Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Adlarity
Synonyms :
Class :
Acetylcholinesterase Inhibitors
Brand Name :
Adlarity
Synonyms :
Class :
Acetylcholinesterase Inhibitors
Dosage Forms & Strengths
Transdermal
5mg
10mg
apply a 5 mg patch once in a week; and increase up to 10 mg patch once a week after 4-6 weeks
apply a 5 mg patch once in a week; and increase up to 10 mg patch once a week after 4-6 weeks
Safety and efficacy not established
may have an increased constipating effect when combined with clozapine
may have an increased anticholinergic effect when combined with glycopyrrolate
may diminish the serum concentration when combined
zolpidem: they may decrease the therapeutic effect of anticholinesterases
they increase the toxicity of opioid agonists
they increase the toxicity of opioid agonists
they increase the toxicity of opioid agonists
they increase the toxicity of opioid agonists
may increase the bradycardia effect
may decrease the therapeutic effects
may have an increased anticholinergic effect when combined with cimetropium
may have an increased constipating effect when combined with eluxadoline
may have an increased anticholinergic effect when combined with anticholinergic agents
it increases the concentration of CYP3A4 substrates in the serum
it increases the concentration of CYP3A4 substrates in the serum
may increase the anticholinergic effect of Anticholinergic Agents
anticholinergic agents increase the ulcer-producing effect of potassium citrate
may increase the anticholinergic effect of each other when combined
may have an increased anticholinergic effect when combined with anticholinergic agents
levosalbutamol: they may decrease the therapeutic effect of anticholinesterases
oxatomide: they may increase the anticholinesterase effect of anticholinesterases
may enhance the rate of excretion resulting in the lower serum level
may enhance the rate of excretion resulting in the lower serum level
may enhance the rate of excretion resulting in the lower serum level
may enhance the rate of excretion resulting in the lower serum level
may enhance the rate of excretion resulting in the lower serum level
it may reduce the therapeutic effect of anticholinergic agents
it may reduce the therapeutic effect of anticholinergic agents
it may reduce the therapeutic effect of anticholinergic agents
it may reduce the therapeutic effect of anticholinergic agents
it may reduce the therapeutic effect of anticholinergic agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
It may increase the neurotoxic effect of Antipsychotic Agents
it may increase the bradycardic effect of Beta-Blockers
it may increase the bradycardic effect of Beta-Blockers
it may increase the bradycardic effect of Beta-Blockers
it may increase the bradycardic effect on other Bradycardia-Causing Agents
it may enhance the risk of adverse effects of Cholinergic Agonists
it may enhance the risk of adverse effects of Cholinergic Agonists
it may enhance the risk of adverse effects of Cholinergic Agonists
it may enhance the risk of adverse effects of Cholinergic Agonists
it may enhance the risk of adverse effects of Cholinergic Agonists
it may enhance the risk of adverse effects of Acetylcholinesterase Inhibitors
it may enhance the risk of adverse effects of Acetylcholinesterase Inhibitors
it may enhance the risk of adverse effects of Acetylcholinesterase Inhibitors
it may enhance the risk of adverse effects of Acetylcholinesterase Inhibitors
it may enhance the risk of adverse effects of Acetylcholinesterase Inhibitors
it may reduce the neuromuscular blocking effect of Neuromuscular Blocking Agents
it may reduce the neuromuscular blocking effect of Neuromuscular Blocking Agents
it may reduce the neuromuscular blocking effect of Neuromuscular Blocking Agents
it may reduce the neuromuscular blocking effect of Neuromuscular Blocking Agents
it may reduce the neuromuscular blocking effect of Neuromuscular Blocking Agents
acetylcholinesterase Inhibitors reduce the therapeutic effect of anticholinergic Agents
acetylcholinesterase Inhibitors reduce the therapeutic effect of anticholinergic Agents
acetylcholinesterase Inhibitors reduce the therapeutic effect of anticholinergic Agents
acetylcholinesterase Inhibitors reduce the therapeutic effect of anticholinergic Agents
acetylcholinesterase Inhibitors reduce the therapeutic effect of anticholinergic Agents
acetylcholinesterase inhibitors may enhance the adverse/toxic effect of cholinergic Agonists
acetylcholinesterase inhibitors may enhance the adverse/toxic effect of cholinergic Agonists
acetylcholinesterase inhibitors may enhance the adverse/toxic effect of cholinergic Agonists
acetylcholinesterase inhibitors may enhance the adverse/toxic effect of cholinergic Agonists
acetylcholinesterase inhibitors may enhance the adverse/toxic effect of cholinergic Agonists
acetylcholinesterase Inhibitors May enhance the bradycardic effect of beta-Blockers
acetylcholinesterase Inhibitors May enhance the bradycardic effect of beta-Blockers
acetylcholinesterase Inhibitors May enhance the bradycardic effect of beta-Blockers
acetylcholinesterase Inhibitors May enhance the bradycardic effect of beta-Blockers
acetylcholinesterase Inhibitors May enhance the bradycardic effect of beta-Blockers
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
corticosteroids may enhance the adverse/toxic effect of acetylcholinesterase Inhibitors
corticosteroids may enhance the adverse/toxic effect of acetylcholinesterase Inhibitors
corticosteroids may enhance the adverse/toxic effect of acetylcholinesterase Inhibitors
corticosteroids may enhance the adverse/toxic effect of acetylcholinesterase Inhibitors
corticosteroids may enhance the adverse/toxic effect of acetylcholinesterase Inhibitors
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may enhance the neurotoxic (central) effect of antipsychotic agents
may increase the bradycardic effect of beta-blockers
may increase the bradycardic effect of beta-blockers
may increase the bradycardic effect of beta-blockers
may increase the bradycardic effect of beta-blockers
may increase the bradycardic effect of beta-blockers
may reduce the effect of neuromuscular-blocking agents
may reduce the effect of neuromuscular-blocking agents
may reduce the effect of neuromuscular-blocking agents
may reduce the effect of neuromuscular-blocking agents
may reduce the effect of neuromuscular-blocking agents
may decrease the levels of serum concentration of hormonal contraceptives
may decrease the levels of serum concentration of hormonal contraceptives
may decrease the levels of serum concentration of hormonal contraceptives
may decrease the levels of serum concentration of hormonal contraceptives
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may enhance the neurotoxic effect of antipsychotic agents
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of beta-blockers
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
may increase the effect of antipsychotic agents
reduce the therapeutic effect
reduce the therapeutic effect
reduce the therapeutic effect
reduce the therapeutic effect
reduce the therapeutic effect
may increase the neurotoxic effect
may increase the neurotoxic effect
may increase the neurotoxic effect
may increase the neurotoxic effect
may increase the neurotoxic effect
may increase the bradycardic effect
may increase the bradycardic effect
may increase the bradycardic effect
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
they decrease the efficacy of gastrointestinal agents
they decrease the efficacy of gastrointestinal agents
they decrease the efficacy of gastrointestinal agents
they decrease the efficacy of gastrointestinal agents
they decrease the efficacy of gastrointestinal agents
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may have an increasingly adverse effect when combined with other anticholinergic agents
may have an increasingly adverse effect when combined with other anticholinergic agents
may have an increasingly adverse effect when combined with other anticholinergic agents
may have an increasingly adverse effect when combined with other anticholinergic agents
may have an increasingly adverse effect when combined with other anticholinergic agents
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
may reduce the levels of serum concentration
spironolactone and hydrochlorothiazide
it increases the concentration of thiazide and its diuretics in the serum
it increases the concentration of thiazide and its diuretics in the serum
it increases the concentration of thiazide and its diuretics in the serum
it increases the concentration of thiazide and its diuretics in the serum
it increases the concentration of thiazide and its diuretics in the serum
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the therapeutic effect when combined with anticholinergic agents
may decrease the therapeutic effect when combined with anticholinergic agents
may have an increased tachycardic effect when combined with cannabinoid products
may have an increased tachycardic effect when combined with cannabinoid products
may have an increasingly adverse effect when combined with opioid agonists
may have an increasingly adverse effect when combined with opioid agonists
may have an increasingly adverse effect when combined with opioid agonists
may have an increasingly adverse effect when combined with opioid agonists
anticholinestereses: they may increase the toxic effect of mu-opioid receptor agonists
anticholinestereses: they may increase the toxic effect of mu-opioid receptor agonists
may have an increasingly adverse effect when combined with other anticholinergic agents
may decrease the therapeutic effect when combined with gastrointestinal agents
may decrease the therapeutic effect when combined with gastrointestinal agents
may have an increasingly adverse effect when combined with opioid agonists
may have an increasingly adverse effect when combined with opioid agonists
may have an increasingly adverse effect when combined with opioid agonists
may have an increasingly adverse effect when combined with opioid agonists
may have an increasingly adverse effect when combined with opioid agonists
may enhance the concentration of serum when combined with thiazide diuretics
may enhance the concentration of serum when combined with thiazide diuretics
may have a decreased therapeutic effect when combined with anticholinergic agents
may decrease the therapeutic effect when combined with gastrointestinal agents
may decrease the therapeutic effect when combined with gastrointestinal agents
amoxicillin/omeprazole/rifabutin
may decrease the therapeutic effect when combined with gastrointestinal agents
may decrease the therapeutic effect when combined with gastrointestinal agents
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may enhance the CNS depressant effect
may reduce the therapeutic effect of anticholinergic agents
may reduce the therapeutic effect of anticholinergic agents
may reduce the therapeutic effect of anticholinergic agents
may reduce the therapeutic effect of anticholinergic agents
may reduce the therapeutic effect of anticholinergic agents
hydrocodone/chlorpheniramine/pseudoephedrine
may decrease the therapeutic effect of anticholinergic agents
may decrease the therapeutic effect
may increase the immunosuppressive effect of corticosteroids
may increase the toxic effect
may decrease the level of serum concentration of pretomanid
may decrease the level of serum concentration of pretomanid
may diminish the therapeutic effect of acetylcholinesterase Inhibitors
may diminish the therapeutic effect of acetylcholinesterase Inhibitors
may diminish the therapeutic effect of acetylcholinesterase Inhibitors
may diminish the therapeutic effect of acetylcholinesterase Inhibitors
may diminish the therapeutic effect of acetylcholinesterase Inhibitors
may decrease the therapeutic effect of dipyradimole
may increase the adverse effect of corticosteroids
may increase the toxic effect of corticosteroids
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may increase the bradycardic effect of beta blockers
may decrease the therapeutic effect of anticholinergic agents
acrivastine and pseudoephedrine
may decrease the therapeutic effect of anticholinergic agents
may decrease the therapeutic effect when combined with anticholinergic agents
may decrease the therapeutic effect when combined with anticholinergic agents
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may enhance the risk of adverse effect of acetylcholinesterase inhibitors
may have an increased anticholinergic effect when combined with anticholinergic agents
may enhance the anticholinergic effect of Anticholinergic agents
may increase the anticholinergic effect of anticholinergic agents
may increase the toxic effect of other Anticholinergic Agents
may diminish the absorption when combined with nitroglycerin
may have an increasingly adverse effect when combined with glucagon
anticholinergic agents increase the toxicity of topiramate
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may decrease the levels of serum concentration
may increases the adverse effect of Opioid Agonists
buprenorphine,long-acting injection
may increases the adverse effect of Opioid Agonists.
acetaminophen/doxylamine/dextromethorphan
may increase the adverse effect of other Anticholinergic Agents
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the adverse/toxic effect
may enhance the risk of adverse effect
may enhance the risk of adverse effect
may enhance the risk of adverse effect
may enhance the risk of adverse effect
may enhance the risk of adverse effect
may have an increasingly adverse effect when combined with other anticholinergic agents
may have an increasingly adverse effect when combined with other anticholinergic agents
may have an increasingly adverse effect when combined with other anticholinergic agents
may have an increasingly adverse effect when combined with other anticholinergic agents
may have an increasingly adverse effect when combined with other anticholinergic agents
may diminish the therapeutic effect of Acetylcholinesterase Inhibitors
may decrease the therapeutic effect of Acetylcholinesterase Inhibitors
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
may decrease the therapeutic effect when combined with anticholinergic agents
may have an increasingly adverse effect when combined with other anticholinergic agents
may have an increased tachycardic effect when combined with cannabinoid products
may have an increased tachycardic effect when combined with cannabinoid products
may enhance the serum concentration of anticholinergic agents
may enhance the serum concentration of anticholinergic agents
may increase the efficacy of each other when combined
inducing agents of the cytochrome P450 enzymes, such as rifampin and carbamazepine, can reduce the exposure and effectiveness of rimonabant
may enhance the risk of hypertension when combined
may enhance the risk of hypertension when combined
may enhance the risk of hypertension when combined
may enhance the risk of hypertension when combined
may enhance the risk of hypertension when combined
an increase in rate of metabolism may be seen
the anticholinergic effect of chlorprothixene may be enhanced by anticholinergic agents
may decrease the level of serum concentration
may decrease the level of serum concentration
may decrease the level of serum concentration
may decrease the level of serum concentration
tenofovir disoproxil fumarate or tenofovir DF
may decrease the level of serum concentration
may decrease the level of serum concentration
may decrease the level of serum concentration
anticholinergic agents decrease the efficacy of secretin
Adverse drug reactions:
Frequency Defined
>10%
Erythema
Papules
Headache
1-10%
Muscle spasms
Insomnia
Abdominal pain
Application site dermatitis
Diarrhea
Application site pain
Dizziness
Abnormal dreams
Skin laceration
<1%
Edema
Post marketing Reports:
Hemolytic anemia
Heart block
QTc prolongation
Abdominal pain
Cholecystitis
Hepatitis
pancreatitis
Hyponatremia
Pregnancy warnings:
US FDA Pregnancy Category: N/A
Breastfeeding warnings:
crosses into breast milk- Unknown
Pregnancy Categories:
Patient Information Leaflet
Generic Name: donepezil transdermal
Why do we use donepezil transdermal?
donepezil transdermal belongs to the class of Acetylcholinesterase Inhibitors, which helps to treat Alzheimer’s disease and Dementia
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