Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Midamor
Synonyms :
Amidal,amiloberag
Class :
Diuretics & potassium-sparing
Brand Name :
Midamor
Synonyms :
Amidal,amiloberag
Class :
Diuretics & potassium-sparing
Dosage Forms & Strengths
Tablet
5mg
Maintenance dose :
5
mg
Tablet
Orally 
every 24 hours
5-10mg orally every 24hours
Congestive Heart Failure (CHF)Â
maintenance dose:
5
mg
Tablet
Orally 
every 24 hours
5-10mg orally every 24hours
maintenance dose:
5
mg
Tablet
Orally 
5-10mg orally every 24hours
Dosage Forms & Strengths
Data not established
5-10 mg orally per day
may diminish the absorption of thiazide diuretics
may increase the hyperkalemic effect of potassium salts
amiloride when administered with cycloserine increases the amount of potassium levels
may diminish the excretion when combined with lithium
may diminish the excretion when combined with lithium
amiloride: it may increase the risk of methemoglobinemia agents
amiloride: it may increase the risk of methemoglobinemia agents
amiloride: it may increase the risk of methemoglobinemia agents
amiloride: it may increase the risk of methemoglobinemia agents
amiloride: it may increase the risk of methemoglobinemia agents
Causes Hypokalemia.
may diminish the absorption when combined with thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may diminish the excretion of thiazide diuretics
may diminish the excretion of thiazide diuretics
may have an increased hyperkalemic effect when combined with potassium-sparing diuretics
it may enhance the effects when combined with lofexidine by pharmacodynamic synergism
the activity of amiloride can be increased when taken with trilaciclib
Concomitant use of these two drugs is not advised as the minimal renal damage may lead to fatal or life-threatening risks
may have an increased hyperkalemia when combined with amiloride
angiotensin II Receptor Blockers may enhance the hyperkalemic effect of potassium-Sparing Diuretics
angiotensin II Receptor Blockers may enhance the hyperkalemic effect of potassium-Sparing Diuretics
angiotensin II Receptor Blockers may enhance the hyperkalemic effect of potassium-Sparing Diuretics
angiotensin II Receptor Blockers may enhance the hyperkalemic effect of potassium-Sparing Diuretics
angiotensin II Receptor Blockers may enhance the hyperkalemic effect of potassium-Sparing Diuretics
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may enhance the hyperkalemic effect of ACE Inhibitors
may increase the hyperkalemic effect of ACE Inhibitors
may increase the hyperkalemic effect of ACE Inhibitors
may increase the hyperkalemic effect of ACE Inhibitors
may increase the hyperkalemic effect of ACE Inhibitors
may increase the hyperkalemic effect of ACE Inhibitors
may diminish the therapeutic effect
may diminish the therapeutic effect
may diminish the therapeutic effect
may diminish the therapeutic effect
may diminish the therapeutic effect
Combining amiloride with levobetaxolol may enhance the risk or seriousness of hyperkalemia
The potential for hyperkalemia to occur may be enhanced when amiloride is used concurrently with mibefradil
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may decrease the therapeutic effect when combined with antidiabetic agents
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may diminish the excretion when combined with calcium salts
may diminish the excretion when combined with calcium salts
may diminish the excretion when combined with calcium salts
may diminish the excretion when combined with calcium salts
may diminish the excretion when combined with calcium salts
administration of amiloride with spironolactone may increase the levels of potassium
Increase in the activity may be noticed when these two drugs are co-administered due to pharmacodynamic synergism
serum concentrations of potassium may be increased by amiloride and decreased by chlorthalidone when administered concomitantly
The exact interaction is not known, hence monitor closely
the effects of amiloride may be increased by carbidopa
Monitor when these drugs are used concomitantly
an increase in serum concentration of potassium can be noticed when amiloride is administered with metoprolol
digoxin when administered with amiloride can increase the serum levels of potassium
may have an increased hypercalcemic effect when combined with vitamin D analogs
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may diminish the excretion when combined with calcium salts
may diminish the excretion when combined with calcium salts
may diminish the excretion when combined with calcium salts
may have an increased adverse effect when combined with cardiac glycosides
may have an increased adverse effect when combined with cardiac glycosides
may have an increased adverse effect when combined with cardiac glycosides
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
may diminish the excretion when combined with calcium salts
antihypertensive actions of potassium-sparing diuretics can be reduced with combined NSAIDs
antihypertensive actions of potassium-sparing diuretics can be reduced with combined NSAIDs
antihypertensive actions of potassium-sparing diuretics can be reduced with combined NSAIDs
antihypertensive actions of potassium-sparing diuretics can be reduced with combined NSAIDs
antihypertensive actions of potassium-sparing diuretics can be reduced with combined NSAIDs
may have an increased hypotensive effect when combined with angiotensin-converting enzyme inhibitors
the therapeutic efficacy of amiloride can be decreased when used in combination with oxycodone
amiloride: it may increase the excretion rate of acrivastine
amiloride may enhance the excretion rate of almasilate, potentially lowering serum levels and reducing efficacy
NSAIDsmay diminish the antihypertensive effect of Potassium-Sparing Diuretics
NSAIDsmay diminish the antihypertensive effect of Potassium-Sparing Diuretics
NSAIDsmay diminish the antihypertensive effect of Potassium-Sparing Diuretics
NSAIDsmay diminish the antihypertensive effect of Potassium-Sparing Diuretics
NSAIDsmay diminish the antihypertensive effect of Potassium-Sparing Diuretics
it enhances the serum potassium levels
may increase the hyperkalemic effect of diuretics
may increase the hyperkalemic effect of angiotensin receptor II blockers
may increase the toxic effect of angiotensin receptor II blockers
may decrease the anti-hypertensive effect of nonsteroidal anti-inflammatory agents
may increase the hyperkalemic effect when combined with potassium-sparing diuretics
may have an increased hyperkalemic effect when combined with potassium-sparing diuretics
drospirenone/ethinyl estradiol/levomefolateÂ
may increase the hyperkalemic effect of Drospirenone-Containing Products
may decrease the therapeutic effect of Antidiabetic Agents
may decrease the therapeutic effect of Antidiabetic Agents
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
Angiotensin II Receptor Blockers: they may increase the hyperkalemic effect of potassium-sparing diuretics
Angiotensin II Receptor Blockers: they may increase the hyperkalemic effect of potassium-sparing diuretics
Angiotensin II Receptor Blockers: they may increase the hyperkalemic effect of potassium-sparing diuretics
Angiotensin II Receptor Blockers: they may increase the hyperkalemic effect of potassium-sparing diuretics
Angiotensin II Receptor Blockers: they may increase the hyperkalemic effect of potassium-sparing diuretics
may enhance the hyperkalemic effect
may enhance the hyperkalemic effect
may enhance the hyperkalemic effect
may enhance the concentration of serum when combined with thiazide diuretics
may enhance the concentration of serum when combined with thiazide diuretics
may enhance the concentration of serum when combined with thiazide diuretics
may enhance the concentration of serum when combined with thiazide diuretics
may enhance the concentration of serum when combined with thiazide diuretics
may diminish the calcium salts excretion
may diminish the calcium salts excretion
may diminish the calcium salts excretion
may diminish the calcium salts excretion
may diminish the calcium salts excretion
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect when combined with thiazide diuretics
may increase the hypokalemic effect when combined with thiazide diuretics
may have an increased hyperkalemic effect when combined with potassium-sparing diuretics
may have an increased hyperkalemic effect when combined with potassium-sparing diuretics
may have an increased orthostatic hypotensive effect when combined with thiazide diuretics
may have an increased hyperkalemic effect when combined with potassium-sparing diuretics
may have an increased hyperkalemic effect when combined with potassium-sparing diuretics
may have an increased hyperkalemic effect when combined with potassium-sparing diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may increase the hypokalemic effect of thiazide diuretics
may diminish the excretion when combined with thiazide diuretics
may diminish the excretion when combined with thiazide diuretics
an increase in the severity of hyperkalemia, blood pressure, and kidney failure may be seen when kebuzone is administered with amiloride
an increase in the severity of hypertension, kidney failure, or hyperkalemia may be seen when mofebutazone is administered with amiloride
the risk of hypertension, hyperkalemia, or renal failure may be increased
may decrease the therapeutic effect when combined with antidiabetic agents
may decrease the therapeutic effect when combined with antidiabetic agents
may decrease the therapeutic effect when combined with antidiabetic agents
may decrease the therapeutic effect when combined with antidiabetic agents
may decrease the therapeutic effect when combined with antidiabetic agents
the serum levels of potassium may be increased
the risk of dehydration can be increased
the risk of cardiac arrhythmia may be increased
the hypotensive activity of Remikiren may be increased
the risk of hyperkalemia and hypotension may be increased
may diminish the therapeutic efficacy of each other when combined
may diminish the therapeutic efficacy of each other when combined
may diminish the therapeutic efficacy of each other when combined
may diminish the therapeutic efficacy of each other when combined
may diminish the therapeutic efficacy of each other when combined
the therapeutic activity of amiloride may be reduced
amiloride elevates magnesium hydroxide levels by decreasing renal clearance
lansoprazole amoxicillin and clarithromycin
when amoxicillin combines with amiloride it decreases the effects of the action of drug by increasing gi absorption
amoxicillin and clavulanate potassium
when amoxicillin combines with amiloride it decreases the effects of the action of drug by increasing gi absorption
omeprazole amoxicillin and clarithromycin
when amoxicillin combines with amiloride, it decreases the effects of the action of the drug by increasing gi absorption
when amoxicillin combines with amiloride, it decreases the effects of the action of the drug by increasing gi absorption
may enhance the effects of the other by pharmacodynamic synergism
amiloride HCl is a potassium-conserving (antikaliuretic) medication with modest natriuretic, diuretic, and antihypertensive effect. amiloride, when combined with a thiazide or loop diuretic, has been proven to reduce the increased urine excretion of magnesium that occurs when a thiazide or loop diuretic is used alone. In patients receiving kaliuretic, diuretic medications, amiloride shows potassium-conserving action.
Frequency defined
Diarrhoea (3-8%)
Headache (3-8%)
Nausea (3-8%)
Vomiting (3-8%)
Hyperkalemia (10%)
Pain in the stomach(<3%)
Change in apetite (<3%)
Constipation (<3%)
Cough (<3%)
Dizziness (<3%)
Dyspnea (<3%)
Encephalopathy (<3%)
Laziness (<3%)
Anorexia (3-8%)
Cramps in muscles (<3%)
Weakness (<3%)
Impotence (<3%)
amiloride, like other potassium-conserving medications, can cause hyperkalemia (serum potassium levels greater than 5.5 mEq/L), which can be fatal if not treated.
Contraindication:
amiloride hypersensitivity
Hyperkalemia (K+ concentrations greater than 5.5 mEq/L [5.5 mmol/L])
Use in conjunction with a K+ sparing diuretic or K supplementation
Diabetes with impaired renal function (Scr >1.5 mg/dL [132.6 umol/L]
Pregnancy consideration:
US FDA pregnancy category: B
Lactation:
Studies show that amiloride is excreted in breast milk. Hence, depending on the need, either feeding should be stopped or administration of amiloride should be stopped
Pregnancy category:
Category A:Â Studies that were well-controlled and met expectations revealed no risk to the foetus `in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C:Â there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D:Â adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X:Â Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N:Â There is no data available for the drug under this category
Pharmacodynamics:
amiloride works by inhibiting sodium reabsorption at the distal convoluted tubule, cortical collecting tubule, and collecting duct, lowering the net negative potential of the tubular lumen and reducing potassium and hydrogen secretion and subsequent excretion. This mechanism accounts for a considerable portion of amiloride’s potassium sparing activity.
Pharmacokinetics:
Absorption
amiloride is readily absorbed into blood stream. Administration of amiloride win conjunction with food reduces its absorption
Distribution
23% of amiloride is protein bound. It attains a maximum bioavailability of 30 to 90%, reaching a peak plasma time in 3-4 hours
Metabolism
As it is not metabolized in the liver, there are no active metabolites
Elimination and excretion
About 50% of amiloride is excreted in urine and approximately 40% to 50% of it is eliminated through faeces.
Half-life: 6hours-9hours
Take this medication orally with food, generally once daily, as instructed by your doctor. If you take this medication at bedtime, you may need to get out of bed to urinate. This drug should be taken at least 4 hours before going to bed.
Generic Name: amiloride
Pronounced: a-MIL-oh-ride
Why do we use amiloride?
amiloride is employed in the treatment of  hypertension, heart failure, edema. amiloride also aids in the treatment or prevention of low blood potassium levels produced by other diuretics. Lowering blood pressure aids in the prevention of heart attacks, and kidney disorders. amiloride is a “water pill” (diuretic) that enables body to excrete excess fluids and salts while preventing the kidneys from excreting excessive potassium.
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