Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Dymelor
Synonyms :
acetohexamide
Class :
Antidiabetic agents
Brand Name :
Dymelor
Synonyms :
acetohexamide
Class :
Antidiabetic agents
Dosage forms and strengths Â
Oral TabletÂ
500 mg/tabÂ
Take 250 mg to 1500 mg twice daily
The maximum recommended dose is 1500 mg a day
Not indicatedÂ
Refer adult dosingÂ
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may increase the hypoglycemic effect of Sodium-Glucose Cotransporter 2 Inhibitors
may have an increased risk of hypoglycemia when combined with acetohexamide
may increase the therapeutic efficacy of each other when combined
may increase the risk of hypoglycemia when combined
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
meningococcal A C Y and W-135 diphtheria conjugate vaccine
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
may diminish the metabolism of each other when combined
the efficacy of acetohexamide can be increased with sulfisoxazole
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
it may diminish the metabolism when combined with formoterol
ximelagatran (investigational)Â
The combination of acetohexamide may lead to a reduced metabolism of ximelagatran
When medrysone is used in conjunction with acetohexamide, the risk or seriousness of hyperglycemia can rise
When used with levobetaxolol, acetohexamide's therapeutic effectiveness can be enhanced
Combining acetohexamide with pranlukast may cause a reduction in the acetohexamide metabolism
when used in combination with carbimazole, the therapeutic efficacy of acetohexamide can be decreased
the protein binding of acetohexamide may decrease when combined with isoxicam
acetohexamide: it may increase the risk of lidoflazine
acetohexamide: it may decrease the excretion rate of abacavir CNS depressant
acetohexamide: it may decrease the excretion rate of abacavir CNS depressant
acetohexamide: it may decrease the excretion rate of abacavir CNS depressant
acetohexamide: it may decrease the excretion rate of abacavir CNS depressant
acetohexamide: it may decrease the excretion rate of abacavir CNS depressant
the metabolism of acetohexamide can be lowered when combined with sulfinpyrazone
the protein binding of acetohexamide can be lowered when combined with sulindac
the coadministration of acetohexamide with prenylamine may lead to hypoglycemia
when combined with ivacaftor, there is a potential for an increased serum concentration of acetohexamide
acetohexamide: it may increase the risk of methemoglobinemia agents
acetohexamide: it may increase the risk of methemoglobinemia agents
acetohexamide: it may increase the risk of methemoglobinemia agents
acetohexamide: it may increase the risk of methemoglobinemia agents
acetohexamide: it may increase the risk of methemoglobinemia agents
acetohexamide: it may decrease the metabolism of piperazine
the risk or extent of hypoglycemia may increase when acetohexamide is combined with insulin aspart
the therapeutic efficacy of acetohexamide can be reduced when used in combination with chlorotrianisene
the efficacy of acetohexamide can be raised when used in combination with sulfametopyrazine
the potential or intensity of hyperglycemia can be heightened when flurandrenolide is combined with acetohexamide
When helometasone is used together with acetohexamide, this leads to elevated risk or seriousness of hyperglycemia
When acetohexamide is used together with diazoxide, this leads to reduction in therapeutic effectiveness of acetohexamide
methylprednisolone hemisuccinateÂ
When methylprednisolone hemisuccinate is aided with acetohexamide, this leads to elevated hyperglycemia risk
beta-Blockers may enhance the hypoglycemic effect of sulfonylureas
beta-Blockers may enhance the hypoglycemic effect of sulfonylureas
beta-Blockers may enhance the hypoglycemic effect of sulfonylureas
beta-Blockers may enhance the hypoglycemic effect of sulfonylureas
beta-Blockers may enhance the hypoglycemic effect of sulfonylureas
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may increase the hypoglycaemic effect
may enhance the serum concentration of CYP2C9 inhibitors
may increase the hypoglycemic effect of beta blockers
may enhance the hypoglycemic effect of beta blockers
may enhance the effect of sulfonylureas
may enhance the effect of sulfonylureas
may enhance the effect of sulfonylureas
may enhance the effect of sulfonylureas
may enhance the effect of sulfonylureas
It may intensify the hypoglycemic effect of sulfonylureas
It has the potential to amplify the hypoglycemic impact of sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
lansoprazole, amoxicillin, and clarithromycin
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
bismuth subcitrate, metronidazole and tetracycline
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
When acetohexamide is used together with abatacept, this lead to rise in acetohexamide’s metabolism
When acetohexamide is used together with golimumab, this lead to rise in acetohexamide’s metabolism
When acetohexamide is used together with infliximab, this lead to rise in acetohexamide’s metabolism
When acetohexamide is used together with ivosidenib, this lead to rise in acetohexamide’s metabolism
When acetohexamide is used together with adalimumab, this lead to rise in acetohexamide’s metabolism
When acetohexamide is used together with anakinra, this lead to rise in acetohexamide’s metabolism
When acetohexamide is used together with apremilast, this lead to rise in acetohexamide’s metabolism
When acetohexamide is used together with canakinumab, this lead to rise in acetohexamide’s metabolism
When acetohexamide is used together with etanercept, this lead to rise in acetohexamide’s metabolism
When acetohexamide is used together with adagrasib, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with agomelatine, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with amiodarone, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with amlodipine, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with amodiaquine, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with manidipine, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with armodafinil, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with asciminib, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with lovastatin, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with atovaquone, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with isavuconazole, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with avapritinib, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with bexarotene, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with leflunomide, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with bortezomib, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with cannabidiol, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with cerivastatin, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with chloramphenicol, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with clevidipine, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with clopidogrel, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with cyclizine, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with dapsone, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with delavirdine, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with diacerein, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with diosmin, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with dronabinol, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with efavirenz, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with eletriptan, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with enasidenib, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with ethambutol, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with etravirine, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with felbamate, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with felodipine, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with flecainide, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with floxuridine, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with fluorouracil, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with fluvastatin, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with hydromorphone, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with gemfibrozil, this lead to reduction in acetohexamide’s metabolism
When acetohexamide is used together with imatinib, this lead to reduction in acetohexamide’s metabolism
the protein binding efficiency of acetohexamide may be reduced
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
the therapeutic activity of acetohexamide may be decreased
when combined with ivacaftor, there is a potential for an increased serum concentration of acetohexamide
the therapeutic effect of acetohexamide may be reduced
the protein binding efficacy of acetohexamide may be reduced
the protein binding efficacy of acetohexamide may be reduced
the protein binding efficacy of acetohexamide may be reduced
the risk of hyperglycemia may be increased
the protein binding efficacy of acetohexamide may be reduced
the rate of metabolism of candesartan cilexetil may be reduced
the therapeutic activity of acetohexamide may be increased
the anti-diabetic efficacy of acetohexamide can be reduced with mometasone furoate
dipeptidyl peptidase-IV inhibitors increase the effect of hypoglycemia of sulfonylureas
dipeptidyl peptidase-IV inhibitors increase the effect of hypoglycemia of sulfonylureas
Actions and Spectrum:Â
Action:Â
Hypoglycemic Action: acetohexamide belongs to the class of drugs known as sulfonylureas. Its primary action is to stimulate insulin release from the beta cells of the pancreas. This results in increased blood insulin levels, which helps lower elevated blood sugar levels in people with type 2 diabetes. By enabling glucose to enter cells, it plays a crucial role in improving glucose utilization and ensuring that blood glucose levels remain within a balanced and optimal range.Â
Spectrum:Â
Type 2 Diabetes: acetohexamide is specifically indicated for the treatment of type 2 diabetes, which is a condition characterized by insulin resistance and impaired insulin secretion. It is not effective in the treatment of type 1 diabetes, as it relies on the presence of functioning pancreatic beta cells to stimulate insulin release.Â
Mild to Moderate Diabetes: acetohexamide is typically prescribed for individuals with mild to moderate type 2 diabetes. It may not be the first choice for individuals with severe diabetes or those who are unresponsive to other treatments.Â
Frequency not defined Â
Pale or yellowed skinÂ
Rapid weight gainÂ
Increased urinationÂ
ConfusionÂ
WeaknessÂ
FeverÂ
Dark colored urineÂ
SwellingÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity: acetohexamide should not be used if a person has a known hypersensitivity or allergy to the drug or its components.Â
Type 1 Diabetes: acetohexamide is not intended for treating type 1 diabetes, characterized by a lack of insulin production.Â
Severe Liver Disease: Individuals with severe liver impairment may have trouble metabolizing acetohexamide, which could increase the risk of adverse effects. It’s essential to exercise caution or avoid its use in such cases.Â
Severe Kidney Disease: The kidneys primarily excrete acetohexamide and its metabolites. In individuals with severe kidney disease, the drug can accumulate in the body and increase the risk of hypoglycemia. Dose adjustments or alternative medications may be necessary.Â
Pregnancy and Breastfeeding: The use of acetohexamide during pregnancy and breastfeeding should be carefully considered. It is typically not recommended during pregnancy because maintaining stable blood glucose levels is crucial for the health of both the mother and the developing fetus.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: Â
acetohexamide is an oral medication used to treat type 2 diabetes. It belongs to a class of drugs known as sulfonylureas, which work by stimulating the pancreas to release more insulin and increase the sensitivity of peripheral tissues to insulin.Â
Pharmacodynamics:Â Â
Stimulation of Insulin Release: acetohexamide mainly exerts its effects through the interaction with distinctive receptors located on the beta cells within the pancreas. This interaction initiates a cascade that leads to enhanced insulin secretion, a crucial hormone responsible for the regulation of blood sugar levels. Insulin plays a crucial role in promoting glucose absorption by peripheral tissues, such as muscle and adipose cells, leading to a decrease in blood glucose concentrations.Â
Enhanced Insulin Sensitivity: acetohexamide also enhances the sensitivity of target tissues to insulin, which means that the existing insulin is more effective at facilitating glucose uptake by cells. Â
Pharmacokinetics:Â
AbsorptionÂ
acetohexamide is well absorbed from the gastrointestinal tract after oral administration.Â
DistributionÂ
It is distributed throughout the body, including into tissues and cells, and can bind to plasma proteins.Â
MetabolismÂ
acetohexamide is metabolized in the liver, primarily via hepatic microsomal enzymes. Metabolism can lead to the formation of active and inactive metabolites.Â
Excretion and EliminationÂ
The drug, along with its metabolites, is mainly eliminated through urinary excretion.Â
Administration: Â
Typically, acetohexamide is taken once daily, usually in the morning. Â
Follow your healthcare provider’s instructions regarding when to take it.Â
The dosage of acetohexamide will vary depending on your individual medical condition and response to the medication. Â
Your healthcare provider will determine the appropriate starting dose for you.Â
Patient information leafletÂ
Generic Name: acetohexamideÂ
Why do we use acetohexamide? Â
acetohexamide functions by promoting the pancreas to increase its insulin production, thereby enhancing the body’s ability to efficiently utilize glucose. Consequently, this medication can contribute to enhanced management of blood sugar levels in individuals living with type 2 diabetes. Â
acetohexamide has the potential to alleviate typical diabetes symptoms, including increased thirst, frequent urination, and fatigue, through its regulation of blood sugar levels. Â
acetohexamide may be employed as alone treatment or in conjunction with other antidiabetic drugs or insulin to attain ideal glycemic management in individuals diagnosed with type 2 diabetes.Â
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