins A & D topical
  • diphenhydramine/allantoin topical
  • pyrethrins/piperonyl butoxide
  • lodoxamide ophthalmic
  • obeticholic acid
  • fluocinolone intravitreal implant
  • sincalide
  • linaclotide
  • nedocromil ophthalmic
  • cysteamine ophthalmic
  • avacincaptad pegol intravitreal
  • azelastine ophthalmic
  • bacitracin ophthalmic
  • propylene glycol ophthalmic
  • rimexolone ophthalmic
  • metoclopramide intranasal
  • mirikizumab
  • netarsudil ophthalmic
  • cenegermin
  • dexamethasone ophthalmic insert
  • prednisolone ophthalmic
  • phenylephrine and cocoa butter rectal
  • phenylephrine and witch hazel topical
  • phenylephrine, pramoxine, glycerin and petrolatum rectal
  • bisacodyl rectal
  • aluminum hydroxide/magnesium carbonate
  • aluminum hydroxide/magnesium hydroxide
  • hyoscyamine spray
  • methenamine/methylene blue/ hyoscyamine/ sodium phosphate monobasic/ phenyl salicylate
  • phenylephrine
  • chlorophyll
  • castor oil
  • cholic acid
  • phenol oropharyngeal
  • articaine/epinephrine
  • antithymocyte globulin equine
  • aluminum hydroxide/magnesium trisilicate
  • methenamine/hyoscyamine
  • hydrocortisone topical/pramoxine topical 
  • sodium fluoride topical
  • mesna
  • C1 esterase inhibitor recombinant
  • menthol and pectin
  • menthol oropharyngeal
  • pectin oropharyngeal
  • gepirone
  • Goldenseal
  • polyethylene glycol and electrolytes
  • polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid
  • brompheniramine/pseudoephedrine/dextromethorphan
  • brompheniramine phenylephrine
  • acetaminophen/doxylamine/phenylephrine
  • doxylamine/acetaminophen/pseudoephedrine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan/phenylephrine
  • eslicarbazepine
  • fluticasone and salmeterol
  • codeine, acetaminophen, butalbital and caffeine
  • codeine, chlorpheniramine and phenylephrine
  • iodine
  • povidone iodine
  • butalbital/aspirin/caffeine/codeine
  • polyethylene glycol 400/propylene glycol ophthalmic 
  • pegvaliase
  • amivantamab
  • iopamidol
  • codeine and pseudoephedrine
  • emtricitabine, rilpivirine, tenofovir DF
  • penicillin G aqueous
  • miconazole topical
  • miconazole vaginal
  • ciprofloxacin inhaled (Pending FDA approval)
  • ceftazidime/avibactam
  • ceftolozane/​tazobactam
  • aztreonam inhalation
  • amphotericin B cholesteryl sulfate
  • miconazole oral
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF
  • isavuconazonium sulfate
  • dapivirine intravaginal (FDA Approval Pending)
  • lamivudine/raltegravir
  • codeine/triprolidine/pseudoephedrine
  • cadexomer iodine
  • brompheniramine/pseudoephedrine
  • codeine/acetaminophen
  • codeine/guaifenesin
  • beclomethasone inhaled
  • epoetin beta/methoxy polyethylene glycol
  • voreloxin(Orphan Drug)
  • rociletinib
  • pitcher plant
  • phosphatidylserine
  • telotristat ethyl
  • copper CU 64 dotatate
  • urea topical
  • exenatide subdermal implant
  • asenapine transdermal
  • ethiodized oil
  • urea oral
  • miglustat
  • acalisib(Investigational)
  • acetophenazine
  • guggul
  • aceneuramic acid
  • mestranol/norethindrone
  • reishi
  • lactitol
  • vonoprazan fumarate
  • motherwort
  • silver nitrate
  • salicylic acid/sulfur shampoo
  • salicylic acid topical
  • ketorolac ophthalmic
  • ketoconazole topical
  • Japanese encephalitis virus vaccine
  • dibucaine topical ointment
  • ketorolac intranasal
  • ketorolac/phenylephrine ophthalmic
  • rotavirus oral vaccine, live
  • guarana
  • hops
  • krill oil
  • salicylic acid/coal tar shampoo
  • sufentanil SL
  • pancrelipase
  • passion flower
  • pepdite one plus
  • nivolumab and relatlimab
  • relatlimab (Pending FDA Approval)
  • benzalkonium chloride/benzocaine
  • ketotifen, drug-eluting contact lens
  • calcitriol topical
  • oxymetazoline topical
  • alclometasone topical
  • capsaicin topical
  • diclofenac/misoprostol
  • diclofenac ophthalmic
  • diclofenac topical
  • pramoxine/calamine topical
  • veverimer
  • tolazoline
  • olopatadine ophthalmic
  • lutetium lu 177-dota-tate
  • lutetium lu 177 vipivotide tetraxetan
  • strontium 89 chloride
  • interferon alfa n3
  • lutetium Lu 177- Diethylenetriamine Pentaacetic acid-omburtamab (FDA Approval Pending)
  • samarium sm 153 lexidronam
  • cytomegalovirus immune globulin (CMV IG)
  • antithymocyte globulin rabbit
  • inolimomab (Pending FDA Approval)
  • olopatadine intranasal
  • olopatadine intranasal/​mometasone, intranasal
  • benzocaine/butamben/tetracaine topical
  • antipyrine/benzocaine/phenylephrine
  • dyclonine/menthol
  • surufatinib
  • fruquintinib
  • dostarlimab
  • hepatitis B immune globulin (HBIG)
  • remestemcel-L
  • benzocaine/menthol oropharyngeal
  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • human rabies immune globulin (HRIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • Methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-hydroxytryptophan (5-htp)
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine, live
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
heparin + 

Severity : Monitor Closely
The anticoagulant effects of ancord may be enhanced when administered concomitantly with other anticoagulants

aspirin

may have an increased anticoagulant effect when combined with Heparin

defibrotide sodium

may have an increased anticoagulant effect when combined with Heparin

tirofiban

may have an increased anticoagulant effect when combined with Heparin

vorapaxar

may have an increased anticoagulant effect when combined with Heparin

acetylsalicylic acid

may have an increased anticoagulant effect when combined with Heparin

tanshinone I

may have an increased anticoagulant effect when combined with heparin

rosmarinic acid

may have an increased anticoagulant effect when combined with heparin

caryophyllene

may have an increased anticoagulant effect when combined with heparin

ursolic acid

may have an increased anticoagulant effect when combined with heparin

cepharanthine

may have an increased anticoagulant effect when combined with heparin

clopidogrel

may have an increased anticoagulant effect when combined with heparin

ticagrelor

may have an increased anticoagulant effect when combined with heparin

aceclofenac/rabeprazole

may have an increased anticoagulant effect when combined with heparin

tanshinone I

may have an increased anticoagulant effect when combined with heparin

rosmarinic acid

may have an increased anticoagulant effect when combined with heparin

caryophyllene

may have an increased anticoagulant effect when combined with heparin

ursolic acid

may have an increased anticoagulant effect when combined with heparin

aspirin

may have an increased anticoagulant effect when combined with heparin

defibrotide sodium

may have an increased anticoagulant effect when combined with heparin

tirofiban

may have an increased anticoagulant effect when combined with heparin

vorapaxar

may have an increased anticoagulant effect when combined with heparin

acetylsalicylic acid

may have an increased anticoagulant effect when combined with heparin

diacerein

heparin: it may enhance the toxic effect of Anti-Inflammatory Agents

diphenhydramine/ibuprofen

heparin: it may enhance the toxic effect of Anti-Inflammatory Agents

aspirin, chlorpheniramine, and phenylephrine

heparin: it may enhance the toxic effect of Anti-Inflammatory Agents

saccharomyces boulardii

heparin: it may enhance the toxic effect of Anti-Inflammatory Agents

diroximel fumarate

heparin: it may enhance the toxic effect of Anti-Inflammatory Agents

anagrelide

may have an increased anticoagulant effect when combined with heparin

cilostazol

may have an increased anticoagulant effect when combined with heparin

prasugrel 

may increase the anti-coagulant effect of anti-platelet agents

aspirin/dipyridamole 

may increase the anti-coagulant effect of antiplatelet agents

mefenamic acid 

may increase the anti-coagulant effect of nonsteroidal anti-inflammatory agents

alfalfa 

may increase the anticoagulation effect when combined

desirudin 

desirubin: they may increase the anticoagulant effect of anticoagulants

anagrelide

may have an increased anticoagulant effect when combined with heparin

cilostazol

may have an increased anticoagulant effect when combined with heparin

aceclofenac/rabeprazole

may have an increased anticoagulant effect when combined with heparin

tanshinone I

may have an increased anticoagulant effect when combined with heparin

rosmarinic acid

may have an increased anticoagulant effect when combined with heparin

caryophyllene

may have an increased anticoagulant effect when combined with heparin

ursolic acid

may have an increased anticoagulant effect when combined with heparin

taheebo 

due to anticoagulant properties of taheebo, other anticoagulant use is contraindicated

bladderwrack 

use caution when bladderwrack is used in combination with anticoagulant medication due to antiplatelet action

bloodroot 

bloodroot along with anticoagulant medications will result in bleeding and bruising

indomethacin 

when combined, may increase anticoagulation

aceclofenac/rabeprazole

may have an increased anticoagulant effect when combined with heparin

oritavancin 

may decrease the therapeutic effect when combined with heparin

piperacillin

piperacillin will increase the effectiveness of heparin by anticoagulation

cefotetan

when both drugs are combined, there may be an increased effect of heparin by anticoagulation  

ceftriaxone

when both drugs are combined, there may be an increased effect of heparin by anticoagulation  

azithromycin

azithromycin decreases the metabolism of heparin and increases its effect

edoxaban 

may enhance the toxicity of the other through anti coagulation

hemin 

may enhance the effect of anticoagulants

edoxaban 

edoxaban increases the effect of anticoagulants

mifepristone 

it increases the toxicity of anticoagulants

omacetaxine 

anticoagulants increase the toxicity of omacetaxine

vorapaxar 

vorapaxar increases the toxicity of anticoagulants

apixaban 

may have an increased anticoagulant effect when combined with anticoagulants

corticorelin 

may have an increasingly adverse effect when combined with corticorelin

telavancin 

may decrease the therapeutic effect when combined with heparin

dabigatran 

may have an increased anticoagulant effect when combined with anticoagulants

pirfenidone

may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex

urokinase 

urokinase: they may increase the anticoagulant effect of anticoagulants

butabarbital 

the activity of heparin is reduced by butabarbital by enhancing metabolism

defibrotide sodium

thrombolytic Agents may enhance the anticoagulant effect of anticoagulants

azilsartan medoxomil

it increases the effect of hyperkalemia of angiotensin II receptor blockers

candesartan cilexetil

it increases the effect of hyperkalemia of angiotensin II receptor blockers

eprosartan

it increases the effect of hyperkalemia of angiotensin II receptor blockers

irbesartan

it increases the effect of hyperkalemia of angiotensin II receptor blockers

losartan

it increases the effect of hyperkalemia of angiotensin II receptor blockers

dicumarol

may enhance the adverse/toxic effect of anticoagulants

heparin

may enhance the adverse/toxic effect of anticoagulants

dalteparin

may enhance the adverse/toxic effect of anticoagulants

dicoumarol

may enhance the adverse/toxic effect of anticoagulants

idarucizumab

may enhance the adverse/toxic effect of anticoagulants

aspirin

other antiplatelet agents increase the effect of anticoagulating agents

defibrotide sodium

other antiplatelet agents increase the effect of anticoagulating agents

cilostazol

other antiplatelet agents increase the effect of anticoagulating agents

clopidogrel

other antiplatelet agents increase the effect of anticoagulating agents

ticagrelor

other antiplatelet agents increase the effect of anticoagulating agents

tirofiban

may have an increased anticoagulant effect when combined with anticoagulants

vorapaxar

may have an increased anticoagulant effect when combined with anticoagulants

acetylsalicylic acid

may have an increased anticoagulant effect when combined with anticoagulants

aliskiren 

may have an increased hyperkalemic effect when combined with aliskiren

telmisartan

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

valsartan

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

azilsartan medoxomil

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

candesartan cilexetil

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

eprosartan

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

spirapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

trandolapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

zofenopril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

benazepril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

captopril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

eplerenone 

may have an increased hyperkalemic effect when combined with eplerenone

levothyroxine 

may diminish the serum concentration when combined with levothyroxine

palifermin 

may enhance the serum concentration when combined with palifermin

pentoxifylline 

may have an increased anticoagulant effect when combined with heparin

spironolactone and hydrochlorothiazide

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

amiloride/hydrochlorothiazide

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

amiloride

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

canrenoic acid

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

eplerenone

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

mipomersen 

It may enhance the toxicity when combined with mipomersen

omega 3 carboxylic acids 

It may enhance the risk of bleeding by affecting coagulation when combined with omega-3 carboxylic acids

tanshinone I

nonsteroidal anti-Inflammatory agents may strengthen the anticoagulant effects of anticoagulants

rosmarinic acid

nonsteroidal anti-Inflammatory agents may strengthen the anticoagulant effects of anticoagulants

caryophyllene

nonsteroidal anti-Inflammatory agents may strengthen the anticoagulant effects of anticoagulants

ursolic acid

nonsteroidal anti-Inflammatory agents may strengthen the anticoagulant effects of anticoagulants

cepharanthine

nonsteroidal anti-Inflammatory agents may strengthen the anticoagulant effects of anticoagulants

anagrelide

antiplatelet agents increase the effect of anticoagulants

azilsartan medoxomil

heparins: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers

candesartan cilexetil

heparins: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers

eprosartan

heparins: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers

irbesartan

heparins: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers

losartan

heparins: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers

amprenavir

It may enhance the serum concentration when combined with CYP3A4 Substrates

fostemsavir

It may enhance the serum concentration when combined with CYP3A4 Substrates

indinavir

It may enhance the serum concentration when combined with CYP3A4 Substrates

acenocoumarol

may have an increased anticoagulant effect when combined with vitamin k antagonists

fluindione

may have an increased anticoagulant effect when combined with vitamin k antagonists

phenindione

may have an increased anticoagulant effect when combined with vitamin k antagonists

phylloquinone

may have an increased anticoagulant effect when combined with vitamin k antagonists

warfarin

may have an increased anticoagulant effect when combined with vitamin k antagonists

iloperidone

It may diminish the metabolism when combined with Heparins

iloprost

It may diminish the metabolism when combined with Heparins

selexipag

It may diminish the metabolism when combined with Heparins

betamethasone (systemic)

It may enhance the risk of adverse effects when combined with Anticoagulants

budesonide (oral inhalation)

It may enhance the risk of adverse effects when combined with Anticoagulants

budesonide intranasal

It may enhance the risk of adverse effects when combined with Anticoagulants

budesonide (Topical)

It may enhance the risk of adverse effects when combined with Anticoagulants

beclomethasone (nasal)

It may enhance the risk of adverse effects when combined with Anticoagulants

spironolactone and hydrochlorothiazide

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

amiloride/hydrochlorothiazide

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

eplerenone

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

spironolactone

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

triamterene

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

amiloride

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

canrenoic acid

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

when andexanet alfa is used with heparin, its therapeutic efficacy may be reduced

olmesartan

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

telmisartan

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

perindopril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

quinapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

ramipril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

rescinnamine

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

spirapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

pinacidil

may have an increased hyperkalemic effect when combined with potassium salts

soyabean oil 

heparin: it may decrease the therapeutic efficacy of soyabean oil

coleus 

both forskolin and heparin enhance anticoagulation

azathioprine

reduce therapeutic effects of heparin

gemcitabine

gemcitabine, by the unspecific reactions, increases the effect of heparin

fluorouracil

the effect of heparin is increased by fluorouracil with the help of an unspecific interaction mechanism

potassium iodide

it increases the effect of hyperkalemia in potassium salts

vitamin e

it may increase the action of anticoagulant effect

fluvoxamine

it may increase the effect of anticoagulants

aspirin

it may enhance the anticoagulant effect of anticoagulants

defibrotide sodium

it may enhance the anticoagulant effect of anticoagulants

acetylsalicylic acid

it may enhance the anticoagulant effect of anticoagulants

anagrelide

it may enhance the anticoagulant effect of anticoagulants

cilostazol

it may enhance the anticoagulant effect of anticoagulants

escitalopram

antiplatelet agents increase the effect of anticoagulants

fluoxetine

antiplatelet agents increase the effect of anticoagulants

choline magnesium trisalicylate

salicylates may enhance the anticoagulant effect of anticoagulants

iloperidone

may enhance the adverse/toxic effect of anticoagulants

iloprost

may enhance the adverse/toxic effect of anticoagulants

selexipag

may enhance the adverse/toxic effect of anticoagulants

aspirin

may increase the anticoagulant effect of anticoagulants

defibrotide sodium

may increase the anticoagulant effect of anticoagulants

vorapaxar

may increase the anticoagulant effect of anticoagulants

acetylsalicylic acid

may increase the anticoagulant effect of anticoagulants

anagrelide

may increase the anticoagulant effect of anticoagulants

iloprost 

may increase the toxic effect of prostacyclin analogs

omega 3 fatty acids 

may enhance the anticoagulant effect of anticoagulants

dicumarol

may enhance the adverse/toxic effect of anticoagulants

heparin

may enhance the adverse/toxic effect of anticoagulants

dalteparin

may enhance the adverse/toxic effect of anticoagulants

dicoumarol

may enhance the adverse/toxic effect of anticoagulants

idarucizumab

may enhance the adverse/toxic effect of anticoagulants

cilostazol

may enhance the adverse/toxic effect of anticoagulants

clopidogrel

may enhance the adverse/toxic effect of anticoagulants

ticagrelor

may enhance the adverse/toxic effect of anticoagulants

naproxen 

may increase the anti-platelet effect of anti-coagulants agents

tirofiban

may have an increased anticoagulant effect when combined with Anticoagulants

bromeperidol 

bromeperidol increases the toxicity of anticoagulants

dasatinib 

it increases the effect of anticoagulants

magnesium salicylate 

may enhance the nephrotoxic effect of salicylates

selexipag

may have an increased adverse effect when combined with anticoagulants

iloperidone

may have an increased adverse effect when combined with anticoagulants

iloprost

may have an increased adverse effect when combined with anticoagulants

ibritumomab tiuxetan 

may have an increased adverse effect when combined with ibritumomab tiuxetan

rivaroxaban 

other antiplatelet agents increase the anticoagulative effect of rivaroxaban

tanshinone I

may enhance the effect of anticoagulants

rosmarinic acid

may enhance the effect of anticoagulants

caryophyllene

may enhance the effect of anticoagulants

ursolic acid

may enhance the effect of anticoagulants

cepharanthine

may enhance the effect of anticoagulants

defibrotide sodium

may enhance the effect of anticoagulants

antithrombin III 

may increase the anticoagulant effect when combined with heparin

acalabrutinib 

may have an increased anticoagulant effect when combined with anticoagulants

alemtuzumab 

may have an increased anticoagulant effect when combined with anticoagulants

anacaulase 

may have an increased anticoagulant effect when combined with anticoagulants

deferasirox 

may have an increasingly adverse effect when combined with deferasirox

chenodeoxycholic acid 

may have an increasingly adverse effect when combined with deoxycholic acid

apixaban

may decrease the therapeutic effect when combined with anticoagulants

edoxaban

may decrease the therapeutic effect when combined with anticoagulants

rivaroxaban

may decrease the therapeutic effect when combined with anticoagulants

nintedanib 

may have an increasingly adverse effect when combined with nintedanib

nitroglycerin 

may decrease the anticoagulant effect when combined with heparin

tipranavir 

may have an increased anticoagulant effect when combined with anticoagulants

obinutuzumab 

may have an increasingly adverse effect when combined with obinutuzumab

pirtobrutinib 

may have an increased anticoagulant effect when combined with anticoagulants

zanubrutinib 

may have an increasingly adverse effect when combined with anticoagulants

carbimazole

may reduce the anticoagulant effect

potassium perchlorate

may reduce the anticoagulant effect

choline magnesium trisalicylate

may enhance the anticoagulant effect

aspirin

may increase the anticoagulant effect of heparin

defibrotide sodium

may increase the anticoagulant effect of heparin

tirofiban

may increase the anticoagulant effect of heparin

vorapaxar

may increase the anticoagulant effect of heparin

acetylsalicylic acid

may increase the anticoagulant effect of heparin

factor X, human 

may decrease the therapeutic effect of factor X

ibrutinib 

may have an increasingly adverse effect when combined with anticoagulants

inotersen 

may have an increased anticoagulant effect when combined with anticoagulants

kanamycin 

may have an increased anticoagulant effect when combined with anticoagulants

lecanemab 

may have an increasingly adverse effect when combined with anticoagulants

palifermin 

may enhance the serum concentration of palifermin

maralixibat

may increase the levels of serum concentration

lenacapavir

may increase the levels of serum concentration

curcumin

may increase the levels of serum concentration

glecaprevir

may increase the levels of serum concentration

caspofungin

may increase the levels of serum concentration

maralixibat

may increase the levels of serum concentration

lenacapavir

may increase the levels of serum concentration

diacerein

may increase the levels of serum concentration

memantine/donepezil

may increase the levels of serum concentration

tranylcypromine

may increase the levels of serum concentration

zaltoprofen 

may enhance the anticoagulant effects of each other when combined

tolazoline

may enhance the hyperkalemic effect

captopril/hydrochlorothiazide

may enhance the hyperkalemic effect

mibefradil

may enhance the hyperkalemic effect

indoramin

may enhance the hyperkalemic effect

minoxidil topical

may enhance the hyperkalemic effect

sugammadex 

may increase the anticoagulant effect when combined

potassium

they decrease the effect of each other by pharmacodynamic antagonism

potassium acetate

they decrease the effect of each other by pharmacodynamic antagonism

potassium bicarbonate

they decrease the effect of each other by pharmacodynamic antagonism

potassium cation

they decrease the effect of each other by pharmacodynamic antagonism

potassium chloride

they decrease the effect of each other by pharmacodynamic antagonism

perindopril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

quinapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

ramipril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

rescinnamine

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

spirapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

doxapram

It may enhance the risk of adverse effects when combined with Respiratory Stimulants

parnaparin 

may increase the risk of haemorrhage with oral anticoagulants

dipyridamole 

may increase the risk of haemorrhage with oral anticoagulants

dextran 

may increase the risk of haemorrhage with oral anticoagulants

eplerenone 

eplerenone: they may increase the anticoagulant effect of anticoagulants

vitamin e 

vitamin E: they may increase the anticoagulant effect of anticoagulants

betamethasone (systemic)

corticosteroids: they may increase the anticoagulant effect of anticoagulants

budesonide (oral inhalation)

corticosteroids: they may increase the anticoagulant effect of anticoagulants

budesonide intranasal

corticosteroids: they may increase the anticoagulant effect of anticoagulants

budesonide (Topical)

corticosteroids: they may increase the anticoagulant effect of anticoagulants

beclomethasone (nasal)

corticosteroids: they may increase the anticoagulant effect of anticoagulants

beclomethasone (nasal)

corticosteroids j3: they may increase the anticoagulant effect of anticoagulants

fluticasone (topical)

corticosteroids j3: they may increase the anticoagulant effect of anticoagulants

beclomethasone dipropionate

corticosteroids j3: they may increase the anticoagulant effect of anticoagulants

fluticasone (nasal)

corticosteroids j3: they may increase the anticoagulant effect of anticoagulants

beclomethasone (nasal)

corticosteroids j4: they may increase the anticoagulant effect of anticoagulants

fluticasone (topical)

corticosteroids j4: they may increase the anticoagulant effect of anticoagulants

beclomethasone dipropionate

corticosteroids j4: they may increase the anticoagulant effect of anticoagulants

fluticasone (nasal)

corticosteroids j4: they may increase the anticoagulant effect of anticoagulants

ceritinib 

ceritinib: they may increase the anticoagulant effect of anticoagulants

The anticoagulant effects of ancord may be enhanced when administered concomitantly with other anticoagulants

aceclofenac/rabeprazole

may have an increased anticoagulant effect when combined with anticoagulants

anagrelide

other antiplatelet agents increase the anticoagulative effect of heparin

cilostazol

other antiplatelet agents increase the anticoagulative effect of heparin

demeclocycline

demeclocycline increases the effects of heparin by an unknown mechanism

doxycycline

doxycycline increases the effects of heparin by an unknown mechanism

caplacizumab 

caplacizumab has the potential to increase the anticoagulant activity of other anticoagulants

 

Dosage Forms & Strengths  

heparin lock solution  

100units/mL  

10units/mL  

2units/mL  

1unit/mL  

premixed IV solution  

25,000units/500mL  

25,000units/250mL  

20,000units/500mL  

12,500units/250mL  

injectable solution  

20,000units/mL  

10,000units/mL  

5000units/mL  

2500units/mL  

1000units/mL  

Deep Vein Thrombosis 

Prophylaxis
7500 units subcutaneous every 12 hours, OR
5000 units subcutaneous every 8-12hours
Treatment
Intravenous bolus of 80 units/kg, following continuous infusion of about 18 units/kg in hour, OR
subcutaneous injection 250 units/kg, following 250 units/kg for every 12 hours
5000 units Intravenous bolus, following continuous infusion of 1300 units/hr, OR
Dosing considerations
There are a number of concentrations available; caution is necessary to prevent the medication errors



Anticoagulants 

Intermittent intravenous injection
8000-10,000 units intravenous initially, following 50-70 units/kg (5000-10,000 units) every 4-6 hours
Continuous intravenous infusion
5000 units intravenous injection, then by continuous intravenous infusion of 20,000-40,000 units/24 hours
Dosing considerations
There are several concentrations available; extreme caution is necessary to prevent a medication error
When heparin is administered with warfarin sodium or dicumarol, a delay of 24 hours after the last subcutaneous dose or 5 hours after the last intravenous dose should be given before blood is collected if a prothrombin time is achieved.



Acute Coronary Syndrome 

PCI
Without the GPIIb or IIIa inhibitor: 70 to 100 unit/kg Intravenous bolus initially
With GPIIb or IIIa inhibitor: 50 to 70 units/kg Intravenous bolus initially
STEMI
Patient who are on fibrinolytics: IV bolus of 60 units/kg (maximum: 4000 units), following 12 units/kg in hour as continuous IV infusion (max 1000 units/hr)
The dose must be adjusted to keep the aPTT between 50 to 70 seconds
NSTEMI/Unstable Angina
6 to 70 units/kg intravenous bolus initially (maximum: 5000 units), following 12-15 units/kg in hour intravenous infusion initially (maximum: 1000 units/hr)
The dose must be adjusted to keep the aPTT between 50 to 70 secs
Dosing considerations
There are several concentrations available; extreme caution is necessary to prevent a medication error




Catheter Patency
Clot prevention in arterial and venous catheters
Use 100 units/mL; inject enough fluid to fill the catheter's lumen.
Dosing considerations
There are several concentrations available; caution is necessary to prevent a medication errors.
The amount and frequency are determined by the catheter capacity and type.
Peripheral heparin locks are normally flushed every 6-8 hours



Dose Adjustments

Dosing Modifications
Hepatic impairment: use Caution; dose adjustment is required


Catheter Patency
Clot prevention in arterial and venous catheters
Use 100 units/mL; inject enough fluid to fill the catheter's lumen.
Dosing considerations
There are several concentrations available; caution is necessary to prevent a medication errors.
The amount and frequency are determined by the catheter capacity and type.
Peripheral heparin locks are normally flushed every 6-8 hours



Dose Adjustments

Dosing Modifications
Hepatic impairment: use Caution; dose adjustment is required

 

Dosage Forms & Strengths  

injectable solution  

10,000units/mL  

5000units/mL  

1000units/mL  

heparin lock solution  

100units/mL  

10units/mL  

 

Refer to the adult dosing regimen  

Frequency defined  

>10%  

Possibly delayed, Heparin-induced thrombocytopenia (10-30%)  

Frequency not defined  

Hemorrhage  

Increased liver aminotransferase  

Immune hypersensitivity reaction  

Mild pain  

Injection site ulcer  

Anaphylaxis  

Osteoporosis  

Post marketing Reports  

Gasping syndrome  

Necrosis of skin  

serious adverse reactions  

Vascular disorders, including vasospastic reactions, contusion  

Delayed transient alopecia  

Rebound hyperlipemia  

heparin resistance  

Hypersensitivity  

Local irritation, mild pain, ulceration or hematoma, erythema  

Histamine-like reactions  

Hyperkalemia  

Priapism  

Black Box Warning

History of bleeding.  

Contraindication /Caution  

Contraindication:  

Known hypersensitivity to heparin or pork products (heparin is derived from porcine intestinal mucosa)  

Active major bleeding or conditions with a high risk of hemorrhage  

Severe thrombocytopenia (platelet count < 100,000/mm3)  

Uncontrolled arterial hypertension  

Intracranial hemorrhage (except when caused by anticoagulants)  

Bacterial endocarditis or other systemic infections  

Severe liver or kidney disease  

Recent eye, brain, or spinal cord surgery or lumbar puncture  

Caution:  

Active bleeding or a history of bleeding disorders  

Severe hypertension  

Severe liver or kidney disease  

Recent surgery or trauma  

Bacterial endocarditis  

Diabetes mellitus  

Eye or brain surgery  

Ulcerative colitis  

Elderly patients  

Women who are pregnant or breastfeeding  

Pregnancy/Lactation   

Pregnancy consideration: US FDA pregnancy category: Not assigned  

Lactation: Heparin is not known whether it is excreted into human milk  

Pregnancy category:  

  • Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.  
  • Category B: There is no evidence of risk to the fetus found in animal reproduction studies and there are not enough studies on pregnant women.  
  • Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.  
  • Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.  
  • Category X: Drugs listed in this category outweigh risks over benefits These category drugs should be prohibited for pregnant women.  
  • Category N: There is no data available for the drug under this category.  

Pharmacology: 

Heparin is a sulfate rich glycosaminoglycan, it is well known anticoagulant, since it binds to antithrombin III (serine protease inhibitor) that inactivates thrombin and factor Xa. 

Pharmacodynamics:  

Heparin makes use of antithrombin III thus enhancing the inhibitory activity of clotting factors such as thrombin and factor Xa. Upon binding to heparin, heparin induces conformational changes that increase facilitated the inhibitory effects of antithrombin III toward thrombin and factor Xa. This results in the anticlotting action that prevents the change from fibrinogen to fibrin and blood clotting.
The heparin crucial characteristics is its prompt action; it starts acting right after injection and within several minutes. Regarding its anticoagulant effect, the level of the efficacy may be assessed by activated partial thromboplastin time (aPTT) or anti-factor Xa activity. Depending on the dosage and mode of administration, its anticoagulant action has varying durations.  

Pharmacokinetics:  

Absorption  

when administered subcutaneously, heparin has a slow and partial absorption in the systemic circulation. The reaction begins after several days and is dose and site dependent. Heparin therapy levels are immediately achieved with intravenous injection. 

Distribution  

Heparin distributes in small volume since it binds with high affinity to plasma proteins such as antithrombin III. It does not cross the blood-brain barrier. 

Metabolism  

Heparin is not biotransformed in the liver or other organs. 

Elimination and excretion  

The reticuloendothelial system and, to a lesser extent, the kidneys remove heparin from the bloodstream. Heparin’s elimination half-life varies from 30 minutes to 2 hours and is dependent on dosage.  

Administration   

Heparin can be given intravenously, subcutaneously and as a continuous infusion. Choosing the route of administration depends on the intended purpose and the duration of the effect that is expected.  

Regarding the dosage and administration of heparin, it may differ depending on certain aspects: weight, age, as well as specific medical conditions.  

Patient information leaflet  

Generic Name: heparin  

Pronounced: [ HEP-a-rin ] 

Why do we use heparin?  

Heparin is employed for the purpose of anticoagulation, or the prevention of formation of blood clots. This can be used to treat and prevent disorders like pulmonary embolism and deep vein thrombosis in patients at high risk including those that are restricted to bed rest or have undergone surgery.  

Heparin is also used for treatment of certain types of acute myocardial infarction and unstable angina and as an anticoagulant for patients undergoing specific procedures like haemodialysis and blood transfusion. Also, heparin can help prevent possible blood clotting in people with atrial fibrillation or mechanical heart valves. 

Content loading

heparin

Brand Name :

Heparin Lock Flush (obsolete), Hep-Lock (obsolete), Hep-Pak (obsolete), Hep-Pak CVC (obsolete), Heparin Sodium ADD (Vantage) 

Synonyms :

heparin

Class :

Anticoagulants, Hematologic; Anticoagulants, Cardiovascular 

Mail Whatsapp PDF Image



No data available for drug.

Dosage Forms & Strengths  

heparin lock solution  

100units/mL  

10units/mL  

2units/mL  

1unit/mL  

premixed IV solution  

25,000units/500mL  

25,000units/250mL  

20,000units/500mL  

12,500units/250mL  

injectable solution  

20,000units/mL  

10,000units/mL  

5000units/mL  

2500units/mL  

1000units/mL  

Deep Vein Thrombosis 

Prophylaxis
7500 units subcutaneous every 12 hours, OR
5000 units subcutaneous every 8-12hours
Treatment
Intravenous bolus of 80 units/kg, following continuous infusion of about 18 units/kg in hour, OR
subcutaneous injection 250 units/kg, following 250 units/kg for every 12 hours
5000 units Intravenous bolus, following continuous infusion of 1300 units/hr, OR
Dosing considerations
There are a number of concentrations available; caution is necessary to prevent the medication errors



Anticoagulants 

Intermittent intravenous injection
8000-10,000 units intravenous initially, following 50-70 units/kg (5000-10,000 units) every 4-6 hours
Continuous intravenous infusion
5000 units intravenous injection, then by continuous intravenous infusion of 20,000-40,000 units/24 hours
Dosing considerations
There are several concentrations available; extreme caution is necessary to prevent a medication error
When heparin is administered with warfarin sodium or dicumarol, a delay of 24 hours after the last subcutaneous dose or 5 hours after the last intravenous dose should be given before blood is collected if a prothrombin time is achieved.



Acute Coronary Syndrome 

PCI
Without the GPIIb or IIIa inhibitor: 70 to 100 unit/kg Intravenous bolus initially
With GPIIb or IIIa inhibitor: 50 to 70 units/kg Intravenous bolus initially
STEMI
Patient who are on fibrinolytics: IV bolus of 60 units/kg (maximum: 4000 units), following 12 units/kg in hour as continuous IV infusion (max 1000 units/hr)
The dose must be adjusted to keep the aPTT between 50 to 70 seconds
NSTEMI/Unstable Angina
6 to 70 units/kg intravenous bolus initially (maximum: 5000 units), following 12-15 units/kg in hour intravenous infusion initially (maximum: 1000 units/hr)
The dose must be adjusted to keep the aPTT between 50 to 70 secs
Dosing considerations
There are several concentrations available; extreme caution is necessary to prevent a medication error




Catheter Patency
Clot prevention in arterial and venous catheters
Use 100 units/mL; inject enough fluid to fill the catheter's lumen.
Dosing considerations
There are several concentrations available; caution is necessary to prevent a medication errors.
The amount and frequency are determined by the catheter capacity and type.
Peripheral heparin locks are normally flushed every 6-8 hours



Dose Adjustments

Dosing Modifications
Hepatic impairment: use Caution; dose adjustment is required


Catheter Patency
Clot prevention in arterial and venous catheters
Use 100 units/mL; inject enough fluid to fill the catheter's lumen.
Dosing considerations
There are several concentrations available; caution is necessary to prevent a medication errors.
The amount and frequency are determined by the catheter capacity and type.
Peripheral heparin locks are normally flushed every 6-8 hours



Dose Adjustments

Dosing Modifications
Hepatic impairment: use Caution; dose adjustment is required

Dosage Forms & Strengths  

injectable solution  

10,000units/mL  

5000units/mL  

1000units/mL  

heparin lock solution  

100units/mL  

10units/mL  

Refer to the adult dosing regimen  

DRUG INTERACTION

heparin

&

heparin + 

Severity : Monitor Closely
The anticoagulant effects of ancord may be enhanced when administered concomitantly with other anticoagulants

aspirin

may have an increased anticoagulant effect when combined with Heparin

defibrotide sodium

may have an increased anticoagulant effect when combined with Heparin

tirofiban

may have an increased anticoagulant effect when combined with Heparin

vorapaxar

may have an increased anticoagulant effect when combined with Heparin

acetylsalicylic acid

may have an increased anticoagulant effect when combined with Heparin

tanshinone I

may have an increased anticoagulant effect when combined with heparin

rosmarinic acid

may have an increased anticoagulant effect when combined with heparin

caryophyllene

may have an increased anticoagulant effect when combined with heparin

ursolic acid

may have an increased anticoagulant effect when combined with heparin

cepharanthine

may have an increased anticoagulant effect when combined with heparin

clopidogrel

may have an increased anticoagulant effect when combined with heparin

ticagrelor

may have an increased anticoagulant effect when combined with heparin

aceclofenac/rabeprazole

may have an increased anticoagulant effect when combined with heparin

tanshinone I

may have an increased anticoagulant effect when combined with heparin

rosmarinic acid

may have an increased anticoagulant effect when combined with heparin

caryophyllene

may have an increased anticoagulant effect when combined with heparin

ursolic acid

may have an increased anticoagulant effect when combined with heparin

aspirin

may have an increased anticoagulant effect when combined with heparin

defibrotide sodium

may have an increased anticoagulant effect when combined with heparin

tirofiban

may have an increased anticoagulant effect when combined with heparin

vorapaxar

may have an increased anticoagulant effect when combined with heparin

acetylsalicylic acid

may have an increased anticoagulant effect when combined with heparin

diacerein

heparin: it may enhance the toxic effect of Anti-Inflammatory Agents

diphenhydramine/ibuprofen

heparin: it may enhance the toxic effect of Anti-Inflammatory Agents

aspirin, chlorpheniramine, and phenylephrine

heparin: it may enhance the toxic effect of Anti-Inflammatory Agents

saccharomyces boulardii

heparin: it may enhance the toxic effect of Anti-Inflammatory Agents

diroximel fumarate

heparin: it may enhance the toxic effect of Anti-Inflammatory Agents

anagrelide

may have an increased anticoagulant effect when combined with heparin

cilostazol

may have an increased anticoagulant effect when combined with heparin

prasugrel 

may increase the anti-coagulant effect of anti-platelet agents

aspirin/dipyridamole 

may increase the anti-coagulant effect of antiplatelet agents

mefenamic acid 

may increase the anti-coagulant effect of nonsteroidal anti-inflammatory agents

alfalfa 

may increase the anticoagulation effect when combined

desirudin 

desirubin: they may increase the anticoagulant effect of anticoagulants

anagrelide

may have an increased anticoagulant effect when combined with heparin

cilostazol

may have an increased anticoagulant effect when combined with heparin

aceclofenac/rabeprazole

may have an increased anticoagulant effect when combined with heparin

tanshinone I

may have an increased anticoagulant effect when combined with heparin

rosmarinic acid

may have an increased anticoagulant effect when combined with heparin

caryophyllene

may have an increased anticoagulant effect when combined with heparin

ursolic acid

may have an increased anticoagulant effect when combined with heparin

taheebo 

due to anticoagulant properties of taheebo, other anticoagulant use is contraindicated

bladderwrack 

use caution when bladderwrack is used in combination with anticoagulant medication due to antiplatelet action

bloodroot 

bloodroot along with anticoagulant medications will result in bleeding and bruising

indomethacin 

when combined, may increase anticoagulation

aceclofenac/rabeprazole

may have an increased anticoagulant effect when combined with heparin

oritavancin 

may decrease the therapeutic effect when combined with heparin

piperacillin

piperacillin will increase the effectiveness of heparin by anticoagulation

cefotetan

when both drugs are combined, there may be an increased effect of heparin by anticoagulation  

ceftriaxone

when both drugs are combined, there may be an increased effect of heparin by anticoagulation  

azithromycin

azithromycin decreases the metabolism of heparin and increases its effect

edoxaban 

may enhance the toxicity of the other through anti coagulation

hemin 

may enhance the effect of anticoagulants

edoxaban 

edoxaban increases the effect of anticoagulants

mifepristone 

it increases the toxicity of anticoagulants

omacetaxine 

anticoagulants increase the toxicity of omacetaxine

vorapaxar 

vorapaxar increases the toxicity of anticoagulants

apixaban 

may have an increased anticoagulant effect when combined with anticoagulants

corticorelin 

may have an increasingly adverse effect when combined with corticorelin

telavancin 

may decrease the therapeutic effect when combined with heparin

dabigatran 

may have an increased anticoagulant effect when combined with anticoagulants

pirfenidone

may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex

urokinase 

urokinase: they may increase the anticoagulant effect of anticoagulants

butabarbital 

the activity of heparin is reduced by butabarbital by enhancing metabolism

defibrotide sodium

thrombolytic Agents may enhance the anticoagulant effect of anticoagulants

azilsartan medoxomil

it increases the effect of hyperkalemia of angiotensin II receptor blockers

candesartan cilexetil

it increases the effect of hyperkalemia of angiotensin II receptor blockers

eprosartan

it increases the effect of hyperkalemia of angiotensin II receptor blockers

irbesartan

it increases the effect of hyperkalemia of angiotensin II receptor blockers

losartan

it increases the effect of hyperkalemia of angiotensin II receptor blockers

dicumarol

may enhance the adverse/toxic effect of anticoagulants

heparin

may enhance the adverse/toxic effect of anticoagulants

dalteparin

may enhance the adverse/toxic effect of anticoagulants

dicoumarol

may enhance the adverse/toxic effect of anticoagulants

idarucizumab

may enhance the adverse/toxic effect of anticoagulants

aspirin

other antiplatelet agents increase the effect of anticoagulating agents

defibrotide sodium

other antiplatelet agents increase the effect of anticoagulating agents

cilostazol

other antiplatelet agents increase the effect of anticoagulating agents

clopidogrel

other antiplatelet agents increase the effect of anticoagulating agents

ticagrelor

other antiplatelet agents increase the effect of anticoagulating agents

tirofiban

may have an increased anticoagulant effect when combined with anticoagulants

vorapaxar

may have an increased anticoagulant effect when combined with anticoagulants

acetylsalicylic acid

may have an increased anticoagulant effect when combined with anticoagulants

aliskiren 

may have an increased hyperkalemic effect when combined with aliskiren

telmisartan

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

valsartan

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

azilsartan medoxomil

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

candesartan cilexetil

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

eprosartan

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

spirapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

trandolapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

zofenopril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

benazepril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

captopril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

eplerenone 

may have an increased hyperkalemic effect when combined with eplerenone

levothyroxine 

may diminish the serum concentration when combined with levothyroxine

palifermin 

may enhance the serum concentration when combined with palifermin

pentoxifylline 

may have an increased anticoagulant effect when combined with heparin

spironolactone and hydrochlorothiazide

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

amiloride/hydrochlorothiazide

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

amiloride

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

canrenoic acid

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

eplerenone

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

mipomersen 

It may enhance the toxicity when combined with mipomersen

omega 3 carboxylic acids 

It may enhance the risk of bleeding by affecting coagulation when combined with omega-3 carboxylic acids

tanshinone I

nonsteroidal anti-Inflammatory agents may strengthen the anticoagulant effects of anticoagulants

rosmarinic acid

nonsteroidal anti-Inflammatory agents may strengthen the anticoagulant effects of anticoagulants

caryophyllene

nonsteroidal anti-Inflammatory agents may strengthen the anticoagulant effects of anticoagulants

ursolic acid

nonsteroidal anti-Inflammatory agents may strengthen the anticoagulant effects of anticoagulants

cepharanthine

nonsteroidal anti-Inflammatory agents may strengthen the anticoagulant effects of anticoagulants

anagrelide

antiplatelet agents increase the effect of anticoagulants

azilsartan medoxomil

heparins: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers

candesartan cilexetil

heparins: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers

eprosartan

heparins: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers

irbesartan

heparins: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers

losartan

heparins: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers

amprenavir

It may enhance the serum concentration when combined with CYP3A4 Substrates

fostemsavir

It may enhance the serum concentration when combined with CYP3A4 Substrates

indinavir

It may enhance the serum concentration when combined with CYP3A4 Substrates

acenocoumarol

may have an increased anticoagulant effect when combined with vitamin k antagonists

fluindione

may have an increased anticoagulant effect when combined with vitamin k antagonists

phenindione

may have an increased anticoagulant effect when combined with vitamin k antagonists

phylloquinone

may have an increased anticoagulant effect when combined with vitamin k antagonists

warfarin

may have an increased anticoagulant effect when combined with vitamin k antagonists

iloperidone

It may diminish the metabolism when combined with Heparins

iloprost

It may diminish the metabolism when combined with Heparins

selexipag

It may diminish the metabolism when combined with Heparins

betamethasone (systemic)

It may enhance the risk of adverse effects when combined with Anticoagulants

budesonide (oral inhalation)

It may enhance the risk of adverse effects when combined with Anticoagulants

budesonide intranasal

It may enhance the risk of adverse effects when combined with Anticoagulants

budesonide (Topical)

It may enhance the risk of adverse effects when combined with Anticoagulants

beclomethasone (nasal)

It may enhance the risk of adverse effects when combined with Anticoagulants

spironolactone and hydrochlorothiazide

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

amiloride/hydrochlorothiazide

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

eplerenone

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

spironolactone

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

triamterene

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

amiloride

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

canrenoic acid

may have an increased hyperkalemic effect when combined with potassium-sparing diuretics

when andexanet alfa is used with heparin, its therapeutic efficacy may be reduced

olmesartan

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

telmisartan

may have an increased hyperkalemic effect when combined with angiotensin ii receptor blockers

perindopril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

quinapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

ramipril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

rescinnamine

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

spirapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

pinacidil

may have an increased hyperkalemic effect when combined with potassium salts

soyabean oil 

heparin: it may decrease the therapeutic efficacy of soyabean oil

coleus 

both forskolin and heparin enhance anticoagulation

azathioprine

reduce therapeutic effects of heparin

gemcitabine

gemcitabine, by the unspecific reactions, increases the effect of heparin

fluorouracil

the effect of heparin is increased by fluorouracil with the help of an unspecific interaction mechanism

potassium iodide

it increases the effect of hyperkalemia in potassium salts

vitamin e

it may increase the action of anticoagulant effect

fluvoxamine

it may increase the effect of anticoagulants

aspirin

it may enhance the anticoagulant effect of anticoagulants

defibrotide sodium

it may enhance the anticoagulant effect of anticoagulants

acetylsalicylic acid

it may enhance the anticoagulant effect of anticoagulants

anagrelide

it may enhance the anticoagulant effect of anticoagulants

cilostazol

it may enhance the anticoagulant effect of anticoagulants

escitalopram

antiplatelet agents increase the effect of anticoagulants

fluoxetine

antiplatelet agents increase the effect of anticoagulants

choline magnesium trisalicylate

salicylates may enhance the anticoagulant effect of anticoagulants

iloperidone

may enhance the adverse/toxic effect of anticoagulants

iloprost

may enhance the adverse/toxic effect of anticoagulants

selexipag

may enhance the adverse/toxic effect of anticoagulants

aspirin

may increase the anticoagulant effect of anticoagulants

defibrotide sodium

may increase the anticoagulant effect of anticoagulants

vorapaxar

may increase the anticoagulant effect of anticoagulants

acetylsalicylic acid

may increase the anticoagulant effect of anticoagulants

anagrelide

may increase the anticoagulant effect of anticoagulants

iloprost 

may increase the toxic effect of prostacyclin analogs

omega 3 fatty acids 

may enhance the anticoagulant effect of anticoagulants

dicumarol

may enhance the adverse/toxic effect of anticoagulants

heparin

may enhance the adverse/toxic effect of anticoagulants

dalteparin

may enhance the adverse/toxic effect of anticoagulants

dicoumarol

may enhance the adverse/toxic effect of anticoagulants

idarucizumab

may enhance the adverse/toxic effect of anticoagulants

cilostazol

may enhance the adverse/toxic effect of anticoagulants

clopidogrel

may enhance the adverse/toxic effect of anticoagulants

ticagrelor

may enhance the adverse/toxic effect of anticoagulants

naproxen 

may increase the anti-platelet effect of anti-coagulants agents

tirofiban

may have an increased anticoagulant effect when combined with Anticoagulants

bromeperidol 

bromeperidol increases the toxicity of anticoagulants

dasatinib 

it increases the effect of anticoagulants

magnesium salicylate 

may enhance the nephrotoxic effect of salicylates

selexipag

may have an increased adverse effect when combined with anticoagulants

iloperidone

may have an increased adverse effect when combined with anticoagulants

iloprost

may have an increased adverse effect when combined with anticoagulants

ibritumomab tiuxetan 

may have an increased adverse effect when combined with ibritumomab tiuxetan

rivaroxaban 

other antiplatelet agents increase the anticoagulative effect of rivaroxaban

tanshinone I

may enhance the effect of anticoagulants

rosmarinic acid

may enhance the effect of anticoagulants

caryophyllene

may enhance the effect of anticoagulants

ursolic acid

may enhance the effect of anticoagulants

cepharanthine

may enhance the effect of anticoagulants

defibrotide sodium

may enhance the effect of anticoagulants

antithrombin III 

may increase the anticoagulant effect when combined with heparin

acalabrutinib 

may have an increased anticoagulant effect when combined with anticoagulants

alemtuzumab 

may have an increased anticoagulant effect when combined with anticoagulants

anacaulase 

may have an increased anticoagulant effect when combined with anticoagulants

deferasirox 

may have an increasingly adverse effect when combined with deferasirox

chenodeoxycholic acid 

may have an increasingly adverse effect when combined with deoxycholic acid

apixaban

may decrease the therapeutic effect when combined with anticoagulants

edoxaban

may decrease the therapeutic effect when combined with anticoagulants

rivaroxaban

may decrease the therapeutic effect when combined with anticoagulants

nintedanib 

may have an increasingly adverse effect when combined with nintedanib

nitroglycerin 

may decrease the anticoagulant effect when combined with heparin

tipranavir 

may have an increased anticoagulant effect when combined with anticoagulants

obinutuzumab 

may have an increasingly adverse effect when combined with obinutuzumab

pirtobrutinib 

may have an increased anticoagulant effect when combined with anticoagulants

zanubrutinib 

may have an increasingly adverse effect when combined with anticoagulants

carbimazole

may reduce the anticoagulant effect

potassium perchlorate

may reduce the anticoagulant effect

choline magnesium trisalicylate

may enhance the anticoagulant effect

aspirin

may increase the anticoagulant effect of heparin

defibrotide sodium

may increase the anticoagulant effect of heparin

tirofiban

may increase the anticoagulant effect of heparin

vorapaxar

may increase the anticoagulant effect of heparin

acetylsalicylic acid

may increase the anticoagulant effect of heparin

factor X, human 

may decrease the therapeutic effect of factor X

ibrutinib 

may have an increasingly adverse effect when combined with anticoagulants

inotersen 

may have an increased anticoagulant effect when combined with anticoagulants

kanamycin 

may have an increased anticoagulant effect when combined with anticoagulants

lecanemab 

may have an increasingly adverse effect when combined with anticoagulants

palifermin 

may enhance the serum concentration of palifermin

maralixibat

may increase the levels of serum concentration

lenacapavir

may increase the levels of serum concentration

curcumin

may increase the levels of serum concentration

glecaprevir

may increase the levels of serum concentration

caspofungin

may increase the levels of serum concentration

maralixibat

may increase the levels of serum concentration

lenacapavir

may increase the levels of serum concentration

diacerein

may increase the levels of serum concentration

memantine/donepezil

may increase the levels of serum concentration

tranylcypromine

may increase the levels of serum concentration

zaltoprofen 

may enhance the anticoagulant effects of each other when combined

tolazoline

may enhance the hyperkalemic effect

captopril/hydrochlorothiazide

may enhance the hyperkalemic effect

mibefradil

may enhance the hyperkalemic effect

indoramin

may enhance the hyperkalemic effect

minoxidil topical

may enhance the hyperkalemic effect

sugammadex 

may increase the anticoagulant effect when combined

potassium

they decrease the effect of each other by pharmacodynamic antagonism

potassium acetate

they decrease the effect of each other by pharmacodynamic antagonism

potassium bicarbonate

they decrease the effect of each other by pharmacodynamic antagonism

potassium cation

they decrease the effect of each other by pharmacodynamic antagonism

potassium chloride

they decrease the effect of each other by pharmacodynamic antagonism

perindopril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

quinapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

ramipril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

rescinnamine

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

spirapril

may have an increased hyperkalemic effect when combined with angiotensin-converting enzyme inhibitors

doxapram

It may enhance the risk of adverse effects when combined with Respiratory Stimulants

parnaparin 

may increase the risk of haemorrhage with oral anticoagulants

dipyridamole 

may increase the risk of haemorrhage with oral anticoagulants

dextran 

may increase the risk of haemorrhage with oral anticoagulants

eplerenone 

eplerenone: they may increase the anticoagulant effect of anticoagulants

vitamin e 

vitamin E: they may increase the anticoagulant effect of anticoagulants

betamethasone (systemic)

corticosteroids: they may increase the anticoagulant effect of anticoagulants

budesonide (oral inhalation)

corticosteroids: they may increase the anticoagulant effect of anticoagulants

budesonide intranasal

corticosteroids: they may increase the anticoagulant effect of anticoagulants

budesonide (Topical)

corticosteroids: they may increase the anticoagulant effect of anticoagulants

beclomethasone (nasal)

corticosteroids: they may increase the anticoagulant effect of anticoagulants

beclomethasone (nasal)

corticosteroids j3: they may increase the anticoagulant effect of anticoagulants

fluticasone (topical)

corticosteroids j3: they may increase the anticoagulant effect of anticoagulants

beclomethasone dipropionate

corticosteroids j3: they may increase the anticoagulant effect of anticoagulants

fluticasone (nasal)

corticosteroids j3: they may increase the anticoagulant effect of anticoagulants

beclomethasone (nasal)

corticosteroids j4: they may increase the anticoagulant effect of anticoagulants

fluticasone (topical)

corticosteroids j4: they may increase the anticoagulant effect of anticoagulants

beclomethasone dipropionate

corticosteroids j4: they may increase the anticoagulant effect of anticoagulants

fluticasone (nasal)

corticosteroids j4: they may increase the anticoagulant effect of anticoagulants

ceritinib 

ceritinib: they may increase the anticoagulant effect of anticoagulants

The anticoagulant effects of ancord may be enhanced when administered concomitantly with other anticoagulants

aceclofenac/rabeprazole

may have an increased anticoagulant effect when combined with anticoagulants

anagrelide

other antiplatelet agents increase the anticoagulative effect of heparin

cilostazol

other antiplatelet agents increase the anticoagulative effect of heparin

demeclocycline

demeclocycline increases the effects of heparin by an unknown mechanism

doxycycline

doxycycline increases the effects of heparin by an unknown mechanism

caplacizumab 

caplacizumab has the potential to increase the anticoagulant activity of other anticoagulants

Actions and Spectrum:
Heparin is a naturally occurring anticoagulant in the blood that enhances the action of the antithrombin III that inhibits the blood clot.  

Heparin is a powerful anticoagulant and is used in different pathologic states involving formation of blood clots, like postoperative state, deep vein thrombosis, pulmonary embolism and myocardial infarction. It is also used in surgeries involving heart bypass, and dialysis to avert the formation of blood clots. Moreover, it is employed as a preventive agent in high cardiovascular risk patients who have atrial fibrillation and as the therapy for patients with DIC and the antiphospholipid syndrome.

Frequency defined  

>10%  

Possibly delayed, Heparin-induced thrombocytopenia (10-30%)  

Frequency not defined  

Hemorrhage  

Increased liver aminotransferase  

Immune hypersensitivity reaction  

Mild pain  

Injection site ulcer  

Anaphylaxis  

Osteoporosis  

Post marketing Reports  

Gasping syndrome  

Necrosis of skin  

serious adverse reactions  

Vascular disorders, including vasospastic reactions, contusion  

Delayed transient alopecia  

Rebound hyperlipemia  

heparin resistance  

Hypersensitivity  

Local irritation, mild pain, ulceration or hematoma, erythema  

Histamine-like reactions  

Hyperkalemia  

Priapism  

Black Box Warning

History of bleeding.  

Contraindication /Caution  

Contraindication:  

Known hypersensitivity to heparin or pork products (heparin is derived from porcine intestinal mucosa)  

Active major bleeding or conditions with a high risk of hemorrhage  

Severe thrombocytopenia (platelet count < 100,000/mm3)  

Uncontrolled arterial hypertension  

Intracranial hemorrhage (except when caused by anticoagulants)  

Bacterial endocarditis or other systemic infections  

Severe liver or kidney disease  

Recent eye, brain, or spinal cord surgery or lumbar puncture  

Caution:  

Active bleeding or a history of bleeding disorders  

Severe hypertension  

Severe liver or kidney disease  

Recent surgery or trauma  

Bacterial endocarditis  

Diabetes mellitus  

Eye or brain surgery  

Ulcerative colitis  

Elderly patients  

Women who are pregnant or breastfeeding  

Pregnancy/Lactation   

Pregnancy consideration: US FDA pregnancy category: Not assigned  

Lactation: Heparin is not known whether it is excreted into human milk  

Pregnancy category:  

  • Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.  
  • Category B: There is no evidence of risk to the fetus found in animal reproduction studies and there are not enough studies on pregnant women.  
  • Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.  
  • Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.  
  • Category X: Drugs listed in this category outweigh risks over benefits These category drugs should be prohibited for pregnant women.  
  • Category N: There is no data available for the drug under this category.  

Pharmacology: 

Heparin is a sulfate rich glycosaminoglycan, it is well known anticoagulant, since it binds to antithrombin III (serine protease inhibitor) that inactivates thrombin and factor Xa. 

Pharmacodynamics:  

Heparin makes use of antithrombin III thus enhancing the inhibitory activity of clotting factors such as thrombin and factor Xa. Upon binding to heparin, heparin induces conformational changes that increase facilitated the inhibitory effects of antithrombin III toward thrombin and factor Xa. This results in the anticlotting action that prevents the change from fibrinogen to fibrin and blood clotting.
The heparin crucial characteristics is its prompt action; it starts acting right after injection and within several minutes. Regarding its anticoagulant effect, the level of the efficacy may be assessed by activated partial thromboplastin time (aPTT) or anti-factor Xa activity. Depending on the dosage and mode of administration, its anticoagulant action has varying durations.  

Pharmacokinetics:  

Absorption  

when administered subcutaneously, heparin has a slow and partial absorption in the systemic circulation. The reaction begins after several days and is dose and site dependent. Heparin therapy levels are immediately achieved with intravenous injection. 

Distribution  

Heparin distributes in small volume since it binds with high affinity to plasma proteins such as antithrombin III. It does not cross the blood-brain barrier. 

Metabolism  

Heparin is not biotransformed in the liver or other organs. 

Elimination and excretion  

The reticuloendothelial system and, to a lesser extent, the kidneys remove heparin from the bloodstream. Heparin’s elimination half-life varies from 30 minutes to 2 hours and is dependent on dosage.  

Administration   

Heparin can be given intravenously, subcutaneously and as a continuous infusion. Choosing the route of administration depends on the intended purpose and the duration of the effect that is expected.  

Regarding the dosage and administration of heparin, it may differ depending on certain aspects: weight, age, as well as specific medical conditions.  

Patient information leaflet  

Generic Name: heparin  

Pronounced: [ HEP-a-rin ] 

Why do we use heparin?  

Heparin is employed for the purpose of anticoagulation, or the prevention of formation of blood clots. This can be used to treat and prevent disorders like pulmonary embolism and deep vein thrombosis in patients at high risk including those that are restricted to bed rest or have undergone surgery.  

Heparin is also used for treatment of certain types of acute myocardial infarction and unstable angina and as an anticoagulant for patients undergoing specific procedures like haemodialysis and blood transfusion. Also, heparin can help prevent possible blood clotting in people with atrial fibrillation or mechanical heart valves. 

Latest Posts


Free CME credits

Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.

Digital Certificate PDF

On course completion, you will receive a full-sized presentation quality digital certificate.

medtigo Simulation

A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.

medtigo Points

medtigo points is our unique point redemption system created to award users for interacting on our site. These points can be redeemed for special discounts on the medtigo marketplace as well as towards the membership cost itself.
 
  • Registration with medtigo = 10 points
  • 1 visit to medtigo’s website = 1 point
  • Interacting with medtigo posts (through comments/clinical cases etc.) = 5 points
  • Attempting a game = 1 point
  • Community Forum post/reply = 5 points

    *Redemption of points can occur only through the medtigo marketplace, courses, or simulation system. Money will not be credited to your bank account. 10 points = $1.

All Your Certificates in One Place

When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.

Our Certificate Courses