Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Previscan
Synonyms :
fluindione
Class :
Anticoagulant, Indanedione
Brand Name :
Previscan
Synonyms :
fluindione
Class :
Anticoagulant, Indanedione
Dosage Forms & StrengthsÂ
TabletÂ
20 mgÂ
It is indicated for preventing the risk of thrombosis and embolism, such as venous thromboembolism, pulmonary embolism, and cerebral embolism in patients with acute illness or at risk of thromboembolic complications
The usual adult dose will be 20 mg oral once daily, adjusted after monitoring coagulation
Dose Adjustments
Renal Dose Adjustments>
In case of renal impairment, if CrCL is below 20 mL/min, fluindione is not recommended, and it is recommended to stop the treatment if renal impairment is observed
Safety and efficacy are not seen in pediatricsÂ
Refer to the adult dosingÂ
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may increase the metabolism of vitamin K antagonists
may increase the metabolism of vitamin K antagonists
may increase the metabolism of vitamin K antagonists
may increase the metabolism of vitamin K antagonists
may increase the metabolism of vitamin K antagonists
may increase the anti-coagulant effect of androgens
may increase the anti-coagulant effect of salicylates
may enhance the anticoagulant effect of fibric acid derivatives
may increase the anti-coaugulant effect of salicylates
may increase the anti-coagulant effect of nonsteroidal anti-inflammatory agents
may increase the CNS depressant effect of CNS depressants
they may diminish the serum concentration when combined with vitamin k antagonists
may enhance the serum concentration when combined with Vitamin K Antagonists
estrogens esterified/methyltestosterone            Â
may increase the anticoagulant effect of Androgens
may enhance the serum concentration of Antacids
aluminum hydroxide/magnesium carbonateÂ
may enhance the serum concentration of aluminum hydroxide
It may enhance the serum concentration when combined with miconazole (topical)
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
lansoprazole, amoxicillin, and clarithromycin
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
pentamycin increases the therapeutic efficacy of fluindione when used in combination
allopurinol increases the effect of anticoagulation of vitamin K antagonists
may increase the anticoagulant effect of each other when combined
Selective Serotonin Reuptake Inhibitors may enhance the anticoagulant effect of Vitamin K
Selective Serotonin Reuptake Inhibitors may enhance the anticoagulant effect of Vitamin K
Selective Serotonin Reuptake Inhibitors may enhance the anticoagulant effect of Vitamin K
Selective Serotonin Reuptake Inhibitors may enhance the anticoagulant effect of Vitamin K
Selective Serotonin Reuptake Inhibitors may enhance the anticoagulant effect of Vitamin K
may increase the anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
It may enhance the serum concentration when combined with CYP2C9 Inhibitors
It may enhance the serum concentration when combined with CYP2C9 Inhibitors
thyroid products increase the effect of anticoagulation of vitamin K antagonists
thyroid products increase the effect of anticoagulation of vitamin K antagonists
thyroid products increase the effect of anticoagulation of vitamin K antagonists
thyroid products increase the effect of anticoagulation of vitamin K antagonists
it may diminish the excretion rate when combined with antibiotics, resulting in an enhanced serum level
Vitamin K antagonists: they may increase the antiplatelet effect of antiplatelet agents
Vitamin K antagonists: they may increase the antiplatelet effect of antiplatelet agents
Vitamin K antagonists: they may increase the antiplatelet effect of antiplatelet agents
Vitamin K antagonists: they may increase the antiplatelet effect of antiplatelet agents
Vitamin K antagonists: they may increase the antiplatelet effect of antiplatelet agents
When fluindione is used together with sertraline, the risk or seriousness of bleeding may be enhanced
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
When fluindione is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
fluindione metabolism is increased when used in combination with abatacept
when aceclofenac is combined with fluindione, there is an increased risk of bleeding
adverse effects of the combination of fluindione and zotepine are increased when used
the efficacy of fluindione is reduced when ubidecarenone is used in combination
anticoagulant properties or actions of fluindione are increased with tolbutamide
anticoagulant properties or actions of fluindione are increased with ampicillin
when combined with fluindione, there is an increased risk of bleeding
When fluindione is used together with ridaforolimus, this leads to enhanced concentration serum of fluindione
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the metabolism of Vitamin K Antagonists
may increase the metabolism of Vitamin K Antagonists
may increase the metabolism of Vitamin K Antagonists
may increase the metabolism of Vitamin K Antagonists
may increase the metabolism of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
may enhance the anticoagulant effect of Vitamin K Antagonists
choline magnesium trisalicylate
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
vitamin K1 (phytonadione)Â may reduce the anticoagulant effect of vitamin K antagonists
cephalosporins may enhance the anticoagulant effect of vitamin K antagonistsÂ
cephalosporins may enhance the anticoagulant effect of vitamin K antagonistsÂ
cephalosporins may enhance the anticoagulant effect of vitamin K antagonistsÂ
metformin reduces the effect of anticoagulation of vitamin K antagonists
may increase the anticoagulant effect
may increase the anti-coagulant action of anti-coagulants
may increase the anticoagulant effect
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may decrease the anticoagulant effect of direct-acting viral agents
may decrease the anticoagulant effect of direct-acting antiviral agents
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
relugolix/​estradiol/​norethindrone
may increase the anticoagulant effect
relugolix/estradiol/norethindrone
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect of vitamin K antagonists
may increase the levels of serum concentration of vitamin K antagonists
may increase the levels of serum concentration of vitamin K antagonists
may increase the levels of serum concentration of vitamin K antagonists
may increase the levels of serum concentration of vitamin K antagonists
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
May decrease the serum concentration
May decrease the serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the anticoagulant effect
amoxicillin and clavulanate potassium
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
bismuth subcitrate, metronidazole and tetracycline
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
may have an increased anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect of HMG-CoA Reductase Inhibitors
drospirenone/ethinyl estradiol/levomefolateÂ
may enhance the serum concentration of Hormonal Contraceptives
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may decrease the anticoagulant effect of Vitamin K Antagonists
5-Aminosalicylic Acid Derivatives: they may increase the anticoagulant effect of Vitamin K Antagonists
5-Aminosalicylic Acid Derivatives: they may increase the anticoagulant effect of Vitamin K Antagonists
may decrease the anticoagulant effect of Direct Acting Antiviral Agents
may enhance the serum concentration of Hormonal Contraceptives
etonogestrel/ethinyl estradiolÂ
may increase the serum concentration of Hormonal Contraceptives
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
oxaceprol decreases the effect of vitamin K antagonists
It may enhance the risk of adverse effects when combined with Peptide Hormones
may increase the anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
meningococcal A C Y and W-135 diphtheria conjugate vaccine
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
relugolix/​estradiol/​norethindrone
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
relugolix/estradiol/norethindrone
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
Actions and Spectrum:Â
Actions:Â
fluindione is an anticoagulant that comes under the anti-vitamin K group, which prevents vitamin K action. It has a role in blood clotting. fluindione will slow blood clotting and prevent clots from forming in arteries and veins.Â
Spectrum:Â
The spectrum of fluindione is used as an anticoagulant in conditions such as phlebitis, pulmonary embolism, atrial fibrillations, and acute myocardial infarctions, and it can be a recommended alternative to heparin therapy.Â
Frequency Not Defined Â
HematomasÂ
Bleeding from nose, gumsÂ
Blood in urineÂ
Blood in stoolÂ
Bloody spittingÂ
FatigueÂ
BreathlessnessÂ
HeadacheÂ
Discomfort unexplainedÂ
FeverÂ
Respiratory discomfortÂ
DiarrhoeaÂ
Joint painÂ
alopeciaÂ
Black Box Warning:Â
Before initiating the treatment, the patient’s cognitive functions to psychological and social behavior are observed due to therapy constraints.Â
Contraindication/Caution:Â
ContraindicationsÂ
CautionsÂ
Pregnancy consideration:Â Â
No data is available regarding the administration of the drug during pregnancy.Â
Breastfeeding warnings:Â Â
No data is available regarding the excretion of drug in breast milk.Â
Pregnancy category:Â
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.   Â
Category N: No data is available for the drug under this category.Â
Pharmacology:Â
fluindione is an anticoagulant that comes under the anti-vitamin K group, which prevents vitamin K action and has a role in blood clotting. fluindione will slow the blood clotting and prevent the clots that form or form in arteries and veins. AVKs show an indirect anticoagulant effect, which prevents the synthesis of active forms for several coagulation factors.Â
Pharmacodynamics:Â
VKA interferes with the mechanism of vitamin K inhibition, which is a cofactor of carboxylase enzyme used to convert glutamic acid and form gamma carboxyglutamic acid along with coagulation factors such as II, VII, IX, and X and inhibitors such as C and S proteins necessary for attachment to phospholipid surface which catalyze reactions in which they are involved. Fluindione has a long half-life.Â
Pharmacokinetics:Â
AbsorptionÂ
hypoprothrombinemia within 72 hours after the drug administration.Â
DistributionÂ
Not availableÂ
MetabolismÂ
Metabolism in hepatic cells. Â
Elimination and ExcretionÂ
The half-life is 6 hours to 2 or 3 daysÂ
Administration:Â
fluindione oral administration in which it should be swallowed with a glass of water, and it should be taken once a day, preferably in the evening, as we can change the dose ASAP after the results of INR.Â
Patient information leafletÂ
Generic Name: fluindioneÂ
Pronounced: FLOO-in-dee-ownÂ
Why do we use fluindione?Â
fluindione is an anticoagulant that comes under the anti-vitamin K group, which prevents vitamin K action and has a role in blood clotting. fluindione will slow the blood clotting and prevent the clots that form or form in arteries and veins.Â
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