diphenoxylate/atropine

Brand Name :

Lomotil

(United States) [Available]
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Synonyms :

diphenoxylate/atropine

Class :

Gastrointestinal agents; Antidiarrheal drugs; Antimotility agents

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Actions and Spectrum: 

diphenoxylate/atropine is a combination medication used to treat diarrhea. It works by slowing down the movement of the intestines, which reduces the frequency and urgency of bowel movements and helps to relieve diarrhea symptoms. The medication contains two active ingredients: diphenoxylate and atropine. 

diphenoxylate is an opioid agonist that acts on the mu-opioid receptors in the gastrointestinal tract. It works by slowing down the motility of the intestines, reducing the amount of fluid and electrolytes lost through the bowel movements, and improving the consistency of stools. diphenoxylate is structurally like the narcotic pain medication meperidine (Demerol) but has a much lower potential for abuse. 

atropine is added to the formulation to discourage misuse of diphenoxylate, as it can cause unpleasant side effects such as dry mouth, blurred vision, and urinary retention. Atropine also has some antidiarrheal effects on its own, as it reduces intestinal motility and secretions and can help to relieve cramps and spasms. 

The combination of diphenoxylate and atropine has a broad spectrum of activity against different types of diarrhea, including acute and chronic diarrhea caused by infectious, inflammatory, or functional disorders. However, it is not recommended for use in patients with bacterial infections or other specific causes of diarrhea, as it may interfere with the elimination of the infectious agent and delay the resolution of the infection. 

DRUG INTERACTION

diphenoxylate/atropine

&

  • Pembrolizumab / Berahyaluronidase
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  • typhoid polysaccharide vaccine
  • sodium phosphate
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  • cromolyn sodium, intranasal
  • red blood cells(Blood component)
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  • amino acids and electrolytes in dextrose with calcium
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  • rubidium Rb-82
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  • sodium sulfate, magnesium sulfate and potassium sulfate
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  • betiatide
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  • zilucoplan
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  • melitracen
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  • threonine
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  • pine bark extract
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  • niclosamide
  • pyrvinium
  • pipenzolate methylbromide/phenobarbitone
  • piracetam/ginkgo biloba/vinpocetine
  • benzyl benzoate/disulfiram
  • benzyl benzoate
  • loperamide/simethicone
  • piroctone olamine
  • sodium fusidate
  • piroxicam topical/capsaicin/menthol/methyl salicylate
  • sodium metabisulfite
  • sodium lauryl sulfate
  • taspoglutide
  • glyclopyramide
  • tolnaftate, gentamicin, iodochlorohydroxyquinoline, chlorocresol, betamethasone valerate
  • serratiopeptidase
  • sodium antimony gluconate
  • triamterene / benzthiazide
  • tribenoside / lidocaine
  • triclocarban
  • triprolidine/dextromethorphan  
  • vitamins/minerals/omega-3 Fatty acids
  • soyabean oil
  • sucralfate/oxethazaine
  • sucralfate/tinidazole/povidone iodine
  • sodium cromoglycate
  • aloe vera/liquid paraffin/white soft paraffin
  • aloe vera/jojoba oil/vitamin E
  • allantoin/triclosan/vitamin e/zinc oxide
  • alpha-Lipoic acid/minerals/multivitamins
  • alprazolam/paracetamol
  • alprazolam/melatonin
  • azithromycin/ambroxol
  • atorvastatin/clopidogrel/aspirin
  • aceclofenac, paracetamol and serratiopeptidase
  • alfacalcidol, vitamin B-complex, minerals and antioxidants
  • alpha- lipoic acid, vitamin b complex and vitamin c
  • alpha-galactosidase and simethicone
  • alpha-galactosidase, amylase, proteases, lipase and lactase
  • amikacin and cefepime
  • aminophylline, ephedrine and phenobarbitone
  • artesunate, sulphadoxine and pyrimethamine
  • finasteride/tamsulosin
  • flavoxate/ofloxacin
  • fenofibrate/metformin
  • lignocaine, hydrocortisone topical and allantoin
  • linoleic acid and sodium lactate
  • troxerutin
  • meclizine/nicotinic acid
  • mecobalamin/ginkgo Biloba
  • spirulina
  • loperamide and furazolidone
  • ketoconazole/cetrimide
  • ketoconazole/zinc pyrithione
  • lercanidipine/atenolol
  • levocetirizine/montelukast/ambroxol
  • levarterenol
  • levocetirizine/phenylpropanolamine 
  • indapamide/amlodipine
  • itopride/methyl polysiloxane
  • mebendazole/levamisole
  • eberconazole/mometasone
  • gliclazide/metformin/pioglitazone
  • fluconazole/tinidazole
  • haemocoagulase
  • halometasone
  • hesperidin
  • imipramine/chlordiazepoxide
  • idebenone / l-arginine / zinc sulphate/selenium/proanthocyanidin
  • mecobalamin and piracetam
  • mesterolone
  • mosapride and pantoprazole
  • atorvastatin, co enzyme q10, vitamin e, zinc, and selenium
  • azithromycin and benzalkonium chloride
  • beta carotene, vitamin c, vitamin e, minerals, lutein, eicosapentaenoic acid, docosahexenoic acid and vit b12
  • alpha-galactosidase
  • aloe vera gel/vitamin e/lactic acid
  • aloe vera gel/jojoba/vitamin e/glycerine
  • famotidine and domperidone
  • faropenem medoxomil
  • nedosiran
  • fluconazole/ornidazole/azithromycin
  • ebastine/montelukast
  • eberconazole
  • dienogest/estradiol valerate
  • ambroxol/salbutamol
  • benzoic acid/salicylic acid/ichthammol/ triamcinolone acetonide
  • desloratadine/ambroxol
  • dexibuprofen/paracetamol
  • atorvastatin/ramipril
  • diastase
  • diastase and simethicone
  • diazepam and propranolol
  • dexrabeprazole / domperidone
  • dexrabeprazole
  • dexketoprofen /paracetamol
  • beta carotene/vitamin C/minerals
  • aloe vera gel/urea
  • aloe vera gel/glycerine
  • alpha-lipoic acid/benfotiamine/chromium/folic acid/mecobalamin / vit b6
  • alprazolam/propranolol
  • alprazolam /sertraline
  • ibuprofen/dextropropoxyphene
  • ambroxol/cetirizine/phenylephrine/ guaiphenesin/menthol
  • dextropropoxyphene/dexchlorpheniramine maleate/bromhexine
  • promegestone
  • batroxobin
  • bencyclane
  • benfluorex
  • acetylpheneturide
  • abarelix
  • abetimus
  • naftidrofuryl
  • nalorphine
  • oxiracetam
  • letosteine
  • lafutidine
  • leuprorelin
  • levodropropizine
  • glutaral
  • losartan/ramipril
  • gallopamil
  • lanatoside c
  • lauromacrogol
  • gestodene
  • aceclofenac/methyl salicylate/menthol/linseed oil/capsaicin
  • aceclofenac/paracetamol/tizanidine
  • alginic acid/magaldrate/simethicone
  • aceclofenac/paracetamol
  • aceclofenac/rabeprazole
  • alginic acid
  • pantoprazole and domperidone
  • urokinase
  • rimiterol
  • olanzapine/fluoxetine
  • normethadone/hydroxyephedrine
  • myrtol
  • moxonidine
  • propylhexedrine
  • sodium hypochlorite solution
  • sodium chloride/sodium citrate
  • Hepatitis B Vaccine (Recombinant [Adjuvanted])
  • Hepatitis B Vaccine (Recombinant)
  • aceclofenac and serratiopeptidase
  • levosulpiride
  • niaprazine
  • tromantadine
  • trimetazidine
  • vinburnine
  • mizoribine
  • molgramostim
  • mosapride
  • eugenol
  • tolperisone
  • etamsylate
  • etynodiol
  • mizolastine
  • metenolone
  • reproterol
  • rebamipide
  • mephenoxalone
  • metandienone
  • furosemide/spironolactone
  • hydroxycarbamide
  • tenonitrozole
  • fenoverine
  • fenquizone
  • tiapride
  • tibolone
  • furazolidone
  • furosemide & amiloride
  • fosfestrol
  • fluclorolone
  • flubendazole
  • tertatolol
  • tetracosactide
  • tetryzoline
  • tolciclate
  • trapidil
  • troxipide
  • temoporfin
  • telbivudine
  • teprenone
  • hexamidine
  • mebhydrolin
  • mepartricin
  • fencamfamin
  • medazepam
  • theodrenaline
  • thiamazole
  • thiocolchicoside
  • psilocybin
  • veralipride
  • pyritinol
  • opipramol
  • oprelvekin
  • betamethasone + gentamicin
  • betamethasone + neomycin
  • betamethasone + salicylic acid
  • oxedrine
  • bopindolol
  • orgotein (investigational)
  • oxaceprol
  • ormeloxifene
  • bevantolol
  • bifemelane
  • clebopride
  • demoxytocin
  • cicletanine
  • cefsulodin
  • chlortalidon
  • sisomicin
  • somatrem
  • carbazochrome
  • caroverine
  • cathine
  • ipriflavone
  • isepamicin
  • silymarin
  • simethicone
  • sermorelin
  • diloxanide
  • dimethindene
  • diosmin/hesperidin
  • calamine
  • canrenone
  • captodiame
  • imidapril
  • cefetamet
  • cefodizime
  • cefoperazone + sulbactam
  • ivermectin + albendazole
  • serrapeptase
  • bromisoval
  • beraprost
  • pridinol
  • proglumide
  • bamipine
  • barnidipine
  • bamifylline
  • benzbromarone
  • betamethasone/fusidic acid
  • para-chlorophenol
  • pantethine
  • nomifensine
  • pemoline
  • parnaparin
  • pentolinium
  • nialamide
  • novobiocin
  • nicergoline
  • octocrylene
  • octisalate
  • oftasceine
  • oxolamine
  • oxyphencyclimine
  • penfluridol
  • pentoxyverine
  • phenoxymethylpenicillin
  • picloxydine
  • pilsicainide hydrochloride
  • piperazine
  • pirarubicin
  • policresulen
  • prifinium bromide
  • prethcamide
  • pristinamycin
  • pirenzepine
  • piribedil
  • pimethixene
  • pargyline
  • phosphatidyl choline
  • phthalylsulfathiazole
  • phytomenadione
  • pranlukast
  • pinazepam
  • oxyphenonium
  • noxytiolin
  • periciazine
  • pethidine
  • phenindamine
  • histidine
  • isoleucine
  • proline
  • lauric acid
  • lymecycline
  • hypromellose
  • abiraterone acetate and niraparib
  • ichthammol
  • levamisole
  • naftazone
  • nefopam
  • oxprenolol
  • oxybuprocaine
  • elranatamab-bcmm
  • lapyrium
  • isoaminile
  • iotrolan
  • mazindol
  • masoprocol
  • lypressin
  • meradimate
  • molsidomine
  • monobenzone
  • mequinol/gluconolactone/ lactobionic acid/ arbutin
  • medifoxamine
  • mebutamate
  • metergoline
  • methantheline
  • methdilazine
  • metocurine
  • micronomicin
  • metaraminol
  • mephenesin
  • menadione
  • medrysone
  • metixene
  • levobetaxolol
  • guaiacol glycerol ether
  • eucalyptol
  • sodium tetradecyl sulfate
  • sugammadex
  • carbetocin
  • certoparin
  • chlorcyclizine/pseudoephedrine
  • cephapirin
  • indecainide
  • iobitridol
  • iomeprol
  • chlorphenesin
  • msud analog
  • msud maxamum
  • iceland moss
  • glutethimide
  • hexachlorophene
  • haloprogin
  • deferoxamine
  • ethchlorvynol
  • dexpanthenol topical
  • etilefrine
  • deslanoside
  • carbocromen
  • diazolidinylurea
  • dibenzepin
  • etofamide
  • guanoxan
  • halazepam
  • guanadrel sulfate
  • dapiprazole
  • soapwort
  • debrisoquine
  • l-tryptophan
  • chlormerodrin
  • chlorquinaldol
  • cetrimonium
  • carbocisteine
  • chlorcyclizine/codeine
  • technetium Tc-99m tetrofosmin
  • technetium Tc-99m disofenin
  • technetium Tc-99m gluceptate
  • technetium Tc-99m labeled red blood cells
  • amylmetacresol/dextromethorphan hydrobromide
  • anileridine phosphate
  • pyrethrins
  • pyrantel pamoate
  • quinagolide
  • spiramycin
  • standard hyperkalemic cardioplegia solution
  • technetium tc-99m mertiatide
  • technetium tc-99m medronate
  • bemotrizinol / bisoctrizole
  • benfotiamine
  • bemotrizinol + titanium dioxide + zinc oxide
  • technetium Tc-99m oxidronate
  • technetium Tc-99m pentetate
  • technetium Tc-99m pyrophosphate
  • benziodarone
  • octinoxate/bisoctrizole
  • bicisate dihydrochloride
  • technetium Tc-99m bicisate
  • norelgestromin/ethinyl estradiol
  • norgestimate/ethinyl estradiol
  • ximelagatran (investigational)
  • xamoterol
  • trioxsalen
  • poly-urea urethane
  • rilmenidine
  • pemirolast
  • oxitriptan
  • beclomethasone, intranasal
  • thimerosal
  • camphor gel
  • camphor
  • mumps virus vaccine, live
  • rubella virus vaccine, live
  • aluminum chloride (dental)
  • alum irrigation
  • framycetin, phenylephrine, and gramicidin
  • ombitasvir, paritaprevir, ritonavir, and dasabuvir
  • olipudase alfa
  • etonogestrel/ethinyl estradiol
  • mycophenolate
  • fluoroestradiol F 18
  • donor organ cardioplegia solution
  • fluciclovine F 18
  • fusidic acid (ophthalmic)
  • fusidic acid and hydrocortisone
  • framycetin, dexamethasone, and gramicidin
  • fludeoxyglucose F-18
  • fluorouracil/salicylic acid
  • indium In-111 oxyquinoline
  • indium In-111 pentetreotide
  • indium In-111 capromab pendetide
  • lusutrombopag
  • mitomycin (ophthalmic)
  • mifepristone and misoprostol
  • minoxidil (systemic)
  • methyl aminolevulinate (topical)
  • methyl folate, methylcobalamin, and acetylcysteine
  • ciclesonide/formoterol/tiotropium
  • nedocromil (Oral Inhalation)
  • batefenterol (Investigational)
  • neostigmine and glycopyrrolate
  • nepafenac ophthalmic
  • netupitant/palonosetron
  • meperidine and promethazine
  • mepivacaine and levonordefrin
  • maltodextrin
  • medical cannabis
  • medium chain triglycerides
  • mometasone/glycopyrrolate (glycopyrronium)/ indacaterol
  • moxifloxacin ophthalmic
  • neomycin/fluocinolone
  • nadroparin
  • iodine I-125 iothalamate
  • amikacin liposome (oral inhalation)
  • bupivacaine liposome
  • natamycin
  • lopinavir and ritonavir
  • lysine
  • macitentan and tadalafil
  • mitomycin pyelocalyceal
  • moclobemide
  • mometasone and indacaterol
  • efinaconazole
  • blue-green algae
  • indocyanine green
  • follitropin beta
  • lumasiran
  • glycerin/lidocaine
  • edrophonium/atropine
  • indigo carmine
  • lutropin alfa
  • instant glucose/intravenous dextrose
  • iobenguane I-123
  • ixekizumab
  • isosulfan blue dye
  • levofloxacin ophthalmic
  • levonorgestrel oral/ferrous bisglycinate/ ethinylestradiol
  • ethinyl estradiol/levonorgestrel transdermal
  • hydroquinone
  • hydroxypropyl methylcellulose
  • icodextrin
  • lipid emulsion (soybean, medium-chain triglyceride, olive, and fish oils; [SMOF])
  • iodinated I 125 albumin
  • iodinated I 131 albumin
  • lipid emulsion (plant oil-based)
  • levonorgestrel intrauterine
  • levonorgestrel/ethinyl estradiol
  • lactic acid and sodium-PCA
  • lactated Ringer solution
  • ketotifen (systemic)
  • lanolin
  • leuprolide and norethindrone
  • levodopa and benserazide
  • gonadorelin acetate
  • hemodialysis solutions
  • nirsevimab
  • gentian violet
  • gallium ga-68 dotatate
  • fusidic acid and betamethasone
  • gallium citrate Ga-67
  • gadopentetate dimeglumine
  • gadofosveset
  • follitropin delta
  • follitropin alfa and lutropin alfa
  • follitropin alfa
  • rocatinlimab
  • grass pollens allergen extract
  • flotufolastat F18
  • fluorescein ophthalmic
  • barium
  • balanced salt solution
  • air polymer type A intrauterine device
  • clodronate
  • bentoquatam
  • clobetasone
  • alfacalcidol
  • citric acid/glucono-delta-lactone/magnesium carbonate
  • benzoin
  • desirudin
  • immune globulin IV (IGIV)
  • dequalinium
  • pseudoephedrine/desloratadine
  • clofedanol
  • cyproterone and ethinyl estradiol
  • dextranomer and hyaluronic acid or derivatives
  • diatrizoate meglumine and diatrizoate sodium
  • glucosamine sulfate, chondroitin sulfate and Msm
  • squill
  • gotu kola
  • blessed thistle
  • bitter melon
  • apraclonidine
  • chlophedianol/dexbrompheniramine/pseudoephedrine
  • wild jujube
  • chitosan
  • cilazapril/hydrochlorothiazide
  • dexbrompheniramine and phenylephrine
  • diethylene triamine penta-acetic acid
  • dexchlorpheniramine and pseudoephedrine
  • lily of the valley
  • diflucortolone
  • corydalis
  • lemon balm
  • MSM
  • calcium polystyrene sulfonate
  • caprylidene
  • peppermint oil
  • efavirenz/lamivudine/tenofovir DF
  • emtricitabine/tenofovir DF /efavirenz
  • dutasteride/tamsulosin
  • milk thistle
  • centaury
  • horseweed
  • lycopus
  • agrimony
  • alfalfa
  • kava
  • cetrorelix
  • cetylpyridinium
  • chlophedianol and dexbrompheniramine
  • betahistine
  • choline C-11
  • boric acid vaginal suppository
  • aluminum acetate
  • aluminum chloride hexahydrate
  • 14-C urea breath test
  • absorbable collagen
  • valoctocogene roxaparvovec-rvox
  • amlodipine and celecoxib
  • aspirin and omeprazole
  • azilsartan and chlorthalidone
  • landiolol (Pending FDA approval)
  • isosorbide dinitrate/hydralazine
  • losartan/hydrochorothiazide
  • udenafil
  • dextromethorphan/quinidine
  • onasemnogene abeparvovec
  • orphenadrine/aspirin/caffeine
  • Trace elements
  • sodium phenylbutyrate/ taurursodiol
  • fish oil triglycerides
  • infant formula
  • glutamine
  • chloroquine phosphate
  • afatinib
  • quinidine gluconate
  • methylergonovine
  • prothrombin complex concentrate, human
  • BCG intravesical live
  • capivasertib
  • cedazuridine
  • carbonyl iron
  • iron dextran complex
  • lovotibeglogene autotemcel (FDA Approval Pending)
  • sodium benzoate/sodium phenylacetate
  • mineral oil otic
  • zolmitriptan transdermal
  • midazolam intranasal
  • fosinopril/hydrochlorothiazide
  • caplacizumab
  • arginine
  • sodium phenylbutyrate
  • meloxicam/rizatriptan
  • manganese
  • acetaminophen/pamabrom/pyridoxine
  • varicella zoster immune globulin, human
  • amitriptyline/perphenazine
  • narsoplimab (Pending FDA Approval)
  • amlodipine/perindopril
  • imiglucerase
  • canagliflozin/metformin
  • tafamidis meglumine
  • somatrogon-ghla
  • glimepiride/rosiglitazone
  • becaplermin
  • lithium
  • loxapine inhaled
  • nicotine transdermal
  • tixagevimab and cilgavimab (Investigational)
  • muromonab CD3
  • ansuvimab
  • coal tar bath products
  • fibrin sealant
  • arimoclomol (FDA Approval Pending)
  • varenicline intranasal
  • aducanumab
  • oxycodone/naloxone
  • ritlecitinib
  • sodium polystyrene sulfonate
  • calcipotriene/betamethasone
  • calcium hydroxylapatite
  • cantharidin topical
  • doxepin cream
  • clocortolone
  • formaldehyde topical
  • sodium sulfide topical
  • collagenase
  • selegiline transdermal
  • foscarbidopa/foslevodopa (FDA approval pending)
  • saxagliptin/metformin
  • linagliptin/metformin
  • linzagolix (FDA approval pending)
  • efgartigimod/hyaluronidase SC
  • Elamipretide
  • rozanolixizumab
  • diazoxide
  • glimepiride/pioglitazone
  • cipaglucosidase alfa
  • dihydroergotamine intranasal
  • delandistrogene moxeparvovec
  • beremagene geperpavec
  • hyaluronic acid and derivatives
  • hyaluronic acid, non-animal stabilized
  • eplontersen (FDA Approval Pending)
  • nitric oxide gas
  • sodium phenylbutyrate and taurursodiol
  • treprostinil SC
  • viltolarsen
  • albuterol/ipratropium
  • budesonide inhaled
  • budesonide rectal
  • palovarotene
  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  • amino acids mixture
  • aminobenzoate potassium
  • elivaldogene autotemcel
  • naproxen and sumatriptan
  • sumatriptan intranasal
  • alglucerase
  • metformin/rosiglitazone
  • ertugliflozin/metformin
  • elosulfase alfa
  • calcium carbonate/magnesium hydroxide
  • starch suppository
  • abicipar pegol (FDA Approval Pending)
  • riboflavin 5′-phosphate ophthalmic
  • povidone ophthalmic
  • glycerin oropharyngeal
  • dimethicone topical
  • menthol topical, dimethicone topical
  • pramoxine topical, menthol topical and dimethicone topical
  • phosphorated carbohydrate
  • brilliant blue G ophthalmic
  • brolucizumab intravitreal
  • purified water, ophthalmic
  • hydroxyethyl cellulose ophthalmic
  • ranibizumab intravitreal implant
  • sodium chloride hypertonic, ophthalmic 
  • cetirizine ophthalmic
  • phentolamine ophthalmic
  • ganciclovir ophthalmic
  • triamcinolone intravitreal
  • ocriplasmin intravitreal
  • atoltivimab/maftivimab/odesivimab
  • pegcetacoplan intravitreal
  • triamcinolone acetonide extended-release injectable suspension
  • tobramycin/loteprednol ophthalmic
  • 2-octyl cyanoacrylate
  • vitamins A & D topical
  • diphenhydramine/allantoin topical
  • pyrethrins/piperonyl butoxide
  • lodoxamide ophthalmic
  • obeticholic acid
  • fluocinolone intravitreal implant
  • sincalide
  • linaclotide
  • nedocromil ophthalmic
  • cysteamine ophthalmic
  • avacincaptad pegol intravitreal
  • azelastine ophthalmic
  • bacitracin ophthalmic
  • propylene glycol ophthalmic
  • rimexolone ophthalmic
  • metoclopramide intranasal
  • mirikizumab
  • netarsudil ophthalmic
  • cenegermin
  • dexamethasone ophthalmic insert
  • prednisolone ophthalmic
  • phenylephrine and cocoa butter rectal
  • phenylephrine and witch hazel topical
  • phenylephrine, pramoxine, glycerin and petrolatum rectal
  • bisacodyl rectal
  • aluminum hydroxide/magnesium carbonate
  • aluminum hydroxide/magnesium hydroxide
  • hyoscyamine spray
  • methenamine/methylene blue/ hyoscyamine/ sodium phosphate monobasic/ phenyl salicylate
  • phenylephrine
  • chlorophyll
  • castor oil
  • cholic acid
  • phenol oropharyngeal
  • articaine/epinephrine
  • antithymocyte globulin equine
  • aluminum hydroxide/magnesium trisilicate
  • methenamine/hyoscyamine
  • hydrocortisone topical/pramoxine topical 
  • sodium fluoride topical
  • mesna
  • C1 esterase inhibitor recombinant
  • menthol and pectin
  • menthol oropharyngeal
  • pectin oropharyngeal
  • gepirone
  • Goldenseal
  • polyethylene glycol and electrolytes
  • polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid
  • brompheniramine/pseudoephedrine/dextromethorphan
  • brompheniramine phenylephrine
  • acetaminophen/doxylamine/phenylephrine
  • doxylamine/acetaminophen/pseudoephedrine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan/phenylephrine
  • eslicarbazepine
  • fluticasone and salmeterol
  • codeine, acetaminophen, butalbital and caffeine
  • codeine, chlorpheniramine and phenylephrine
  • iodine
  • povidone iodine
  • butalbital/aspirin/caffeine/codeine
  • polyethylene glycol 400/propylene glycol ophthalmic 
  • pegvaliase
  • amivantamab
  • iopamidol
  • codeine and pseudoephedrine
  • emtricitabine, rilpivirine, tenofovir DF
  • penicillin G aqueous
  • miconazole topical
  • miconazole vaginal
  • ciprofloxacin inhaled (Pending FDA approval)
  • ceftazidime/avibactam
  • ceftolozane/​tazobactam
  • aztreonam inhalation
  • amphotericin B cholesteryl sulfate
  • miconazole oral
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF
  • isavuconazonium sulfate
  • dapivirine intravaginal (FDA Approval Pending)
  • lamivudine/raltegravir
  • codeine/triprolidine/pseudoephedrine
  • cadexomer iodine
  • brompheniramine/pseudoephedrine
  • codeine/acetaminophen
  • codeine/guaifenesin
  • beclomethasone inhaled
  • epoetin beta/methoxy polyethylene glycol
  • voreloxin(Orphan Drug)
  • rociletinib
  • pitcher plant
  • phosphatidylserine
  • telotristat ethyl
  • copper CU 64 dotatate
  • urea topical
  • exenatide subdermal implant
  • asenapine transdermal
  • ethiodized oil
  • urea oral
  • miglustat
  • acalisib(Investigational)
  • acetophenazine
  • guggul
  • aceneuramic acid
  • mestranol/norethindrone
  • reishi
  • lactitol
  • vonoprazan fumarate
  • motherwort
  • silver nitrate
  • salicylic acid/sulfur shampoo
  • salicylic acid topical
  • ketorolac ophthalmic
  • ketoconazole topical
  • Japanese encephalitis virus vaccine
  • dibucaine topical ointment
  • ketorolac intranasal
  • ketorolac/phenylephrine ophthalmic
  • rotavirus oral vaccine, live
  • guarana
  • hops
  • krill oil
  • salicylic acid/coal tar shampoo
  • sufentanil SL
  • pancrelipase
  • passion flower
  • pepdite one plus
  • nivolumab and relatlimab
  • relatlimab (Pending FDA Approval)
  • benzalkonium chloride/benzocaine
  • ketotifen, drug-eluting contact lens
  • calcitriol topical
  • oxymetazoline topical
  • alclometasone topical
  • capsaicin topical
  • diclofenac/misoprostol
  • diclofenac ophthalmic
  • diclofenac topical
  • pramoxine/calamine topical
  • veverimer
  • tolazoline
  • olopatadine ophthalmic
  • lutetium lu 177-dota-tate
  • lutetium lu 177 vipivotide tetraxetan
  • strontium 89 chloride
  • interferon alfa n3
  • lutetium Lu 177- Diethylenetriamine Pentaacetic acid-omburtamab (FDA Approval Pending)
  • samarium sm 153 lexidronam
  • cytomegalovirus immune globulin (CMV IG)
  • antithymocyte globulin rabbit
  • inolimomab (Pending FDA Approval)
  • olopatadine intranasal
  • olopatadine intranasal/​mometasone, intranasal
  • benzocaine/butamben/tetracaine topical
  • antipyrine/benzocaine/phenylephrine
  • dyclonine/menthol
  • surufatinib
  • fruquintinib
  • dostarlimab
  • hepatitis B immune globulin (HBIG)
  • remestemcel-L
  • benzocaine/menthol oropharyngeal
  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • human rabies immune globulin (HRIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • Methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-hydroxytryptophan (5-htp)
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine, live
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
diphenoxylate/atropine + 

Severity : Monitor Closely
may have an increased CNS depressant effect when combined with CNS depressants

remifentanil

may have an increased CNS depressive effect when combined with opioid agonists

hydrocodone/pseudoephedrine

may have an increased CNS depressive effect when combined with opioid agonists

codeine

may have an increased CNS depressive effect when combined with opioid agonists

morphine

may have an increased CNS depressive effect when combined with opioid agonists

hydroxyzine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

levocabastine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

mepyramine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

acrivastine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

alimemazine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

hydrocodone and homatropine

may have an increased CNS depressant effect when combined with opioid agonists

dezocine

may have an increased CNS depressant effect when combined with opioid agonists

buprenorphine

may have an increased CNS depressant effect when combined with opioid agonists

trimebutine

may have an increased CNS depressant effect when combined with opioid agonists

dextropropoxyphene

may have an increased CNS depressant effect when combined with opioid agonists

hydroxyzine

hydroxyzine may enhance the CNS depressant effect of CNS depressants

lemborexant

lemborexant may enhance the CNS depressant effect of CNS depressants

methotrimeprazine

CNS depressants may enhance the CNS depressant effect of methotrimeprazine

buprenorphine 

may increase the CNS depressant effect

daridorexant 

may enhance the CNS depressant effect

dexmedetomidine 

may enhance the CNS depressant effect

droperidol 

may enhance the CNS depressant effect

zolpidem 

may enhance the CNS depressant effect

chlormethiazole 

may increase the CNS depressant effect

hydroxyzine 

may increase the CNS depressant effect

nalbuphine 

may increase the depressant effect of opioid agonists

paregoric 

may increase the CNS depressant effect of opioid agonists

levorphanol 

may increase the CNS depressant effect

tapentadol 

may increase the CNS depressant of opioid agonists

flunitrazepam 

may have an increased CNS depressant effect when combined with flunitrazepam

lemborexant 

may have an increased CNS depressive effect when combined with CNS depressants

methotrimeprazine 

may have an increased CNS depressive effect when combined with methotrimeprazine

oxycodone 

may have an increased CNS depressive effect when combined with oxycodone

suvorexant 

may have an increased CNS depressive effect when combined with suvorexant

calcium, magnesium, potassium and sodium oxybate 

may have an increased CNS depressant effect when combined with oxybate salt products

ropeginterferon alfa 2b 

may have an increasingly adverse effect when combined with ropeginterferon alfa-2b

remifentanil

may have an increased CNS depressant effect when combined with opioid agonists

hydrocodone/pseudoephedrine

may have an increased CNS depressant effect when combined with opioid agonists

codeine

may have an increased CNS depressant effect when combined with opioid agonists

morphine

may have an increased CNS depressant effect when combined with opioid agonists

methohexital 

may increase the CNS depressant effect of CNS depressants

nalmefene 

nalmefene: they may decrease the therapeutic effect of Opioid Agonists

buprenorphine buccal 

may increase the CNS depressant effect of Buprenorphine

buprenorphine,long-acting injection 

may increase the CNS depressant effect of Buprenorphine

ketazolam 

may increase the risk of CNS depression when combined with 1,2-Benzodiazepine

dexmethylphenidate 

dexmedetomidine: they may increase the CNS depressant effect of CNS Depressants

oxolamine 

oxolamine: they may increase the CNS depressant effect of CNS Depressants

clozapine 

clozapine: they may increase the CNS depressant effect of CNS Depressants

nitrazepam 

nitrazepam: they may increase the CNS depressant effect of CNS Depressants

obinutuzumab 

obinutuzumab: they may increase the CNS depressant effect of CNS Depressants

secretin 

secretin: they may increase the CNS depressant effect of CNS Depressants

cimetropium 

cimetropium: they may increase the CNS depressant effect of CNS Depressants

guanethidine 

guanethidine: they may increase the CNS depressant effect of CNS Depressants

potassium phosphate 

potassium phosphate: they may increase the CNS depressant effect of CNS Depressants

amisulpride 

amisulpride: they may increase the CNS depressant effect of CNS Depressants

tiotropium 

tiotropium: they may increase the CNS depressant effect of CNS Depressants

nitroglycerin 

nitroglycerin: they may increase the CNS depressant effect of CNS Depressants

ramosetron 

ramosetron: they may increase the CNS depressant effect of CNS Depressants

cocaine 

cocaine: they may increase the CNS depressant effect of CNS Depressants

linezolid 

linezolid: they may increase the CNS depressant effect of CNS Depressants

oxychlorosene 

oxychlorosene: they may increase the CNS depressant effect of CNS Depressants

abciximab 

abciximab: it may decrease the excretion rate of abacavir CNS depressant

propoxiphene hydrochloride 

combining CNS depressants with propoxyphene may result in an additive CNS depression

rimonabant 

rimonabant has the potential to intensify the effects of additional central nervous system depressants, including alcohol, benzodiazepines, and opioids, resulting in heightened sedation or respiratory depression

benorilate 

benorilate: it may increase the risk of CNS depression

benoxaprofen 

benoxaprofen: it may increase the risk of CNS depression

alpelisib 

alpelisib: it may increase the risk of CNS depression

alogliptin 

alogliptin: it may increase the risk of CNS depression

albendazole 

albendazole: it may increase the risk of CNS depression

acyclovir 

acyclovir: it may increase the risk of CNS depression

benzydamine 

benzydamine: it may increase the risk of CNS depression

cannabidiol 

cannabidiol: it may increase the risk of CNS depression

capsaicin 

capsaicin: it may increase the risk of CNS depression

captopril 

captopril: it may increase the risk of CNS depression

amobarbital 

amobarbital: it may decreased the serum concentration of CNS depressants

eluxadoline

may have an increased CNS depressant effect when combined with opioid agonists

naldemedine

may have an increased CNS depressant effect when combined with opioid agonists

cimetidine

it increases the effect of diphenoxylate by decreasing the metabolism

glucagon

it increases the effect of atropine when used simultaneously

linezolid

it increases the toxicity of diphenoxylate through an unknown mechanism

macimorelin

when used with atropine, macimorelin shows unspecified drug interaction

phenelzine

it increases the toxicity of diphenoxylate through an unknown mechanism

revefenacin

when used together with atropine, it shows anticholinergic effects

selegiline

it increases the toxicity of diphenoxylate through an unknown mechanism

tranylcypromine

it increases the toxicity of diphenoxylate through an unknown mechanism

azelastine

it increases the effect of CNS depressants

bromperidol

it increases the effect of CNS depressants

kratom

it increases the effect of CNS depressants

olopatadine

it increases the effect of CNS depressants

orphenadrine

CNS depressants increase the effect of orphenadrine

oxomemazine

it increases the effect of CNS depressants

paraldehyde

CNS depressants increase the effect of paraldehyde

bromeperidol

it increases the effect of CNS depressants

bromeperidol 

may increase the CNS depressant effect

thalidomide 

may increase the CNS depressant effect

olopatadine 

may increase the CNS depressant effect

eluxadoline 

may increase the constipation effect of opioid agonist

kratom 

may increase the CNS depressant effect

flunarizine 

CNS depressants increase the effect of flunarizine

orphenadrine 

CNS depressants increase the effect of orphenadrine

oxomemazine 

it increases the effect of CNS depressants

paraldehyde 

CNS depressants increase the CNS depressing effect of paraldehyde

azelastine/fluticasone intranasal 

may increase the CNS depressant effect

flibanserin 

may increase the CNS depressant effect of flibanserin

rasagiline 

may increase the hypertensive effect of Monoamine Oxidase Inhibitors

olopatadine intranasal 

olopatadine (Nasal): they may increase the CNS depressant effect of CNS Depressants

azelaic acid 

azelaic acid: they may increase the CNS depressant effect of CNS Depressants

ipratropium 

ipratropium: they may increase the CNS depressant effect of CNS Depressants

levosalbutamol 

levosalbutamol: they may increase the CNS depressant effect of CNS Depressants

naltrexone 

naltrexone: they may increase the CNS depressant effect of CNS Depressants

furosemide 

furosemide: it may increase the CNS depressant effect of CNS Depressants

aclidinium 

aclidinium: they may increase the CNS depressant effect of CNS Depressants

mequitazine 

mequitazine: they may increase the CNS depressant effect of CNS Depressants

glycopyrrolate 

glycopyrrolate: they may increase the CNS depressant effect of CNS Depressants

chlorthalidone 

chlorthalidone: they may increase the CNS depressant effect of CNS Depressants

revefenacin 

revefenacin: they may increase the CNS depressant effect of CNS Depressants

pitolisant 

pitolisant: they may increase the CNS depressant effect of CNS Depressants

betahistine 

betahistine: they may increase the CNS depressant effect of CNS Depressants

chloral hydrate 

chloral hydrate: they may increase the CNS depressant effect of CNS Depressants

doxofylline 

doxofylline: they may increase the CNS depressant effect of CNS Depressants

brompheniramine

may increase the efficacy of each other when combined

remimazolam

may increase the harmful effects of CNS depressants

primidone

may increase the harmful effects of CNS depressants

phenobarbital

may increase the harmful effects of CNS depressants

amobarbital

may increase the harmful effects of CNS depressants

butalbital

may increase the harmful effects of CNS depressants

alprazolam

diphenoxylate, when used with alprazolam, increases sedation

baclofen

diphenoxylate, when used with baclofen, increases sedation

cinnarizine

diphenoxylate, when used with cinnarizine, increases sedation

droperidol

diphenoxylate, when used with droperidol, increases sedation

hydroxyzine

diphenoxylate, when used with hydroxyzine, increases sedation

lofexidine

diphenoxylate, when used with lofexidine, increases sedation

metaxalone

diphenoxylate, when used with metaxalone, increases sedation

nalbuphine

diphenoxylate, when used with nalbuphine, increases sedation

papaverine

diphenoxylate, when used with papaverine, increases sedation

ziconotide

diphenoxylate, when used with ziconotide, increases sedation

diphenoxylate/atropine

CNS depressants increase the toxicity of CNS depressants

phenobarbital

CNS depressants increase the toxicity of CNS depressants

clozapine

CNS depressants increase the toxicity of CNS depressants

ketamine

CNS depressants increase the toxicity of CNS depressants

propofol

CNS depressants increase the toxicity of CNS depressants

nabilone

may increase the CNS depressant effect of cannabinoid-containing products

cannabidiol

may increase the CNS depressant effect of cannabinoid-containing products

hydrocodone/pseudoephedrine

may increase the CNS depressant effect of opioid agonists

codeine

may increase the CNS depressant effect of opioid agonists

morphine

may increase the CNS depressant effect of opioid agonists

diphenoxylate/atropine

may increase the risk of adverse effect of other CNS depressants

phenobarbital

may increase the risk of adverse effect of other CNS depressants

estazolam

may increase the risk of adverse effect of other CNS depressants

oxazepam

may increase the risk of adverse effect of other CNS depressants

tiagabine

may increase the risk of adverse effect of other CNS depressants

apomorphine

may enhance the adverse/toxic effect of other CNS depressants

flurazepam

may enhance the adverse/toxic effect of other CNS depressants

perphenazine

may enhance the adverse/toxic effect of other CNS depressants

diazepam

may enhance the risk of adverse/toxic effect of other CNS depressants

methadone

may enhance the risk of adverse/toxic effect of other CNS depressants

secobarbital

may enhance the risk of adverse/toxic effect of other CNS depressants

remifentanil

may enhance the CNS depressant effect of Opioid Agonists

hydrocodone/pseudoephedrine

may enhance the CNS depressant effect of Opioid Agonists

codeine

may enhance the CNS depressant effect of Opioid Agonists

morphine

may enhance the CNS depressant effect of Opioid Agonists

clorazepic acid

they increase the toxicity of other CNS depressants

isoflurane

they increase the toxicity of other CNS depressants

promazine

they increase the toxicity of other CNS depressants

famprofazone

may enhance the risk of adverse effect of amphetamines

lisdexamfetamine

may enhance the risk of adverse effect of amphetamines

methamphetamine

may enhance the risk of adverse effect of amphetamines

dextroamphetamine

may enhance the risk of adverse effect of amphetamines

pseudoephedrine

may enhance the risk of adverse effect of amphetamines

eluxadoline

may increase the CNS depressant effect

naldemedine

may increase the CNS depressant effect

droxidopa

could increase the vasopressor action

dextroamphetamine

they decrease the effect of each other by pharmacodynamic antagonism

armodafinil

they decrease the effect of each other by pharmacodynamic antagonism

amphetamine

they decrease the effect of each other by pharmacodynamic antagonism

benzphetamine

they decrease the effect of each other by pharmacodynamic antagonism

caffeine

they decrease the effect of each other by pharmacodynamic antagonism

acamprosate

may have an increased CNS depressant effect when combined with alcohol

lumefantrine

may have an increased CNS depressant effect when combined with alcohol

metamizole

it may enhance the CNS depressant effect

piroxicam

it may enhance the CNS depressant effect

flunarizine

CNS Depressants may enhance the CNS depressant effect of flunarizine

lisuride

lisuride may enhance the CNS depressant effect of CNS Depressants

lofexidine

lofexidine may enhance the CNS depressant effect of CNS depressants

perampanel

perampanel may enhance the CNS depressant effect of CNS Depressants

rotigotine

CNS depressants may enhance the sedative effect of rotigotine

thalidomide

CNS Depressants may enhance the CNS depressant effect of thalidomide

brexanolone

CNS depressants increase the CNS depressing effect of brexanolone

lumefantrine

CNS depressants increase the CNS depressing effect of alcohol

esketamine

it increases the effect of CNS depressants

diphenoxylate/atropine

CNS depressants increase the toxicity of CNS depressants

phenobarbital

CNS depressants increase the toxicity of CNS depressants

clozapine

CNS depressants increase the toxicity of CNS depressants

ketamine

CNS depressants increase the toxicity of CNS depressants

propofol

CNS depressants increase the toxicity of CNS depressants

doxylamine

it increases the effect of CNS depressants

metoclopramide

it increases the effect of CNS depressants

minocycline

it increases the effect of CNS depressants

pramipexole

CNS depressants increase the effect of sedation of pramipexole

ropinirole

CNS depressants increase the effect of sedation of ropinirole

diphenoxylate/atropine

may increase the risk of adverse effect of other CNS depressants

phenobarbital

may increase the risk of adverse effect of other CNS depressants

estazolam

may increase the risk of adverse effect of other CNS depressants

oxazepam

may increase the risk of adverse effect of other CNS depressants

tiagabine

may increase the risk of adverse effect of other CNS depressants

alizapride 

may increase the CNS depressant effect

metoclopramide 

may increase the CNS depressant effect

minocycline 

may increase the CNS depressant effect

amantadine 

may enhance the activity

azelastine 

may increase the CNS depressant effect

difelikefalin 

may increase the CNS depressant effect

lisuride 

may increase the CNS depressant effect

lofexidine 

may increase the CNS depressant effect

magnesium sulfate 

may increase the CNS depressant effect

procarbazine 

may increase the CNS depressant effect

ropinirole 

may increase the sedative effect of CNS depressants

rotigotine 

may increase the sedative effect of CNS depressants

nabilone

may enhance the CNS depressant effect of cannabinoid-containing products

cannabidiol

may enhance the CNS depressant effect of cannabinoid-containing products

apomorphine

may enhance the adverse/toxic effect of other CNS depressants

flurazepam

may enhance the adverse/toxic effect of other CNS depressants

perphenazine

may enhance the adverse/toxic effect of other CNS depressants

bromopride 

it increases the effect of CNS depressants

diazepam

may enhance the risk of adverse/toxic effect of other CNS depressants

methadone

may enhance the risk of adverse/toxic effect of other CNS depressants

secobarbital

may enhance the risk of adverse/toxic effect of other CNS depressants

brimonidine 

may increase the CNS depressant effect

avapritinib 

may increase the toxic effects

brexanolone 

may have an increased CNS depressant effect when combined with brexanolone

may have an increased CNS depressant effect when combined with CNS depressants

doxylamine 

may have an increased CNS depressive effect when combined with CNS depressants

esketamine 

may have an increased CNS depressive effect when combined with CNS depressants

ixabepilone 

may have an increased CNS depressive effect when combined with CNS depressants

magnesium sulfate  

may have an increased CNS depressive effect when combined with CNS depressants

clorazepic acid

they increase the toxicity of other CNS depressants

isoflurane

they increase the toxicity of other CNS depressants

promazine

they increase the toxicity of other CNS depressants

perampanel 

it increases the effect of CNS depressants

rufinamide 

it increases the toxicity of CNS depressants

trimeprazine 

it increases the effect of CNS depressants

fenfluramine 

may have an increased CNS depressant effect when combined with Cyproheptadine

carbinoxamine 

may increase the toxic effect of CNS depressants

carisoprodol 

may increase the toxic effect of CNS depressants

molindone 

may increase the toxic effect of CNS depressants

meprobamate 

may increase the toxic effect of CNS depressants

thiothixene 

may increase the toxic effect of CNS depressants

fexofenadine 

may increase the toxic effect of CNS depressants

promethazine/dextromethorphan 

may increase the toxic effect of other CNS Depressants

sevoflurane 

may increase the adverse effect of CNS Depressants

pramipexole 

pramipexole: they may increase the sedative effect of CNS Depressants

valerian 

valerian: they may increase the CNS depressant effect of CNS Depressants

aripiprazole 

may increase the toxic effect of CNS Depressants

tranylcypromine

may increase the serotonergic effects

isocarboxazid

may increase the serotonergic effects

phenelzine

may increase the serotonergic effects

selegiline

may increase the serotonergic effects

safinamide

may increase the serotonergic effects

tranylcypromine

may increase the serotonergic effects

isocarboxazid

may increase the serotonergic effects

phenelzine

may increase the serotonergic effects

rasagiline

may increase the serotonergic effects

safinamide

may increase the serotonergic effects

acetaminophen/doxylamine/dextromethorphan 

may increase the CNS depressant effect of Doxylamine

metyrosine 

metyrosine: they may increase the sedative effect of CNS Depressants

chloroprocaine 

chloroprocaine: they may increase the CNS depressant effect of CNS Depressants

kava 

kava: they may increase the CNS depressant effect of CNS Depressants

levothyroxine 

levothyroxine: they may increase the CNS depressant effect of CNS Depressants

mianserin 

mianserin: they may increase the CNS depressant effect of CNS Depressants

ozanimod 

ozanimod: they may increase the CNS depressant effect of CNS Depressants

magnesium glucoheptonate

may have an increased CNS depressant effect when combined with CNS depressants

magnesium carbonate

may have an increased CNS depressant effect when combined with CNS depressants

magnesium chloride

may have an increased CNS depressant effect when combined with CNS depressants

magnesium citrate

may have an increased CNS depressant effect when combined with CNS depressants

magnesium gluconate

may have an increased CNS depressant effect when combined with CNS depressants

benzyl alcohol 

benzyl alcohol: they may increase the CNS depressant effect of CNS Depressants

dimethindene 

dimethindene: they may increase the CNS depressant effect of CNS Depressants

piribedil 

piribedil: it may increase the CNS depressant effect of CNS Depressants

potassium citrate 

potassium citrate: they may increase the CNS depressant effect of CNS Depressants

lutropin alfa 

lutropin alfa: they may increase the CNS depressant effect of CNS Depressants

ceritinib 

ceritinib: they may increase the CNS depressant effect of CNS Depressants

dasatinib 

dasatinib: they may increase the CNS depressant effect of CNS Depressants

flecainide 

flecainide: they may increase the CNS depressant effect of CNS Depressants

halofantrine 

halofantrine: they may increase the CNS depressant effect of CNS Depressants

lomitapide 

lomitapide: they may increase the CNS depressant effect of CNS Depressants

methadone 

methadone: they may increase the CNS depressant effect of CNS Depressants

pilsicainide hydrochloride 

pilsiicainide hydrochloride: they may increase the CNS depressant effect of CNS Depressants

glucagon 

glucagon: they may increase the CNS depressant effect of CNS Depressants

hyaluronidase 

hyaluronidase: they may increase the CNS depressant effect of CNS Depressants

mirabegron 

mirabegron: they may increase the CNS depressant effect of CNS Depressants

solriamfetol 

solriamfetol: they may increase the CNS depressant effect of CNS Depressants

tedizolid 

tedizolid: they may increase the CNS depressant effect of CNS Depressants

aminolevulinic acid 

aminolevulinic acid: they may increase the CNS depressant effect of CNS Depressants

sparsentan 

sparsentan: they may increase the CNS depressant effect of CNS Depressants

alfuzosin 

alfuzosin: they may increase the CNS depressant effect of CNS Depressants

arginine 

arginine: they may increase the CNS depressant effect of CNS Depressants

dapoxetine 

dapoxetine: they may increase the CNS depressant effect of CNS Depressants

dexketoprofen 

dexketoprofen: they may increase the CNS depressant effect of CNS Depressants

diacerein 

diacerein: they may increase the CNS depressant effect of CNS Depressants

indoramin 

indoramin: they may increase the CNS depressant effect of CNS Depressants

aliskiren 

aliskiren: they may increase the CNS depressant effect of CNS Depressants

lithium 

lithium: they may increase the CNS depressant effect of CNS Depressants

sacubitril 

sacubitril: they may increase the CNS depressant effect of CNS Depressants

aprotinin 

aprotinin: they may increase the CNS depressant effect of CNS Depressants

methylphenidate 

methylphenidate: they may increase the CNS depressant effect of CNS Depressants

molsidomine 

molsidomine: they may increase the CNS depressant effect of CNS Depressants

naftopidil 

naftopidil: they may increase the CNS depressant effect of CNS Depressants

pholcodine 

pholcodine: they may increase the CNS depressant effect of CNS Depressants

urokinase 

urokinase: they may increase the CNS depressant effect of CNS Depressants

lumefantrine

may increase the CNS depressant effect of CNS depressants

abacavir 

abacavir: it may decrease the excretion rate of abacavir CNS depressant

abatacept 

abatacept: it may decrease the excretion rate of abacavir CNS depressant

acebutolol 

acebutolol: it may decrease the excretion rate of abacavir CNS depressant

aceclofenac 

aceclofenac: it may decrease the excretion rate of abacavir CNS depressant

acemetacin 

acemetacin: it may decrease the excretion rate of abacavir CNS depressant

acenocoumarol 

acenocoumarol: it may decrease the excretion rate of abacavir CNS depressant

acetohexamide 

acetohexamide: it may decrease the excretion rate of abacavir CNS depressant

aldesleukin 

aldesleukin: it may decrease the excretion rate of abacavir CNS depressant

alefacept 

alefacept: it may decrease the excretion rate of abacavir CNS depressant

allopurinol 

allopurinol: it may decrease the excretion rate of abacavir CNS depressant

bacitracin 

bacitracin: it may decrease the excretion rate of abacavir CNS depressant

baricitinib 

baricitinib: it may decrease the excretion rate of abacavir CNS depressant

benazepril 

benazepril: it may decrease the excretion rate of abacavir CNS depressant

benserazide 

benserazide: it may decrease the excretion rate of abacavir CNS depressant

acetazolamide 

acetazolamide: it may increase the risk or severity of CNS depression

balsalazide 

balsalazide: it may increase the risk or severity of CNS depression

mepyramine 

mepyramine: it may increase the risk or severity of CNS depression

acrivastine 

acrivastine: it may increase the risk or severity of CNS depression

adenosine 

adenosine: it may increase the risk or severity of CNS depression

ajmaline 

ajmaline: it may increase the risk or severity of CNS depression

alfentanil 

alfentanil: it may increase the risk or severity of CNS depression

alprazolam 

alprazolam: it may increase the risk or severity of CNS depression

baclofen 

baclofen: it may increase the risk or severity of CNS depression

alvimopan 

alvimopan: it may increase the risk or severity of CNS depression

bufexamac 

bufexamac: it may increase the risk or severity of CNS depression

butabarbital 

butabarbital: it may increase the risk or severity of CNS depression

carbidopa 

carbidopa: it may increase the risk or severity of CNS depression

carboplatin 

carboplatin: it may increase the risk or severity of CNS depression

carmustine 

carmustine: it may increase the risk or severity of CNS depression

carprofen 

carprofen: it may increase the risk or severity of CNS depression

carvedilol 

carvedilol: it may increase the risk or severity of CNS depression

dalfampridine 

dalfampridine: it may increase the risk or severity of CNS depression

cefaclor 

cefaclor: it may increase the risk or severity of CNS depression

bedaquiline 

bedaquiline: it may increase the risk or severity of CNS depression

cariprazine 

cariprazine: it may increase the risk or severity of CNS depression

cetirizine (systemic) 

cetirizine: it may increase the risk or severity of CNS depression

celiprolol 

celiprolol: it may increase the risk or severity of CNS depression

dabrafenib 

dabrafenib: it may increase the risk or severity of CNS depression

dapagliflozin 

dapagliflozin: it may increase the risk or severity of CNS depression

alosetron 

alosetron: it may increase the risk or severity of CNS depression

benzphetamine 

benzphetamine: it may increase the risk or severity of CNS depression

agomelatine 

agomelatine: it may increase the risk or severity of CNS depression

metocurine 

metocurine: it may increase the risk or severity of CNS depression

amoxicillin 

amoxicillin: it may increase the risk or severity of CNS depression

ampicillin 

ampicillin: it may increase the risk or severity of CNS depression

anagrelide 

anagrelide: it may increase the risk or severity of CNS depression

apomorphine 

apomorphine: it may increase the risk or severity of CNS depression

benzylpenicillin 

benzylpenicillin: it may increase the risk or severity of CNS depression

amphetamine 

amphetamine: it may decreased the serum concentration of CNS depressants

anakinra 

anakinra: it may decreased the serum concentration of CNS depressants

antipyrine 

antipyrine: it may decreased the serum concentration of CNS depressants

arbutamine 

arbutamine: it may decreased the serum concentration of CNS depressants

arformoterol 

arformoterol: it may decreased the serum concentration of CNS depressants

binimetinib 

binimetinib: it may increase the metabolism of CNS depressants

bortezomib 

bortezomib: it may increase the metabolism of CNS depressants

brivaracetam 

brivaracetam: it may increase the metabolism of CNS depressants

cenobamate 

cenobamate: it may increase the metabolism of CNS depressants

chlordiazepoxide 

chlordiazepoxide: it may increase the metabolism of CNS depressants

chlorpromazine 

chlorpromazine: it may increase the metabolism of CNS depressants

oxybuprocaine 

oxybuprocaine: it may increase the metabolism of CNS depressants

axitinib 

axitinib: it may increase the metabolism of CNS depressants

pergolide 

pergolide: it may increase the risk of CNS depression

boceprevir 

boceprevir: it may increase the risk of CNS depression

bosentan 

bosentan: it may increase the risk of CNS depression

bretylium 

bretylium: it may increase the risk of CNS depression

brexpiprazole 

brexpiprazole: it may increase the risk of CNS depression

hyoscine butylbromide 

the sedative property of hyoscine may be increased

diphenhydramine 

this preparation contains diphenhydramine and may enhance the impact of alcohol and other central nervous system depressants, including opioid analgesics, anticonvulsants, antihistamines, antidepressants, antiemetics, anxiolytic sedatives, antipsychotics, and hypnotics

clomipramine

it increases the toxicity of atropine through an unknown mechanism

lofepramine

it increases the toxicity of atropine through an unknown mechanism

protriptyline

it increases the toxicity of atropine through an unknown mechanism

trimipramine

it increases the toxicity of atropine through an unknown mechanism

alizapride

it increases the effect of CNS depressants

primidone

CNS depressants increases the concentration of serum barbiturates in the serum

phenobarbital

CNS depressants increases the concentration of serum barbiturates in the serum

amobarbital

CNS depressants increases the concentration of serum barbiturates in the serum

butalbital

CNS depressants increases the concentration of serum barbiturates in the serum

butabarbital

CNS depressants increases the concentration of serum barbiturates in the serum

bromopride

it increases the effect of CNS depressants

bupivacaine

CNS depressants increases the toxicity of bupivacaine

difelikefalin

it increases the effect of CNS depressants

magnesium sulfate

it increases the effect of CNS depressants

procarbazine

it increases the effect of CNS depressants

blonaserin

CNS depressants increase the effect of blonanserin

daridorexant

it increases the effect of CNS depressants

droperidol

it increases the effect of CNS depressants

oxycodone

CNS depressants increase the effect of oxycodone

zolp

CNS depressants increase the effect of zolpidem

zolpidem

CNS depressants increase the effect of zolpidem

suvorexant

CNS depressants increase the effect of suvorexant

zuranolone 

it increases the effect of CNS depressants

 

Dosage forms & Strengths 

Tablet 

2.5 mg/0.025 mg 

Solution
2.5mg/0.025mg/5mL 

Diarrhea 

diphenoxylate is used in combination with atropine to treat diarrhea
5 mg of diphenoxylate with 0.05 mg of atropine is prescribed every 6 hours as 2 tablets orally
The drug should not be administered more than 20 mg per day
Discontinue the treatment if clinical improvement is not seen within 10 days



 

Dosage forms & Strengths 

Tablet 

2.5 mg/0.025 mg 

Solution
2.5mg/0.025mg/5mL 

Diarrhea 

Children of 2 to 13 years of age are only administered with a liquid formulation
<2 years- safety and efficacy are not seen for children under two
2 years- 1.5 to 3 ml orally every 6 hours
3 years- 2 to 3 ml orally every 6 hours
4 years- 2 to 4 ml orally every 6 hours
5 years- 2.5 to 4.5 ml orally every 6 hours
6 to 8 years- 2.5 to 5 ml orally every 6 hours
9 to 12 years- 3.5 to 5 ml every orally every 6 hours



 

Refer to the adult dosing 

1-10% 

Abdominal discomfort 

Anticholinergic effects 

Blurred vision 

Dryness of skin/mouth 

Nausea 

Vomiting 

Sedation 

Frequency not defined 

Pancreatitis 

Toxic megacolon 

Diphenoxylate/atropine is contraindicated in children under 6 years of age due to the risk of respiratory depression, coma, and death, especially when overdosed. Extreme caution must be used when administering this medication to pediatric patients, and it should never be used in children under the age of 2. Use only the lowest effective dose for the shortest possible duration to minimize the risk of serious adverse effects. 

Contraindication/Caution: 

Allergy or hypersensitivity to diphenoxylate, atropine, or any of the ingredients in the formulation. 

  • Severe liver disease or hepatic encephalopathy, as the medication may worsen these conditions. 
  • Infectious diarrhea caused by bacteria, viruses, or parasites, as the medication may slow down the elimination of the infectious agent and delay the resolution of the infection. 
  • Glaucoma or other eye conditions that can be worsened by the anticholinergic effects of atropine. 
  • Respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD), as the medication may cause respiratory depression or worsen these conditions. 
  • Pregnancy or breastfeeding, as the safety and efficacy of the medication have not been established in these populations. 

Caution should also be exercised when using diphenoxylate/atropine in patients with certain medical conditions, such as inflammatory bowel disease, kidney disease, or heart disease, as well as in patients taking other medications that may interact with diphenoxylate/atropine. The medication may cause drowsiness, dizziness, or impaired coordination, so patients should avoid driving or operating heavy machinery until they know how the medication affects them. 

Pregnancy consideration: diphenoxylate/atropine should be used in pregnancy only if the assumed benefits outweigh potential risks 

Breastfeeding warnings: Some of the active metabolites of the diphenoxylate are secreted in breastmilk but are unknown for atropine 

Hence consult your physician for the same 

Pregnancy category: 

  • Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. 
  • Category B: There is no affirmation of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women. 
  • Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a product in humans; Pregnant women must take care of the potential risks. 
  • Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms. However, despite potential dangers may be used only in emergency cases for potential benefits. 
  • Category X: Drugs listed in this category outweigh risks over benefits. The drug is not for pregnant women. 
  • Category N: No data is available for the drug under this category. 

Pharmacology: 

diphenoxylate/atropine is a combination medication used for the treatment of diarrhea. diphenoxylate is an opioid medication that works by slowing down the movement of the intestines and reducing the frequency and volume of bowel movements. Atropine is added to the medication to discourage abuse of diphenoxylate, which can be addictive if taken in large amounts. 

Pharmacodynamics: 

diphenoxylate is a synthetic opioid agonist that binds to the mu-opioid receptors in the gastrointestinal tract, which slows down the propulsive contractions of the smooth muscle and reduces the secretions in the intestinal tract. This results in reduced peristalsis and increased transit time, which leads to decreased frequency and volume of bowel movements. 

atropine is an antimuscarinic agent that works by blocking the action of acetylcholine at muscarinic receptors in the gastrointestinal tract. atropine inhibits the secretions in the intestinal tract and reduces smooth muscle contractions, which results in a further decrease in bowel movement frequency and volume. 

Pharmacokinetics: 

diphenoxylate is absorbed slowly and incompletely from the gastrointestinal tract. The drug is metabolized in the liver, primarily by glucuronidation, and the metabolites are excreted in the urine. 

atropine is rapidly absorbed from the gastrointestinal tract and is widely distributed throughout the body. The drug is metabolized in the liver and excreted primarily in the urine. 

Administration: 

diphenoxylate/atropine is available as a tablet and is typically taken orally. The recommended dose for adults is 2 tablets (2.5 mg diphenoxylate/0.025 mg atropine per tablet) four times a day or as directed by a healthcare provider. The medication should be taken with a full glass of water. 

It is important to follow the dosing instructions provided by the healthcare provider and not exceed the recommended dose. Diphenoxylate has the potential for abuse and addiction, and taking more than the recommended dose or taking it for longer than prescribed can lead to dependence. 

Patients should not take diphenoxylate/atropine for more than 48 hours without consulting a healthcare provider. If symptoms persist or worsen after 48 hours of treatment, a healthcare provider should be consulted to rule out underlying conditions. Patients should also avoid alcohol while taking diphenoxylate/atropine, as alcohol can increase the sedative effects of the medication. 

In addition to taking diphenoxylate/atropine as directed, patients should also maintain good hydration by drinking plenty of fluids to replace those lost due to diarrhea. Electrolyte replacement solutions may also be recommended in severe cases of diarrhea.

Patient information leaflet 

Generic Name: diphenoxylate/atropine 

Pronounced: dahy-fen-ok-suh-leyt -atruh-peen 

Why do we use diphenoxylate/atropine? 

diphenoxylate/atropine is used to treat acute or chronic diarrhea in adults. It is a combination medication that contains diphenoxylate, an opioid medication that slows down the movement of the intestines and reduces the frequency and volume of bowel movements, and atropine, which is added to the medication to discourage its abuse. 

Diarrhea can result from a variety of causes, including infections, medications, and digestive disorders. The goal of treatment is to reduce the frequency and volume of bowel movements and to alleviate associated symptoms such as cramping, abdominal pain, and dehydration. 

diphenoxylate/atropine can help to slow down the movement of the intestines and reduce the volume and frequency of bowel movements, thereby helping to alleviate the symptoms of diarrhea. atropine is added to the medication to discourage its abuse, as diphenoxylate can be addictive if taken in large amounts. 

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diphenoxylate/atropine

Brand Name :

Lomotil

(United States) [Available]
×

Brand Name :

country status Month Year
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Synonyms :

diphenoxylate/atropine

Class :

Gastrointestinal agents; Antidiarrheal drugs; Antimotility agents

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No data available for drug.

Dosage forms & Strengths 

Tablet 

2.5 mg/0.025 mg 

Solution
2.5mg/0.025mg/5mL 

Diarrhea 

diphenoxylate is used in combination with atropine to treat diarrhea
5 mg of diphenoxylate with 0.05 mg of atropine is prescribed every 6 hours as 2 tablets orally
The drug should not be administered more than 20 mg per day
Discontinue the treatment if clinical improvement is not seen within 10 days



Dosage forms & Strengths 

Tablet 

2.5 mg/0.025 mg 

Solution
2.5mg/0.025mg/5mL 

Diarrhea 

Children of 2 to 13 years of age are only administered with a liquid formulation
<2 years- safety and efficacy are not seen for children under two
2 years- 1.5 to 3 ml orally every 6 hours
3 years- 2 to 3 ml orally every 6 hours
4 years- 2 to 4 ml orally every 6 hours
5 years- 2.5 to 4.5 ml orally every 6 hours
6 to 8 years- 2.5 to 5 ml orally every 6 hours
9 to 12 years- 3.5 to 5 ml every orally every 6 hours



Refer to the adult dosing 

DRUG INTERACTION

diphenoxylate/atropine

&

  • Pembrolizumab / Berahyaluronidase
  • Bumetanide Intranasal
  • Gemcitabine intravesical
  • Rilzabrutinib
  • Zopapogene
  • Aceclidine
  • aluminium hydroxide
  • benzralizumab (Rx)
  • Rituximab
  • Trimetrexate Glucuronate
  • Mirdametinib
  • Suzetrigine
  • Potassium acid phosphate
  • Acellular Tissue Engineered Vessel
  • crinecerfont (pending approval from FDA)
  • Revumenib
  • pembrolizumab (Rx)
  • azathioprine (Rx)
  • Gemcitabine (Rx)
  • Seladelpar
  • Atezolizumab / Hyaluronidase-tqjs
  • Axatilimab-csfr
  • Afamitresgene Autoleucel
  • Lazertinib
  • Ocrelizumab / Hyaluronidase ocsq
  • Lebrikizumab
  • naloxone intranasal
  • clomiphene
  • patisiran
  • imetelstat
  • phenylephrine ophthalmic
  • myoinositol
  • vasicinone
  • soda lime
  • fisetin
  • Reynoutria Japonica
  • Coco Monoethanolamide
  • Betadex
  • lithopone
  • cyperus rotundus
  • papaya juice
  • 1-naphthaleneacetic acid
  • Nordazepam
  • Glechoma hederacea
  • Alternanthera sessilis
  • nicofetamide
  • napthol asol
  • cocamidopropyl betaine
  • musa x paradisiaca
  • dicyclomine/mefenamic acid
  • Sorghum
  • Manganese citrate
  • tovorafenib
  • mefenamic acid/paracetamol
  • eschscholzia californica
  • canna indica root
  • tranexamic acid/mefenamic acid
  • dexverapamil
  • sitogluside
  • secalciferol
  • cefatrizine
  • Sedum Acre
  • Flurogestone
  • Fluocortin
  • Bifendate
  • piprozolin
  • aminacrine undecylate
  • ethylenediamine mandelate
  • pelubiprofen
  • hesperetin
  • butethamine
  • epitiostanol
  • androstenediol
  • Nitroxoline
  • Iocarmic acid
  • Capobenic acid
  • dordaviprone (investigational drug)
  • Vitexin
  • Friluglanstat (investigational drug)
  • scorias spongiosa
  • Luseogliflozin
  • indoxacarb
  • prademagene zamikeracel
  • fidanacogene elaparvovec-dzkt
  • albifylline
  • idanpramine
  • araneus diadematus
  • Sulfamazone
  • Lycosa tarantula
  • malotilate
  • Ethacizine
  • Namilumab
  • Latrunculin B
  • stachyose
  • platinic oxide
  • iopronic acid
  • calcium chloride / potassium chloride/lactic acid/ sodium chloride/sodium hydroxide/sodium lactate solution
  • citric acid/ sodium bicarbonate/ sodium carbonate anhydrous
  • vadadustat
  • permethrin medical grade cis/trans isomers 25/75
  • lutetium, isotope of mass 177
  • human normal immunoglobulin
  • sacrosidase
  • apadamtase alfa, recombinant
  • acetyl hexapeptide-8 amide
  • pemivibart (Investigational)
  • govorestat
  • Zanidatamab
  • sotatеrcеpt
  • MV 140 vaccine
  • leuprorelin implant
  • cinchocaine hydrochloride/fluocortolone hexanoate/fluocortolone pivalate
  • Beautyberry
  • risedronate/calcium/vitamin D3
  • rhubarb extract/senna leaf/sulphur purified/wood charcoal
  • boric acid/kaolin/methyl salicylate/peppermint oil/thymol
  • docosahexaenoic acid/eicospentaenoic acid
  • aluminium hydroxide/magnesium hydroxide/simethicone
  • gentamicin/hydrocortisone
  • succinylcholine
  • sinefungin
  • letibotulinumtoxinA
  • coal tar/coconut oil/salicylic acid
  • camphor/camphor oil white/capsicum oleoresin /menthol/methyl salicylate
  • thioglycolic acid
  • acetic acid auricular
  • roluperidone
  • hydrocortisone/crotamiton topical
  • nystatin/chlorhexidine
  • aluminium chloride hexahydrate
  • ketoprofen topical
  • Chlormethine
  • podophyllotoxin
  • urea/lactic acid
  • autologous chondrocytes implant
  • afelimomab
  • gepotidacin
  • fludroxycortide
  • fentanyl transdermal
  • erythromycin/zinc acetate
  • dibotermin alfa powder
  • desferrioxamine mesilate
  • choline salicylate/magnesium salicylate
  • castor oil/peru balsam/trypsin
  • betamethasone/dexchlorpheniramine maleate
  • benzalkonium chloride solution/cetrimide
  • barzolvolimab
  • ascorbic acid / calcium laevulinate / nicotinamide / calcium pantothenate / calcium chloride / riboflavine / pyridoxine hydrochloride / thiamine hydrochloride
  • argipressin
  • arachis oil refined/chlorobutanol hemihydrate
  • arachis oil/eucalyptol/nutmeg oil/terpineol
  • ammonium chloride/diphenhydramine hydrochloride/levomenthol
  • amino acid mixture d / calcium chloride dihydrate / glucose monohydrate / glycine / magnesium chloride hexahydrate / olive oil / potassium chloride / sodium acetate trihydrate / sodium glycerophosphate pentahydrate / soya-bean oil
  • biotin/colecalciferol/copper (ii)sulfate dried/ cyanocobalamine/ dl-alpha tocopherol acetate/dibasic calcium phosphate anhydrous/folic acid/iron (ii)sulfate dried/ lecithin/ magnesium sulfate dried/ nicotinamide/ pyridoxine hydrochloride/ riboflavin
  • ampicillin sodium / cloxacillin sodium
  • undecylenic acid, undecylenate salts, zincundecate
  • omeprazole/sodium bicarbonate
  • efgartigimod alfa/hyaluronidase
  • xylometazoline/ipratropium
  • cefepime and enmetazobactam
  • isotonic sodium chloride
  • bee venom allergen injection
  • fentanyl intranasal
  • alglucosidase alfa
  • triprolidine/pseudoephedrine
  • pegademase bovine
  • castor oil and peru balsam
  • camphor/eucalyptus oil/menthol
  • oxyquinoline/sodium lauryl sulfate
  • somatorelin
  • menotrophin injection
  • menadiol
  • hylan g-f 20
  • cefepime and taniborbactum
  • water avens
  • camphor/menthol
  • acoramidis
  • elafibranor
  • arrowroot
  • miconazole nitrate/hydrocortisone
  • vildagliptin/metformin
  • dobesilic acid
  • aroxybutynin and atomoxetine
  • hygromycin
  • linvoseltamab
  • nemolizumab
  • aceprometazine
  • limaprost
  • oxazolam
  • trimegestone
  • teceleukin
  • beauty berry
  • dinotefuran
  • imiprothrin
  • transfluthrin
  • thymalfasin
  • technetium Tc 99m tilmanocept
  • glepaglutide
  • marstacimab
  • pixantrone
  • Andiroba
  • arabinoxylan
  • arenaria rubra
  • etripamil
  • jequirity
  • jiaogulan
  • dusquetide
  • rolipram
  • tradipitant
  • sinfungin
  • diclofenac/omeprazole
  • brinzolamide and timolol maleate
  • wormseed
  • wormwood
  • wood sorrel
  • carmellose sodium
  • ibandronic acid
  • cinnarizine and dimenhydrinate
  • ursodeoxycholic acid
  • rhubarb extract/salicylic acid
  • butamirate citrate
  • fumitory
  • taheebo
  • uva ursi
  • vervain
  • coleus
  • coltsfoot
  • crampbark
  • plantain
  • potassium nitrate and silver nitrate
  • gelsemium
  • gentian
  • glucomannan
  • walnut
  • meadowsweet
  • midomafetamine
  • pennyroyal
  • periwinkle
  • betony
  • bitter orange
  • bladderwrack
  • bloodroot
  • emu oil
  • garcinia
  • yellow dock
  • burdock
  • dehydroepiandrosterone
  • aucubin
  • jasmone
  • resacetophenone
  • ecamsule ditriethanolamine
  • feclobuzone
  • fenoprop triethanolamine
  • verdyl acetate
  • caffeic acid
  • cyclamen aldehyde
  • dicetyldimonium chloride
  • wogonin
  • impacarzine
  • laurylpyridinium chloride
  • stepronin
  • matrine
  • sakuranin
  • cannabichromene
  • sandalore
  • sabinene
  • oxypaeoniflora
  • ethylhexyl pelargonate
  • acrylonitrile
  • allyl alcohol
  • dipalmitoylethyl hydroxyethylmonium methosulfate
  • butidrine
  • clothiapine
  • propanediol dicaprylate
  • buchu
  • undecanol
  • enilconazole
  • xymenynic acid
  • angelica
  • nizubaglustat
  • resomelagon
  • ulecaciclib
  • apple cider vinegar
  • bacopa
  • barley grass
  • dandelion
  • deer velvet
  • dolomite
  • bugleweed
  • bupleurum
  • glyceryltrinitrate
  • pociredir
  • asnuciclib
  • actalycabtagene autoleucel
  • butantan–dengue vaccine
  • travoprost/timolol
  • furosemide/potassium chloride
  • amylamine
  • jaborandi
  • patritumab deruxtecan
  • jackfruit
  • sterculia
  • ascorbigen
  • ashitaba
  • androstenetrione
  • andrachne
  • cosibelimab
  • racecadotril
  • neomycin/chlorhexidine
  • octocog alfa
  • cetrimide
  • ispaghula husk
  • polyhexanide
  • octenidine
  • polygeline
  • heparinoid
  • jewelweed
  • boldo
  • anizatrectinib
  • alpinia
  • henbane
  • cynanchum vincetoxicum root and sulfur
  • boditrectinib
  • izumerogant
  • zavondemstat
  • abuta
  • fadogia agrestis
  • fly agaric mushroom
  • meptazinol
  • methoxyflurane
  • tramadol/dexketoprofen
  • betaine/polyhexanide
  • filgotinib
  • inosine acedoben dimepranol
  • alverine citrate
  • hyoscine butylbromide
  • senna+ ispaghula
  • cabbage palm
  • cajeput oil
  • calanus oil
  • calamint
  • canada balsam
  • carnosine
  • alverine citrate/simeticone
  • dihydroartemisinin/piperaquine
  • mebeverine/ispaghula
  • calcipotriol
  • tacalcitol
  • triethyl citrate/ethyl linoleate
  • sodium dilauramidoglutamide lysine
  • fazamorexant
  • avibactam tomilopil and ceftibuten
  • drostanolone
  • tigilanol tiglate
  • isorhynchophylline
  • rhynchophylline
  • crisugabalin
  • epigallocatechin gallate
  • clomocycline
  • corynoxeine
  • isocorynoxeine
  • Culmerciclib
  • Neladenoson
  • ambrein
  • hexylcaine
  • phensuximide
  • resencatinib (investigational)
  • rolusafine
  • pumecitinib
  • arhalofenic acid
  • berdazimer sodium
  • benzquinamide
  • clidinium
  • sulfametopyrazine
  • fulzerasib (Investigational Drug)
  • rovadicitinib (Investigational Drug)
  • Upleganan (Investigational Drug)
  • menthyl ethylamido oxalate
  • quaternium-90 montmorillonite
  • unecritinib (investigational drug)
  • etohexadiol
  • guaiol
  • proximadiol
  • verdinexor
  • sofnobrutinib
  • talbutal
  • ethoxzolamide
  • propiomazine
  • enprofylline
  • phenmetrazine
  • merigolix
  • pralurbactam
  • neracorvir
  • vonifimod
  • apaziquone hydroquinone
  • darizmetinib
  • zandelisib
  • xininurad
  • ritivixibat
  • amiselimod phosphate (investigational drug)
  • emzeltrectinib (investigational drug)
  • ficonalkib
  • cinalukast
  • ulobetasol
  • candoxatril
  • nitrofural
  • acetyldigitoxin
  • bentiromide
  • dextrothyroxine
  • chlorotrianisene
  • remikiren
  • pipobroman
  • vidarabine
  • immune globulin intravenous, human-stwk
  • spermine
  • serine
  • N-acetyl glucosamine
  • valine
  • adenine
  • asparagine
  • citrulline
  • adinazolam
  • interferon alfacon-1
  • interferon alfa-n1
  • felypressin
  • birch triterpenes
  • pyridoxal phosphate
  • technetium Tc-99m arcitumomab
  • beta-alanine
  • dihomo-gamma-linolenic acid
  • urea/hydrocortisone
  • R21/Matrix-M vaccine
  • povidone-iodine (ophthalmic)
  • pheniramine
  • hydrocortisone rectal
  • chloroxylenol/pramoxine/zinc acetate
  • chloroxylenol/pramoxine
  • dextrose/sucrose/vitamin C/zinc sulphate
  • furazolidone/metronidazole/dicyclomine
  • ergocalciferol (vitamin D2)
  • benoxaprofen (discontinued)
  • teicoplanin
  • carbomer
  • chromic chloride / iron (ii) chloride tetrahydrate / potassium iodide / manganese chloride / sodium fluoride / sodium selenite pentahydrate / sodium molybdate dihydrate / zinc chloride/ cupric chloride
  • bufylline
  • lidocaine/prilocaine
  • opium tincture, squill oxymel
  • dibrompropamidine
  • metronidazole/tetracycline/bismuth subsalicylate
  • agnus- castus
  • velaglucerase alfa
  • alendronic acid / colecalciferol
  • bimatoprost / timolol
  • efbemalenograstim alfa
  • dried ferrous sulfate/folic acid
  • dried ferrous sulfate / sodium ascorbate
  • nirogacestat
  • soya-bean oil, medium-chain triglycerides
  • demeclocycline hydrochloride and triamcinolone acetonide
  • fusidic acid / hydrocortisone acetate
  • macrogol
  • storax, benzoin
  • nomegestrol acetate/estradiol
  • flumetasone pivalate/ clioquinol
  • berdazimer topical (Pending FDA Approval)
  • buflomedil
  • butobarbital
  • andexanet alfa
  • methoxypolyethylene glycol-epoetin beta
  • viscum abietis
  • pramoxine vaginal
  • bupivacaine implant
  • cromolyn sodium, inhaled
  • pneumococcal vaccine 20-valent
  • bimatoprost ophthalmic implant
  • tick-borne encephalitis vaccine
  • chloroprocaine ophthalmic
  • travoprost intraocular implant (Pending FDA approval)
  • typhoid polysaccharide vaccine
  • sodium phosphate
  • human papillomavirus vaccine, nonavalent
  • peanut immunotherapy epicutaneous (FDA approval pending)
  • cromolyn sodium, intranasal
  • red blood cells(Blood component)
  • oral mucoadhesive
  • clindamycin vaginal
  • whole blood (Blood Component)
  • fibrinogen/thrombin
  • levothyroxine/liothyronine
  • ipratropium intranasal
  • metronidazole vaginal
  • cyamemazine
  • brinase
  • reviparin
  • ulinastatin
  • saruplase
  • acepromazine
  • emylcamate
  • methionine
  • amino acids and electrolytes in dextrose with calcium
  • slippery elm
  • camostat
  • hemoglobin crosfumaril
  • moperone
  • chlormidazole
  • brilaroxazine
  • palopegteriparatide
  • diazepam buccal
  • benegrastim (pending for FDA approval)
  • COVID-19 vaccine, adjuvanted-Novavax
  • vestronidase alfa-vjbk
  • tebipenem (Pending FDA Approval)
  • tislelizumab (Pending FDA Approval)
  • zolbetuximab (Pending FDA Approval)
  • zoliflodacin (pending FDA approval)
  • zibotentan and dapagliflozin
  • fluorine F18 DCFPyL
  • debamestrocel
  • givinostat
  • amubarvimab and romlusevimab(Pending FDA Approval)
  • sabizabulin(Pending FDA approval)
  • fexapotide(Phase 3 Clinical trial)
  • diatrizoic acid
  • drotaverine
  • diethyl phthalate
  • enclomiphene
  • epalrestat
  • ethamsylate
  • flupirtine
  • imidurea
  • sodium glycolate
  • feracrylum
  • ethacridine
  • furazolidone/metronidazole
  • ozagrel hydrochloride
  • leptazol
  • l-glutamic acid /vitamin B complex
  • etizolam
  • etizolam/propranolol
  • ethoheptazine citrate
  • etophylline and theophylline
  • etophylline
  • finger millet
  • drotaverine/mefenamic acid
  • dichloroxylenol
  • pneumococcal 7-valent vaccine
  • diclofenac and metaxalone
  • dipivefrin ophthalmic
  • enbucrilate
  • potassium citrate and citric acid
  • potassium gluconate
  • aclarubicin
  • alfuzosin/dutasteride
  • adrenochrome monosemicarbazone
  • selenium sulfide topical
  • sertaconazole
  • amorolfine cream
  • amsacrine
  • amylmetacresol
  • sulfonated phenolics in aqueous solution
  • technetium Tc-99m sulfur colloid
  • raltitrexed
  • romiplostim
  • acediasulfone
  • azulene
  • acebrophylline
  • clonazepam/escitalopram oxalate
  • allylestrenol
  • andrographolide
  • artemotil
  • technetium Tc-99m sestamibi
  • rubidium Rb-82
  • somapacitan
  • sodium sulfate, magnesium sulfate and potassium sulfate
  • almitrine
  • gramicidin
  • nikethamide
  • technetium Tc-99m sodium pertechnetate
  • betiatide
  • prilocaine/epinephrine
  • amlexanox
  • acetaminophen/salicylamide/phenyltoloxamine
  • neomycin topical
  • zilucoplan
  • antazoline and xylometazoline
  • toripalimab
  • iron isomaltoside
  • meningococcal A C Y and W polysaccharide tetanus toxoid conjugate vaccine
  • meningococcal A C Y and W-135 diphtheria conjugate vaccine
  • tetradecyl Sulfuric Acid
  • benzoyl peroxide, clindamycin phosphate, adapalene
  • ethylephedrine
  • actarit
  • pyrantel tartrate
  • tenofovir disoproxil fumarate or tenofovir DF
  • melitracen
  • amitriptylinoxide(Phase 4 Clinical Trials)
  • threonine
  • ditiocarb zinc
  • epicriptine
  • levallorphan
  • kinetin
  • laurocapram
  • pentagastrin
  • parthenolide
  • nicoboxil
  • protionamide
  • prulifloxacin
  • proscillaridin
  • tizanidine and rofecoxib
  • tolnaftate, gentamicin, chinoform and betamethasone valerate
  • pine bark extract
  • pipenzolate methylbromide
  • bephenium hydroxynaphthoate
  • niclosamide
  • pyrvinium
  • pipenzolate methylbromide/phenobarbitone
  • piracetam/ginkgo biloba/vinpocetine
  • benzyl benzoate/disulfiram
  • benzyl benzoate
  • loperamide/simethicone
  • piroctone olamine
  • sodium fusidate
  • piroxicam topical/capsaicin/menthol/methyl salicylate
  • sodium metabisulfite
  • sodium lauryl sulfate
  • taspoglutide
  • glyclopyramide
  • tolnaftate, gentamicin, iodochlorohydroxyquinoline, chlorocresol, betamethasone valerate
  • serratiopeptidase
  • sodium antimony gluconate
  • triamterene / benzthiazide
  • tribenoside / lidocaine
  • triclocarban
  • triprolidine/dextromethorphan  
  • vitamins/minerals/omega-3 Fatty acids
  • soyabean oil
  • sucralfate/oxethazaine
  • sucralfate/tinidazole/povidone iodine
  • sodium cromoglycate
  • aloe vera/liquid paraffin/white soft paraffin
  • aloe vera/jojoba oil/vitamin E
  • allantoin/triclosan/vitamin e/zinc oxide
  • alpha-Lipoic acid/minerals/multivitamins
  • alprazolam/paracetamol
  • alprazolam/melatonin
  • azithromycin/ambroxol
  • atorvastatin/clopidogrel/aspirin
  • aceclofenac, paracetamol and serratiopeptidase
  • alfacalcidol, vitamin B-complex, minerals and antioxidants
  • alpha- lipoic acid, vitamin b complex and vitamin c
  • alpha-galactosidase and simethicone
  • alpha-galactosidase, amylase, proteases, lipase and lactase
  • amikacin and cefepime
  • aminophylline, ephedrine and phenobarbitone
  • artesunate, sulphadoxine and pyrimethamine
  • finasteride/tamsulosin
  • flavoxate/ofloxacin
  • fenofibrate/metformin
  • lignocaine, hydrocortisone topical and allantoin
  • linoleic acid and sodium lactate
  • troxerutin
  • meclizine/nicotinic acid
  • mecobalamin/ginkgo Biloba
  • spirulina
  • loperamide and furazolidone
  • ketoconazole/cetrimide
  • ketoconazole/zinc pyrithione
  • lercanidipine/atenolol
  • levocetirizine/montelukast/ambroxol
  • levarterenol
  • levocetirizine/phenylpropanolamine 
  • indapamide/amlodipine
  • itopride/methyl polysiloxane
  • mebendazole/levamisole
  • eberconazole/mometasone
  • gliclazide/metformin/pioglitazone
  • fluconazole/tinidazole
  • haemocoagulase
  • halometasone
  • hesperidin
  • imipramine/chlordiazepoxide
  • idebenone / l-arginine / zinc sulphate/selenium/proanthocyanidin
  • mecobalamin and piracetam
  • mesterolone
  • mosapride and pantoprazole
  • atorvastatin, co enzyme q10, vitamin e, zinc, and selenium
  • azithromycin and benzalkonium chloride
  • beta carotene, vitamin c, vitamin e, minerals, lutein, eicosapentaenoic acid, docosahexenoic acid and vit b12
  • alpha-galactosidase
  • aloe vera gel/vitamin e/lactic acid
  • aloe vera gel/jojoba/vitamin e/glycerine
  • famotidine and domperidone
  • faropenem medoxomil
  • nedosiran
  • fluconazole/ornidazole/azithromycin
  • ebastine/montelukast
  • eberconazole
  • dienogest/estradiol valerate
  • ambroxol/salbutamol
  • benzoic acid/salicylic acid/ichthammol/ triamcinolone acetonide
  • desloratadine/ambroxol
  • dexibuprofen/paracetamol
  • atorvastatin/ramipril
  • diastase
  • diastase and simethicone
  • diazepam and propranolol
  • dexrabeprazole / domperidone
  • dexrabeprazole
  • dexketoprofen /paracetamol
  • beta carotene/vitamin C/minerals
  • aloe vera gel/urea
  • aloe vera gel/glycerine
  • alpha-lipoic acid/benfotiamine/chromium/folic acid/mecobalamin / vit b6
  • alprazolam/propranolol
  • alprazolam /sertraline
  • ibuprofen/dextropropoxyphene
  • ambroxol/cetirizine/phenylephrine/ guaiphenesin/menthol
  • dextropropoxyphene/dexchlorpheniramine maleate/bromhexine
  • promegestone
  • batroxobin
  • bencyclane
  • benfluorex
  • acetylpheneturide
  • abarelix
  • abetimus
  • naftidrofuryl
  • nalorphine
  • oxiracetam
  • letosteine
  • lafutidine
  • leuprorelin
  • levodropropizine
  • glutaral
  • losartan/ramipril
  • gallopamil
  • lanatoside c
  • lauromacrogol
  • gestodene
  • aceclofenac/methyl salicylate/menthol/linseed oil/capsaicin
  • aceclofenac/paracetamol/tizanidine
  • alginic acid/magaldrate/simethicone
  • aceclofenac/paracetamol
  • aceclofenac/rabeprazole
  • alginic acid
  • pantoprazole and domperidone
  • urokinase
  • rimiterol
  • olanzapine/fluoxetine
  • normethadone/hydroxyephedrine
  • myrtol
  • moxonidine
  • propylhexedrine
  • sodium hypochlorite solution
  • sodium chloride/sodium citrate
  • Hepatitis B Vaccine (Recombinant [Adjuvanted])
  • Hepatitis B Vaccine (Recombinant)
  • aceclofenac and serratiopeptidase
  • levosulpiride
  • niaprazine
  • tromantadine
  • trimetazidine
  • vinburnine
  • mizoribine
  • molgramostim
  • mosapride
  • eugenol
  • tolperisone
  • etamsylate
  • etynodiol
  • mizolastine
  • metenolone
  • reproterol
  • rebamipide
  • mephenoxalone
  • metandienone
  • furosemide/spironolactone
  • hydroxycarbamide
  • tenonitrozole
  • fenoverine
  • fenquizone
  • tiapride
  • tibolone
  • furazolidone
  • furosemide & amiloride
  • fosfestrol
  • fluclorolone
  • flubendazole
  • tertatolol
  • tetracosactide
  • tetryzoline
  • tolciclate
  • trapidil
  • troxipide
  • temoporfin
  • telbivudine
  • teprenone
  • hexamidine
  • mebhydrolin
  • mepartricin
  • fencamfamin
  • medazepam
  • theodrenaline
  • thiamazole
  • thiocolchicoside
  • psilocybin
  • veralipride
  • pyritinol
  • opipramol
  • oprelvekin
  • betamethasone + gentamicin
  • betamethasone + neomycin
  • betamethasone + salicylic acid
  • oxedrine
  • bopindolol
  • orgotein (investigational)
  • oxaceprol
  • ormeloxifene
  • bevantolol
  • bifemelane
  • clebopride
  • demoxytocin
  • cicletanine
  • cefsulodin
  • chlortalidon
  • sisomicin
  • somatrem
  • carbazochrome
  • caroverine
  • cathine
  • ipriflavone
  • isepamicin
  • silymarin
  • simethicone
  • sermorelin
  • diloxanide
  • dimethindene
  • diosmin/hesperidin
  • calamine
  • canrenone
  • captodiame
  • imidapril
  • cefetamet
  • cefodizime
  • cefoperazone + sulbactam
  • ivermectin + albendazole
  • serrapeptase
  • bromisoval
  • beraprost
  • pridinol
  • proglumide
  • bamipine
  • barnidipine
  • bamifylline
  • benzbromarone
  • betamethasone/fusidic acid
  • para-chlorophenol
  • pantethine
  • nomifensine
  • pemoline
  • parnaparin
  • pentolinium
  • nialamide
  • novobiocin
  • nicergoline
  • octocrylene
  • octisalate
  • oftasceine
  • oxolamine
  • oxyphencyclimine
  • penfluridol
  • pentoxyverine
  • phenoxymethylpenicillin
  • picloxydine
  • pilsicainide hydrochloride
  • piperazine
  • pirarubicin
  • policresulen
  • prifinium bromide
  • prethcamide
  • pristinamycin
  • pirenzepine
  • piribedil
  • pimethixene
  • pargyline
  • phosphatidyl choline
  • phthalylsulfathiazole
  • phytomenadione
  • pranlukast
  • pinazepam
  • oxyphenonium
  • noxytiolin
  • periciazine
  • pethidine
  • phenindamine
  • histidine
  • isoleucine
  • proline
  • lauric acid
  • lymecycline
  • hypromellose
  • abiraterone acetate and niraparib
  • ichthammol
  • levamisole
  • naftazone
  • nefopam
  • oxprenolol
  • oxybuprocaine
  • elranatamab-bcmm
  • lapyrium
  • isoaminile
  • iotrolan
  • mazindol
  • masoprocol
  • lypressin
  • meradimate
  • molsidomine
  • monobenzone
  • mequinol/gluconolactone/ lactobionic acid/ arbutin
  • medifoxamine
  • mebutamate
  • metergoline
  • methantheline
  • methdilazine
  • metocurine
  • micronomicin
  • metaraminol
  • mephenesin
  • menadione
  • medrysone
  • metixene
  • levobetaxolol
  • guaiacol glycerol ether
  • eucalyptol
  • sodium tetradecyl sulfate
  • sugammadex
  • carbetocin
  • certoparin
  • chlorcyclizine/pseudoephedrine
  • cephapirin
  • indecainide
  • iobitridol
  • iomeprol
  • chlorphenesin
  • msud analog
  • msud maxamum
  • iceland moss
  • glutethimide
  • hexachlorophene
  • haloprogin
  • deferoxamine
  • ethchlorvynol
  • dexpanthenol topical
  • etilefrine
  • deslanoside
  • carbocromen
  • diazolidinylurea
  • dibenzepin
  • etofamide
  • guanoxan
  • halazepam
  • guanadrel sulfate
  • dapiprazole
  • soapwort
  • debrisoquine
  • l-tryptophan
  • chlormerodrin
  • chlorquinaldol
  • cetrimonium
  • carbocisteine
  • chlorcyclizine/codeine
  • technetium Tc-99m tetrofosmin
  • technetium Tc-99m disofenin
  • technetium Tc-99m gluceptate
  • technetium Tc-99m labeled red blood cells
  • amylmetacresol/dextromethorphan hydrobromide
  • anileridine phosphate
  • pyrethrins
  • pyrantel pamoate
  • quinagolide
  • spiramycin
  • standard hyperkalemic cardioplegia solution
  • technetium tc-99m mertiatide
  • technetium tc-99m medronate
  • bemotrizinol / bisoctrizole
  • benfotiamine
  • bemotrizinol + titanium dioxide + zinc oxide
  • technetium Tc-99m oxidronate
  • technetium Tc-99m pentetate
  • technetium Tc-99m pyrophosphate
  • benziodarone
  • octinoxate/bisoctrizole
  • bicisate dihydrochloride
  • technetium Tc-99m bicisate
  • norelgestromin/ethinyl estradiol
  • norgestimate/ethinyl estradiol
  • ximelagatran (investigational)
  • xamoterol
  • trioxsalen
  • poly-urea urethane
  • rilmenidine
  • pemirolast
  • oxitriptan
  • beclomethasone, intranasal
  • thimerosal
  • camphor gel
  • camphor
  • mumps virus vaccine, live
  • rubella virus vaccine, live
  • aluminum chloride (dental)
  • alum irrigation
  • framycetin, phenylephrine, and gramicidin
  • ombitasvir, paritaprevir, ritonavir, and dasabuvir
  • olipudase alfa
  • etonogestrel/ethinyl estradiol
  • mycophenolate
  • fluoroestradiol F 18
  • donor organ cardioplegia solution
  • fluciclovine F 18
  • fusidic acid (ophthalmic)
  • fusidic acid and hydrocortisone
  • framycetin, dexamethasone, and gramicidin
  • fludeoxyglucose F-18
  • fluorouracil/salicylic acid
  • indium In-111 oxyquinoline
  • indium In-111 pentetreotide
  • indium In-111 capromab pendetide
  • lusutrombopag
  • mitomycin (ophthalmic)
  • mifepristone and misoprostol
  • minoxidil (systemic)
  • methyl aminolevulinate (topical)
  • methyl folate, methylcobalamin, and acetylcysteine
  • ciclesonide/formoterol/tiotropium
  • nedocromil (Oral Inhalation)
  • batefenterol (Investigational)
  • neostigmine and glycopyrrolate
  • nepafenac ophthalmic
  • netupitant/palonosetron
  • meperidine and promethazine
  • mepivacaine and levonordefrin
  • maltodextrin
  • medical cannabis
  • medium chain triglycerides
  • mometasone/glycopyrrolate (glycopyrronium)/ indacaterol
  • moxifloxacin ophthalmic
  • neomycin/fluocinolone
  • nadroparin
  • iodine I-125 iothalamate
  • amikacin liposome (oral inhalation)
  • bupivacaine liposome
  • natamycin
  • lopinavir and ritonavir
  • lysine
  • macitentan and tadalafil
  • mitomycin pyelocalyceal
  • moclobemide
  • mometasone and indacaterol
  • efinaconazole
  • blue-green algae
  • indocyanine green
  • follitropin beta
  • lumasiran
  • glycerin/lidocaine
  • edrophonium/atropine
  • indigo carmine
  • lutropin alfa
  • instant glucose/intravenous dextrose
  • iobenguane I-123
  • ixekizumab
  • isosulfan blue dye
  • levofloxacin ophthalmic
  • levonorgestrel oral/ferrous bisglycinate/ ethinylestradiol
  • ethinyl estradiol/levonorgestrel transdermal
  • hydroquinone
  • hydroxypropyl methylcellulose
  • icodextrin
  • lipid emulsion (soybean, medium-chain triglyceride, olive, and fish oils; [SMOF])
  • iodinated I 125 albumin
  • iodinated I 131 albumin
  • lipid emulsion (plant oil-based)
  • levonorgestrel intrauterine
  • levonorgestrel/ethinyl estradiol
  • lactic acid and sodium-PCA
  • lactated Ringer solution
  • ketotifen (systemic)
  • lanolin
  • leuprolide and norethindrone
  • levodopa and benserazide
  • gonadorelin acetate
  • hemodialysis solutions
  • nirsevimab
  • gentian violet
  • gallium ga-68 dotatate
  • fusidic acid and betamethasone
  • gallium citrate Ga-67
  • gadopentetate dimeglumine
  • gadofosveset
  • follitropin delta
  • follitropin alfa and lutropin alfa
  • follitropin alfa
  • rocatinlimab
  • grass pollens allergen extract
  • flotufolastat F18
  • fluorescein ophthalmic
  • barium
  • balanced salt solution
  • air polymer type A intrauterine device
  • clodronate
  • bentoquatam
  • clobetasone
  • alfacalcidol
  • citric acid/glucono-delta-lactone/magnesium carbonate
  • benzoin
  • desirudin
  • immune globulin IV (IGIV)
  • dequalinium
  • pseudoephedrine/desloratadine
  • clofedanol
  • cyproterone and ethinyl estradiol
  • dextranomer and hyaluronic acid or derivatives
  • diatrizoate meglumine and diatrizoate sodium
  • glucosamine sulfate, chondroitin sulfate and Msm
  • squill
  • gotu kola
  • blessed thistle
  • bitter melon
  • apraclonidine
  • chlophedianol/dexbrompheniramine/pseudoephedrine
  • wild jujube
  • chitosan
  • cilazapril/hydrochlorothiazide
  • dexbrompheniramine and phenylephrine
  • diethylene triamine penta-acetic acid
  • dexchlorpheniramine and pseudoephedrine
  • lily of the valley
  • diflucortolone
  • corydalis
  • lemon balm
  • MSM
  • calcium polystyrene sulfonate
  • caprylidene
  • peppermint oil
  • efavirenz/lamivudine/tenofovir DF
  • emtricitabine/tenofovir DF /efavirenz
  • dutasteride/tamsulosin
  • milk thistle
  • centaury
  • horseweed
  • lycopus
  • agrimony
  • alfalfa
  • kava
  • cetrorelix
  • cetylpyridinium
  • chlophedianol and dexbrompheniramine
  • betahistine
  • choline C-11
  • boric acid vaginal suppository
  • aluminum acetate
  • aluminum chloride hexahydrate
  • 14-C urea breath test
  • absorbable collagen
  • valoctocogene roxaparvovec-rvox
  • amlodipine and celecoxib
  • aspirin and omeprazole
  • azilsartan and chlorthalidone
  • landiolol (Pending FDA approval)
  • isosorbide dinitrate/hydralazine
  • losartan/hydrochorothiazide
  • udenafil
  • dextromethorphan/quinidine
  • onasemnogene abeparvovec
  • orphenadrine/aspirin/caffeine
  • Trace elements
  • sodium phenylbutyrate/ taurursodiol
  • fish oil triglycerides
  • infant formula
  • glutamine
  • chloroquine phosphate
  • afatinib
  • quinidine gluconate
  • methylergonovine
  • prothrombin complex concentrate, human
  • BCG intravesical live
  • capivasertib
  • cedazuridine
  • carbonyl iron
  • iron dextran complex
  • lovotibeglogene autotemcel (FDA Approval Pending)
  • sodium benzoate/sodium phenylacetate
  • mineral oil otic
  • zolmitriptan transdermal
  • midazolam intranasal
  • fosinopril/hydrochlorothiazide
  • caplacizumab
  • arginine
  • sodium phenylbutyrate
  • meloxicam/rizatriptan
  • manganese
  • acetaminophen/pamabrom/pyridoxine
  • varicella zoster immune globulin, human
  • amitriptyline/perphenazine
  • narsoplimab (Pending FDA Approval)
  • amlodipine/perindopril
  • imiglucerase
  • canagliflozin/metformin
  • tafamidis meglumine
  • somatrogon-ghla
  • glimepiride/rosiglitazone
  • becaplermin
  • lithium
  • loxapine inhaled
  • nicotine transdermal
  • tixagevimab and cilgavimab (Investigational)
  • muromonab CD3
  • ansuvimab
  • coal tar bath products
  • fibrin sealant
  • arimoclomol (FDA Approval Pending)
  • varenicline intranasal
  • aducanumab
  • oxycodone/naloxone
  • ritlecitinib
  • sodium polystyrene sulfonate
  • calcipotriene/betamethasone
  • calcium hydroxylapatite
  • cantharidin topical
  • doxepin cream
  • clocortolone
  • formaldehyde topical
  • sodium sulfide topical
  • collagenase
  • selegiline transdermal
  • foscarbidopa/foslevodopa (FDA approval pending)
  • saxagliptin/metformin
  • linagliptin/metformin
  • linzagolix (FDA approval pending)
  • efgartigimod/hyaluronidase SC
  • Elamipretide
  • rozanolixizumab
  • diazoxide
  • glimepiride/pioglitazone
  • cipaglucosidase alfa
  • dihydroergotamine intranasal
  • delandistrogene moxeparvovec
  • beremagene geperpavec
  • hyaluronic acid and derivatives
  • hyaluronic acid, non-animal stabilized
  • eplontersen (FDA Approval Pending)
  • nitric oxide gas
  • sodium phenylbutyrate and taurursodiol
  • treprostinil SC
  • viltolarsen
  • albuterol/ipratropium
  • budesonide inhaled
  • budesonide rectal
  • palovarotene
  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  • amino acids mixture
  • aminobenzoate potassium
  • elivaldogene autotemcel
  • naproxen and sumatriptan
  • sumatriptan intranasal
  • alglucerase
  • metformin/rosiglitazone
  • ertugliflozin/metformin
  • elosulfase alfa
  • calcium carbonate/magnesium hydroxide
  • starch suppository
  • abicipar pegol (FDA Approval Pending)
  • riboflavin 5′-phosphate ophthalmic
  • povidone ophthalmic
  • glycerin oropharyngeal
  • dimethicone topical
  • menthol topical, dimethicone topical
  • pramoxine topical, menthol topical and dimethicone topical
  • phosphorated carbohydrate
  • brilliant blue G ophthalmic
  • brolucizumab intravitreal
  • purified water, ophthalmic
  • hydroxyethyl cellulose ophthalmic
  • ranibizumab intravitreal implant
  • sodium chloride hypertonic, ophthalmic 
  • cetirizine ophthalmic
  • phentolamine ophthalmic
  • ganciclovir ophthalmic
  • triamcinolone intravitreal
  • ocriplasmin intravitreal
  • atoltivimab/maftivimab/odesivimab
  • pegcetacoplan intravitreal
  • triamcinolone acetonide extended-release injectable suspension
  • tobramycin/loteprednol ophthalmic
  • 2-octyl cyanoacrylate
  • vitamins A & D topical
  • diphenhydramine/allantoin topical
  • pyrethrins/piperonyl butoxide
  • lodoxamide ophthalmic
  • obeticholic acid
  • fluocinolone intravitreal implant
  • sincalide
  • linaclotide
  • nedocromil ophthalmic
  • cysteamine ophthalmic
  • avacincaptad pegol intravitreal
  • azelastine ophthalmic
  • bacitracin ophthalmic
  • propylene glycol ophthalmic
  • rimexolone ophthalmic
  • metoclopramide intranasal
  • mirikizumab
  • netarsudil ophthalmic
  • cenegermin
  • dexamethasone ophthalmic insert
  • prednisolone ophthalmic
  • phenylephrine and cocoa butter rectal
  • phenylephrine and witch hazel topical
  • phenylephrine, pramoxine, glycerin and petrolatum rectal
  • bisacodyl rectal
  • aluminum hydroxide/magnesium carbonate
  • aluminum hydroxide/magnesium hydroxide
  • hyoscyamine spray
  • methenamine/methylene blue/ hyoscyamine/ sodium phosphate monobasic/ phenyl salicylate
  • phenylephrine
  • chlorophyll
  • castor oil
  • cholic acid
  • phenol oropharyngeal
  • articaine/epinephrine
  • antithymocyte globulin equine
  • aluminum hydroxide/magnesium trisilicate
  • methenamine/hyoscyamine
  • hydrocortisone topical/pramoxine topical 
  • sodium fluoride topical
  • mesna
  • C1 esterase inhibitor recombinant
  • menthol and pectin
  • menthol oropharyngeal
  • pectin oropharyngeal
  • gepirone
  • Goldenseal
  • polyethylene glycol and electrolytes
  • polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid
  • brompheniramine/pseudoephedrine/dextromethorphan
  • brompheniramine phenylephrine
  • acetaminophen/doxylamine/phenylephrine
  • doxylamine/acetaminophen/pseudoephedrine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan/phenylephrine
  • eslicarbazepine
  • fluticasone and salmeterol
  • codeine, acetaminophen, butalbital and caffeine
  • codeine, chlorpheniramine and phenylephrine
  • iodine
  • povidone iodine
  • butalbital/aspirin/caffeine/codeine
  • polyethylene glycol 400/propylene glycol ophthalmic 
  • pegvaliase
  • amivantamab
  • iopamidol
  • codeine and pseudoephedrine
  • emtricitabine, rilpivirine, tenofovir DF
  • penicillin G aqueous
  • miconazole topical
  • miconazole vaginal
  • ciprofloxacin inhaled (Pending FDA approval)
  • ceftazidime/avibactam
  • ceftolozane/​tazobactam
  • aztreonam inhalation
  • amphotericin B cholesteryl sulfate
  • miconazole oral
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF
  • isavuconazonium sulfate
  • dapivirine intravaginal (FDA Approval Pending)
  • lamivudine/raltegravir
  • codeine/triprolidine/pseudoephedrine
  • cadexomer iodine
  • brompheniramine/pseudoephedrine
  • codeine/acetaminophen
  • codeine/guaifenesin
  • beclomethasone inhaled
  • epoetin beta/methoxy polyethylene glycol
  • voreloxin(Orphan Drug)
  • rociletinib
  • pitcher plant
  • phosphatidylserine
  • telotristat ethyl
  • copper CU 64 dotatate
  • urea topical
  • exenatide subdermal implant
  • asenapine transdermal
  • ethiodized oil
  • urea oral
  • miglustat
  • acalisib(Investigational)
  • acetophenazine
  • guggul
  • aceneuramic acid
  • mestranol/norethindrone
  • reishi
  • lactitol
  • vonoprazan fumarate
  • motherwort
  • silver nitrate
  • salicylic acid/sulfur shampoo
  • salicylic acid topical
  • ketorolac ophthalmic
  • ketoconazole topical
  • Japanese encephalitis virus vaccine
  • dibucaine topical ointment
  • ketorolac intranasal
  • ketorolac/phenylephrine ophthalmic
  • rotavirus oral vaccine, live
  • guarana
  • hops
  • krill oil
  • salicylic acid/coal tar shampoo
  • sufentanil SL
  • pancrelipase
  • passion flower
  • pepdite one plus
  • nivolumab and relatlimab
  • relatlimab (Pending FDA Approval)
  • benzalkonium chloride/benzocaine
  • ketotifen, drug-eluting contact lens
  • calcitriol topical
  • oxymetazoline topical
  • alclometasone topical
  • capsaicin topical
  • diclofenac/misoprostol
  • diclofenac ophthalmic
  • diclofenac topical
  • pramoxine/calamine topical
  • veverimer
  • tolazoline
  • olopatadine ophthalmic
  • lutetium lu 177-dota-tate
  • lutetium lu 177 vipivotide tetraxetan
  • strontium 89 chloride
  • interferon alfa n3
  • lutetium Lu 177- Diethylenetriamine Pentaacetic acid-omburtamab (FDA Approval Pending)
  • samarium sm 153 lexidronam
  • cytomegalovirus immune globulin (CMV IG)
  • antithymocyte globulin rabbit
  • inolimomab (Pending FDA Approval)
  • olopatadine intranasal
  • olopatadine intranasal/​mometasone, intranasal
  • benzocaine/butamben/tetracaine topical
  • antipyrine/benzocaine/phenylephrine
  • dyclonine/menthol
  • surufatinib
  • fruquintinib
  • dostarlimab
  • hepatitis B immune globulin (HBIG)
  • remestemcel-L
  • benzocaine/menthol oropharyngeal
  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • human rabies immune globulin (HRIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • Methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-hydroxytryptophan (5-htp)
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine, live
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
diphenoxylate/atropine + 

Severity : Monitor Closely
may have an increased CNS depressant effect when combined with CNS depressants

remifentanil

may have an increased CNS depressive effect when combined with opioid agonists

hydrocodone/pseudoephedrine

may have an increased CNS depressive effect when combined with opioid agonists

codeine

may have an increased CNS depressive effect when combined with opioid agonists

morphine

may have an increased CNS depressive effect when combined with opioid agonists

hydroxyzine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

levocabastine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

mepyramine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

acrivastine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

alimemazine

CNS Depressants: they may increase the CNS depressant effect of antihistamines

hydrocodone and homatropine

may have an increased CNS depressant effect when combined with opioid agonists

dezocine

may have an increased CNS depressant effect when combined with opioid agonists

buprenorphine

may have an increased CNS depressant effect when combined with opioid agonists

trimebutine

may have an increased CNS depressant effect when combined with opioid agonists

dextropropoxyphene

may have an increased CNS depressant effect when combined with opioid agonists

hydroxyzine

hydroxyzine may enhance the CNS depressant effect of CNS depressants

lemborexant

lemborexant may enhance the CNS depressant effect of CNS depressants

methotrimeprazine

CNS depressants may enhance the CNS depressant effect of methotrimeprazine

buprenorphine 

may increase the CNS depressant effect

daridorexant 

may enhance the CNS depressant effect

dexmedetomidine 

may enhance the CNS depressant effect

droperidol 

may enhance the CNS depressant effect

zolpidem 

may enhance the CNS depressant effect

chlormethiazole 

may increase the CNS depressant effect

hydroxyzine 

may increase the CNS depressant effect

nalbuphine 

may increase the depressant effect of opioid agonists

paregoric 

may increase the CNS depressant effect of opioid agonists

levorphanol 

may increase the CNS depressant effect

tapentadol 

may increase the CNS depressant of opioid agonists

flunitrazepam 

may have an increased CNS depressant effect when combined with flunitrazepam

lemborexant 

may have an increased CNS depressive effect when combined with CNS depressants

methotrimeprazine 

may have an increased CNS depressive effect when combined with methotrimeprazine

oxycodone 

may have an increased CNS depressive effect when combined with oxycodone

suvorexant 

may have an increased CNS depressive effect when combined with suvorexant

calcium, magnesium, potassium and sodium oxybate 

may have an increased CNS depressant effect when combined with oxybate salt products

ropeginterferon alfa 2b 

may have an increasingly adverse effect when combined with ropeginterferon alfa-2b

remifentanil

may have an increased CNS depressant effect when combined with opioid agonists

hydrocodone/pseudoephedrine

may have an increased CNS depressant effect when combined with opioid agonists

codeine

may have an increased CNS depressant effect when combined with opioid agonists

morphine

may have an increased CNS depressant effect when combined with opioid agonists

methohexital 

may increase the CNS depressant effect of CNS depressants

nalmefene 

nalmefene: they may decrease the therapeutic effect of Opioid Agonists

buprenorphine buccal 

may increase the CNS depressant effect of Buprenorphine

buprenorphine,long-acting injection 

may increase the CNS depressant effect of Buprenorphine

ketazolam 

may increase the risk of CNS depression when combined with 1,2-Benzodiazepine

dexmethylphenidate 

dexmedetomidine: they may increase the CNS depressant effect of CNS Depressants

oxolamine 

oxolamine: they may increase the CNS depressant effect of CNS Depressants

clozapine 

clozapine: they may increase the CNS depressant effect of CNS Depressants

nitrazepam 

nitrazepam: they may increase the CNS depressant effect of CNS Depressants

obinutuzumab 

obinutuzumab: they may increase the CNS depressant effect of CNS Depressants

secretin 

secretin: they may increase the CNS depressant effect of CNS Depressants

cimetropium 

cimetropium: they may increase the CNS depressant effect of CNS Depressants

guanethidine 

guanethidine: they may increase the CNS depressant effect of CNS Depressants

potassium phosphate 

potassium phosphate: they may increase the CNS depressant effect of CNS Depressants

amisulpride 

amisulpride: they may increase the CNS depressant effect of CNS Depressants

tiotropium 

tiotropium: they may increase the CNS depressant effect of CNS Depressants

nitroglycerin 

nitroglycerin: they may increase the CNS depressant effect of CNS Depressants

ramosetron 

ramosetron: they may increase the CNS depressant effect of CNS Depressants

cocaine 

cocaine: they may increase the CNS depressant effect of CNS Depressants

linezolid 

linezolid: they may increase the CNS depressant effect of CNS Depressants

oxychlorosene 

oxychlorosene: they may increase the CNS depressant effect of CNS Depressants

abciximab 

abciximab: it may decrease the excretion rate of abacavir CNS depressant

propoxiphene hydrochloride 

combining CNS depressants with propoxyphene may result in an additive CNS depression

rimonabant 

rimonabant has the potential to intensify the effects of additional central nervous system depressants, including alcohol, benzodiazepines, and opioids, resulting in heightened sedation or respiratory depression

benorilate 

benorilate: it may increase the risk of CNS depression

benoxaprofen 

benoxaprofen: it may increase the risk of CNS depression

alpelisib 

alpelisib: it may increase the risk of CNS depression

alogliptin 

alogliptin: it may increase the risk of CNS depression

albendazole 

albendazole: it may increase the risk of CNS depression

acyclovir 

acyclovir: it may increase the risk of CNS depression

benzydamine 

benzydamine: it may increase the risk of CNS depression

cannabidiol 

cannabidiol: it may increase the risk of CNS depression

capsaicin 

capsaicin: it may increase the risk of CNS depression

captopril 

captopril: it may increase the risk of CNS depression

amobarbital 

amobarbital: it may decreased the serum concentration of CNS depressants

eluxadoline

may have an increased CNS depressant effect when combined with opioid agonists

naldemedine

may have an increased CNS depressant effect when combined with opioid agonists

cimetidine

it increases the effect of diphenoxylate by decreasing the metabolism

glucagon

it increases the effect of atropine when used simultaneously

linezolid

it increases the toxicity of diphenoxylate through an unknown mechanism

macimorelin

when used with atropine, macimorelin shows unspecified drug interaction

phenelzine

it increases the toxicity of diphenoxylate through an unknown mechanism

revefenacin

when used together with atropine, it shows anticholinergic effects

selegiline

it increases the toxicity of diphenoxylate through an unknown mechanism

tranylcypromine

it increases the toxicity of diphenoxylate through an unknown mechanism

azelastine

it increases the effect of CNS depressants

bromperidol

it increases the effect of CNS depressants

kratom

it increases the effect of CNS depressants

olopatadine

it increases the effect of CNS depressants

orphenadrine

CNS depressants increase the effect of orphenadrine

oxomemazine

it increases the effect of CNS depressants

paraldehyde

CNS depressants increase the effect of paraldehyde

bromeperidol

it increases the effect of CNS depressants

bromeperidol 

may increase the CNS depressant effect

thalidomide 

may increase the CNS depressant effect

olopatadine 

may increase the CNS depressant effect

eluxadoline 

may increase the constipation effect of opioid agonist

kratom 

may increase the CNS depressant effect

flunarizine 

CNS depressants increase the effect of flunarizine

orphenadrine 

CNS depressants increase the effect of orphenadrine

oxomemazine 

it increases the effect of CNS depressants

paraldehyde 

CNS depressants increase the CNS depressing effect of paraldehyde

azelastine/fluticasone intranasal 

may increase the CNS depressant effect

flibanserin 

may increase the CNS depressant effect of flibanserin

rasagiline 

may increase the hypertensive effect of Monoamine Oxidase Inhibitors

olopatadine intranasal 

olopatadine (Nasal): they may increase the CNS depressant effect of CNS Depressants

azelaic acid 

azelaic acid: they may increase the CNS depressant effect of CNS Depressants

ipratropium 

ipratropium: they may increase the CNS depressant effect of CNS Depressants

levosalbutamol 

levosalbutamol: they may increase the CNS depressant effect of CNS Depressants

naltrexone 

naltrexone: they may increase the CNS depressant effect of CNS Depressants

furosemide 

furosemide: it may increase the CNS depressant effect of CNS Depressants

aclidinium 

aclidinium: they may increase the CNS depressant effect of CNS Depressants

mequitazine 

mequitazine: they may increase the CNS depressant effect of CNS Depressants

glycopyrrolate 

glycopyrrolate: they may increase the CNS depressant effect of CNS Depressants

chlorthalidone 

chlorthalidone: they may increase the CNS depressant effect of CNS Depressants

revefenacin 

revefenacin: they may increase the CNS depressant effect of CNS Depressants

pitolisant 

pitolisant: they may increase the CNS depressant effect of CNS Depressants

betahistine 

betahistine: they may increase the CNS depressant effect of CNS Depressants

chloral hydrate 

chloral hydrate: they may increase the CNS depressant effect of CNS Depressants

doxofylline 

doxofylline: they may increase the CNS depressant effect of CNS Depressants

brompheniramine

may increase the efficacy of each other when combined

remimazolam

may increase the harmful effects of CNS depressants

primidone

may increase the harmful effects of CNS depressants

phenobarbital

may increase the harmful effects of CNS depressants

amobarbital

may increase the harmful effects of CNS depressants

butalbital

may increase the harmful effects of CNS depressants

alprazolam

diphenoxylate, when used with alprazolam, increases sedation

baclofen

diphenoxylate, when used with baclofen, increases sedation

cinnarizine

diphenoxylate, when used with cinnarizine, increases sedation

droperidol

diphenoxylate, when used with droperidol, increases sedation

hydroxyzine

diphenoxylate, when used with hydroxyzine, increases sedation

lofexidine

diphenoxylate, when used with lofexidine, increases sedation

metaxalone

diphenoxylate, when used with metaxalone, increases sedation

nalbuphine

diphenoxylate, when used with nalbuphine, increases sedation

papaverine

diphenoxylate, when used with papaverine, increases sedation

ziconotide

diphenoxylate, when used with ziconotide, increases sedation

diphenoxylate/atropine

CNS depressants increase the toxicity of CNS depressants

phenobarbital

CNS depressants increase the toxicity of CNS depressants

clozapine

CNS depressants increase the toxicity of CNS depressants

ketamine

CNS depressants increase the toxicity of CNS depressants

propofol

CNS depressants increase the toxicity of CNS depressants

nabilone

may increase the CNS depressant effect of cannabinoid-containing products

cannabidiol

may increase the CNS depressant effect of cannabinoid-containing products

hydrocodone/pseudoephedrine

may increase the CNS depressant effect of opioid agonists

codeine

may increase the CNS depressant effect of opioid agonists

morphine

may increase the CNS depressant effect of opioid agonists

diphenoxylate/atropine

may increase the risk of adverse effect of other CNS depressants

phenobarbital

may increase the risk of adverse effect of other CNS depressants

estazolam

may increase the risk of adverse effect of other CNS depressants

oxazepam

may increase the risk of adverse effect of other CNS depressants

tiagabine

may increase the risk of adverse effect of other CNS depressants

apomorphine

may enhance the adverse/toxic effect of other CNS depressants

flurazepam

may enhance the adverse/toxic effect of other CNS depressants

perphenazine

may enhance the adverse/toxic effect of other CNS depressants

diazepam

may enhance the risk of adverse/toxic effect of other CNS depressants

methadone

may enhance the risk of adverse/toxic effect of other CNS depressants

secobarbital

may enhance the risk of adverse/toxic effect of other CNS depressants

remifentanil

may enhance the CNS depressant effect of Opioid Agonists

hydrocodone/pseudoephedrine

may enhance the CNS depressant effect of Opioid Agonists

codeine

may enhance the CNS depressant effect of Opioid Agonists

morphine

may enhance the CNS depressant effect of Opioid Agonists

clorazepic acid

they increase the toxicity of other CNS depressants

isoflurane

they increase the toxicity of other CNS depressants

promazine

they increase the toxicity of other CNS depressants

famprofazone

may enhance the risk of adverse effect of amphetamines

lisdexamfetamine

may enhance the risk of adverse effect of amphetamines

methamphetamine

may enhance the risk of adverse effect of amphetamines

dextroamphetamine

may enhance the risk of adverse effect of amphetamines

pseudoephedrine

may enhance the risk of adverse effect of amphetamines

eluxadoline

may increase the CNS depressant effect

naldemedine

may increase the CNS depressant effect

droxidopa

could increase the vasopressor action

dextroamphetamine

they decrease the effect of each other by pharmacodynamic antagonism

armodafinil

they decrease the effect of each other by pharmacodynamic antagonism

amphetamine

they decrease the effect of each other by pharmacodynamic antagonism

benzphetamine

they decrease the effect of each other by pharmacodynamic antagonism

caffeine

they decrease the effect of each other by pharmacodynamic antagonism

acamprosate

may have an increased CNS depressant effect when combined with alcohol

lumefantrine

may have an increased CNS depressant effect when combined with alcohol

metamizole

it may enhance the CNS depressant effect

piroxicam

it may enhance the CNS depressant effect

flunarizine

CNS Depressants may enhance the CNS depressant effect of flunarizine

lisuride

lisuride may enhance the CNS depressant effect of CNS Depressants

lofexidine

lofexidine may enhance the CNS depressant effect of CNS depressants

perampanel

perampanel may enhance the CNS depressant effect of CNS Depressants

rotigotine

CNS depressants may enhance the sedative effect of rotigotine

thalidomide

CNS Depressants may enhance the CNS depressant effect of thalidomide

brexanolone

CNS depressants increase the CNS depressing effect of brexanolone

lumefantrine

CNS depressants increase the CNS depressing effect of alcohol

esketamine

it increases the effect of CNS depressants

diphenoxylate/atropine

CNS depressants increase the toxicity of CNS depressants

phenobarbital

CNS depressants increase the toxicity of CNS depressants

clozapine

CNS depressants increase the toxicity of CNS depressants

ketamine

CNS depressants increase the toxicity of CNS depressants

propofol

CNS depressants increase the toxicity of CNS depressants

doxylamine

it increases the effect of CNS depressants

metoclopramide

it increases the effect of CNS depressants

minocycline

it increases the effect of CNS depressants

pramipexole

CNS depressants increase the effect of sedation of pramipexole

ropinirole

CNS depressants increase the effect of sedation of ropinirole

diphenoxylate/atropine

may increase the risk of adverse effect of other CNS depressants

phenobarbital

may increase the risk of adverse effect of other CNS depressants

estazolam

may increase the risk of adverse effect of other CNS depressants

oxazepam

may increase the risk of adverse effect of other CNS depressants

tiagabine

may increase the risk of adverse effect of other CNS depressants

alizapride 

may increase the CNS depressant effect

metoclopramide 

may increase the CNS depressant effect

minocycline 

may increase the CNS depressant effect

amantadine 

may enhance the activity

azelastine 

may increase the CNS depressant effect

difelikefalin 

may increase the CNS depressant effect

lisuride 

may increase the CNS depressant effect

lofexidine 

may increase the CNS depressant effect

magnesium sulfate 

may increase the CNS depressant effect

procarbazine 

may increase the CNS depressant effect

ropinirole 

may increase the sedative effect of CNS depressants

rotigotine 

may increase the sedative effect of CNS depressants

nabilone

may enhance the CNS depressant effect of cannabinoid-containing products

cannabidiol

may enhance the CNS depressant effect of cannabinoid-containing products

apomorphine

may enhance the adverse/toxic effect of other CNS depressants

flurazepam

may enhance the adverse/toxic effect of other CNS depressants

perphenazine

may enhance the adverse/toxic effect of other CNS depressants

bromopride 

it increases the effect of CNS depressants

diazepam

may enhance the risk of adverse/toxic effect of other CNS depressants

methadone

may enhance the risk of adverse/toxic effect of other CNS depressants

secobarbital

may enhance the risk of adverse/toxic effect of other CNS depressants

brimonidine 

may increase the CNS depressant effect

avapritinib 

may increase the toxic effects

brexanolone 

may have an increased CNS depressant effect when combined with brexanolone

may have an increased CNS depressant effect when combined with CNS depressants

doxylamine 

may have an increased CNS depressive effect when combined with CNS depressants

esketamine 

may have an increased CNS depressive effect when combined with CNS depressants

ixabepilone 

may have an increased CNS depressive effect when combined with CNS depressants

magnesium sulfate  

may have an increased CNS depressive effect when combined with CNS depressants

clorazepic acid

they increase the toxicity of other CNS depressants

isoflurane

they increase the toxicity of other CNS depressants

promazine

they increase the toxicity of other CNS depressants

perampanel 

it increases the effect of CNS depressants

rufinamide 

it increases the toxicity of CNS depressants

trimeprazine 

it increases the effect of CNS depressants

fenfluramine 

may have an increased CNS depressant effect when combined with Cyproheptadine

carbinoxamine 

may increase the toxic effect of CNS depressants

carisoprodol 

may increase the toxic effect of CNS depressants

molindone 

may increase the toxic effect of CNS depressants

meprobamate 

may increase the toxic effect of CNS depressants

thiothixene 

may increase the toxic effect of CNS depressants

fexofenadine 

may increase the toxic effect of CNS depressants

promethazine/dextromethorphan 

may increase the toxic effect of other CNS Depressants

sevoflurane 

may increase the adverse effect of CNS Depressants

pramipexole 

pramipexole: they may increase the sedative effect of CNS Depressants

valerian 

valerian: they may increase the CNS depressant effect of CNS Depressants

aripiprazole 

may increase the toxic effect of CNS Depressants

tranylcypromine

may increase the serotonergic effects

isocarboxazid

may increase the serotonergic effects

phenelzine

may increase the serotonergic effects

selegiline

may increase the serotonergic effects

safinamide

may increase the serotonergic effects

tranylcypromine

may increase the serotonergic effects

isocarboxazid

may increase the serotonergic effects

phenelzine

may increase the serotonergic effects

rasagiline

may increase the serotonergic effects

safinamide

may increase the serotonergic effects

acetaminophen/doxylamine/dextromethorphan 

may increase the CNS depressant effect of Doxylamine

metyrosine 

metyrosine: they may increase the sedative effect of CNS Depressants

chloroprocaine 

chloroprocaine: they may increase the CNS depressant effect of CNS Depressants

kava 

kava: they may increase the CNS depressant effect of CNS Depressants

levothyroxine 

levothyroxine: they may increase the CNS depressant effect of CNS Depressants

mianserin 

mianserin: they may increase the CNS depressant effect of CNS Depressants

ozanimod 

ozanimod: they may increase the CNS depressant effect of CNS Depressants

magnesium glucoheptonate

may have an increased CNS depressant effect when combined with CNS depressants

magnesium carbonate

may have an increased CNS depressant effect when combined with CNS depressants

magnesium chloride

may have an increased CNS depressant effect when combined with CNS depressants

magnesium citrate

may have an increased CNS depressant effect when combined with CNS depressants

magnesium gluconate

may have an increased CNS depressant effect when combined with CNS depressants

benzyl alcohol 

benzyl alcohol: they may increase the CNS depressant effect of CNS Depressants

dimethindene 

dimethindene: they may increase the CNS depressant effect of CNS Depressants

piribedil 

piribedil: it may increase the CNS depressant effect of CNS Depressants

potassium citrate 

potassium citrate: they may increase the CNS depressant effect of CNS Depressants

lutropin alfa 

lutropin alfa: they may increase the CNS depressant effect of CNS Depressants

ceritinib 

ceritinib: they may increase the CNS depressant effect of CNS Depressants

dasatinib 

dasatinib: they may increase the CNS depressant effect of CNS Depressants

flecainide 

flecainide: they may increase the CNS depressant effect of CNS Depressants

halofantrine 

halofantrine: they may increase the CNS depressant effect of CNS Depressants

lomitapide 

lomitapide: they may increase the CNS depressant effect of CNS Depressants

methadone 

methadone: they may increase the CNS depressant effect of CNS Depressants

pilsicainide hydrochloride 

pilsiicainide hydrochloride: they may increase the CNS depressant effect of CNS Depressants

glucagon 

glucagon: they may increase the CNS depressant effect of CNS Depressants

hyaluronidase 

hyaluronidase: they may increase the CNS depressant effect of CNS Depressants

mirabegron 

mirabegron: they may increase the CNS depressant effect of CNS Depressants

solriamfetol 

solriamfetol: they may increase the CNS depressant effect of CNS Depressants

tedizolid 

tedizolid: they may increase the CNS depressant effect of CNS Depressants

aminolevulinic acid 

aminolevulinic acid: they may increase the CNS depressant effect of CNS Depressants

sparsentan 

sparsentan: they may increase the CNS depressant effect of CNS Depressants

alfuzosin 

alfuzosin: they may increase the CNS depressant effect of CNS Depressants

arginine 

arginine: they may increase the CNS depressant effect of CNS Depressants

dapoxetine 

dapoxetine: they may increase the CNS depressant effect of CNS Depressants

dexketoprofen 

dexketoprofen: they may increase the CNS depressant effect of CNS Depressants

diacerein 

diacerein: they may increase the CNS depressant effect of CNS Depressants

indoramin 

indoramin: they may increase the CNS depressant effect of CNS Depressants

aliskiren 

aliskiren: they may increase the CNS depressant effect of CNS Depressants

lithium 

lithium: they may increase the CNS depressant effect of CNS Depressants

sacubitril 

sacubitril: they may increase the CNS depressant effect of CNS Depressants

aprotinin 

aprotinin: they may increase the CNS depressant effect of CNS Depressants

methylphenidate 

methylphenidate: they may increase the CNS depressant effect of CNS Depressants

molsidomine 

molsidomine: they may increase the CNS depressant effect of CNS Depressants

naftopidil 

naftopidil: they may increase the CNS depressant effect of CNS Depressants

pholcodine 

pholcodine: they may increase the CNS depressant effect of CNS Depressants

urokinase 

urokinase: they may increase the CNS depressant effect of CNS Depressants

lumefantrine

may increase the CNS depressant effect of CNS depressants

abacavir 

abacavir: it may decrease the excretion rate of abacavir CNS depressant

abatacept 

abatacept: it may decrease the excretion rate of abacavir CNS depressant

acebutolol 

acebutolol: it may decrease the excretion rate of abacavir CNS depressant

aceclofenac 

aceclofenac: it may decrease the excretion rate of abacavir CNS depressant

acemetacin 

acemetacin: it may decrease the excretion rate of abacavir CNS depressant

acenocoumarol 

acenocoumarol: it may decrease the excretion rate of abacavir CNS depressant

acetohexamide 

acetohexamide: it may decrease the excretion rate of abacavir CNS depressant

aldesleukin 

aldesleukin: it may decrease the excretion rate of abacavir CNS depressant

alefacept 

alefacept: it may decrease the excretion rate of abacavir CNS depressant

allopurinol 

allopurinol: it may decrease the excretion rate of abacavir CNS depressant

bacitracin 

bacitracin: it may decrease the excretion rate of abacavir CNS depressant

baricitinib 

baricitinib: it may decrease the excretion rate of abacavir CNS depressant

benazepril 

benazepril: it may decrease the excretion rate of abacavir CNS depressant

benserazide 

benserazide: it may decrease the excretion rate of abacavir CNS depressant

acetazolamide 

acetazolamide: it may increase the risk or severity of CNS depression

balsalazide 

balsalazide: it may increase the risk or severity of CNS depression

mepyramine 

mepyramine: it may increase the risk or severity of CNS depression

acrivastine 

acrivastine: it may increase the risk or severity of CNS depression

adenosine 

adenosine: it may increase the risk or severity of CNS depression

ajmaline 

ajmaline: it may increase the risk or severity of CNS depression

alfentanil 

alfentanil: it may increase the risk or severity of CNS depression

alprazolam 

alprazolam: it may increase the risk or severity of CNS depression

baclofen 

baclofen: it may increase the risk or severity of CNS depression

alvimopan 

alvimopan: it may increase the risk or severity of CNS depression

bufexamac 

bufexamac: it may increase the risk or severity of CNS depression

butabarbital 

butabarbital: it may increase the risk or severity of CNS depression

carbidopa 

carbidopa: it may increase the risk or severity of CNS depression

carboplatin 

carboplatin: it may increase the risk or severity of CNS depression

carmustine 

carmustine: it may increase the risk or severity of CNS depression

carprofen 

carprofen: it may increase the risk or severity of CNS depression

carvedilol 

carvedilol: it may increase the risk or severity of CNS depression

dalfampridine 

dalfampridine: it may increase the risk or severity of CNS depression

cefaclor 

cefaclor: it may increase the risk or severity of CNS depression

bedaquiline 

bedaquiline: it may increase the risk or severity of CNS depression

cariprazine 

cariprazine: it may increase the risk or severity of CNS depression

cetirizine (systemic) 

cetirizine: it may increase the risk or severity of CNS depression

celiprolol 

celiprolol: it may increase the risk or severity of CNS depression

dabrafenib 

dabrafenib: it may increase the risk or severity of CNS depression

dapagliflozin 

dapagliflozin: it may increase the risk or severity of CNS depression

alosetron 

alosetron: it may increase the risk or severity of CNS depression

benzphetamine 

benzphetamine: it may increase the risk or severity of CNS depression

agomelatine 

agomelatine: it may increase the risk or severity of CNS depression

metocurine 

metocurine: it may increase the risk or severity of CNS depression

amoxicillin 

amoxicillin: it may increase the risk or severity of CNS depression

ampicillin 

ampicillin: it may increase the risk or severity of CNS depression

anagrelide 

anagrelide: it may increase the risk or severity of CNS depression

apomorphine 

apomorphine: it may increase the risk or severity of CNS depression

benzylpenicillin 

benzylpenicillin: it may increase the risk or severity of CNS depression

amphetamine 

amphetamine: it may decreased the serum concentration of CNS depressants

anakinra 

anakinra: it may decreased the serum concentration of CNS depressants

antipyrine 

antipyrine: it may decreased the serum concentration of CNS depressants

arbutamine 

arbutamine: it may decreased the serum concentration of CNS depressants

arformoterol 

arformoterol: it may decreased the serum concentration of CNS depressants

binimetinib 

binimetinib: it may increase the metabolism of CNS depressants

bortezomib 

bortezomib: it may increase the metabolism of CNS depressants

brivaracetam 

brivaracetam: it may increase the metabolism of CNS depressants

cenobamate 

cenobamate: it may increase the metabolism of CNS depressants

chlordiazepoxide 

chlordiazepoxide: it may increase the metabolism of CNS depressants

chlorpromazine 

chlorpromazine: it may increase the metabolism of CNS depressants

oxybuprocaine 

oxybuprocaine: it may increase the metabolism of CNS depressants

axitinib 

axitinib: it may increase the metabolism of CNS depressants

pergolide 

pergolide: it may increase the risk of CNS depression

boceprevir 

boceprevir: it may increase the risk of CNS depression

bosentan 

bosentan: it may increase the risk of CNS depression

bretylium 

bretylium: it may increase the risk of CNS depression

brexpiprazole 

brexpiprazole: it may increase the risk of CNS depression

hyoscine butylbromide 

the sedative property of hyoscine may be increased

diphenhydramine 

this preparation contains diphenhydramine and may enhance the impact of alcohol and other central nervous system depressants, including opioid analgesics, anticonvulsants, antihistamines, antidepressants, antiemetics, anxiolytic sedatives, antipsychotics, and hypnotics

clomipramine

it increases the toxicity of atropine through an unknown mechanism

lofepramine

it increases the toxicity of atropine through an unknown mechanism

protriptyline

it increases the toxicity of atropine through an unknown mechanism

trimipramine

it increases the toxicity of atropine through an unknown mechanism

alizapride

it increases the effect of CNS depressants

primidone

CNS depressants increases the concentration of serum barbiturates in the serum

phenobarbital

CNS depressants increases the concentration of serum barbiturates in the serum

amobarbital

CNS depressants increases the concentration of serum barbiturates in the serum

butalbital

CNS depressants increases the concentration of serum barbiturates in the serum

butabarbital

CNS depressants increases the concentration of serum barbiturates in the serum

bromopride

it increases the effect of CNS depressants

bupivacaine

CNS depressants increases the toxicity of bupivacaine

difelikefalin

it increases the effect of CNS depressants

magnesium sulfate

it increases the effect of CNS depressants

procarbazine

it increases the effect of CNS depressants

blonaserin

CNS depressants increase the effect of blonanserin

daridorexant

it increases the effect of CNS depressants

droperidol

it increases the effect of CNS depressants

oxycodone

CNS depressants increase the effect of oxycodone

zolp

CNS depressants increase the effect of zolpidem

zolpidem

CNS depressants increase the effect of zolpidem

suvorexant

CNS depressants increase the effect of suvorexant

zuranolone 

it increases the effect of CNS depressants

Actions and Spectrum: 

diphenoxylate/atropine is a combination medication used to treat diarrhea. It works by slowing down the movement of the intestines, which reduces the frequency and urgency of bowel movements and helps to relieve diarrhea symptoms. The medication contains two active ingredients: diphenoxylate and atropine. 

diphenoxylate is an opioid agonist that acts on the mu-opioid receptors in the gastrointestinal tract. It works by slowing down the motility of the intestines, reducing the amount of fluid and electrolytes lost through the bowel movements, and improving the consistency of stools. diphenoxylate is structurally like the narcotic pain medication meperidine (Demerol) but has a much lower potential for abuse. 

atropine is added to the formulation to discourage misuse of diphenoxylate, as it can cause unpleasant side effects such as dry mouth, blurred vision, and urinary retention. Atropine also has some antidiarrheal effects on its own, as it reduces intestinal motility and secretions and can help to relieve cramps and spasms. 

The combination of diphenoxylate and atropine has a broad spectrum of activity against different types of diarrhea, including acute and chronic diarrhea caused by infectious, inflammatory, or functional disorders. However, it is not recommended for use in patients with bacterial infections or other specific causes of diarrhea, as it may interfere with the elimination of the infectious agent and delay the resolution of the infection. 

1-10% 

Abdominal discomfort 

Anticholinergic effects 

Blurred vision 

Dryness of skin/mouth 

Nausea 

Vomiting 

Sedation 

Frequency not defined 

Pancreatitis 

Toxic megacolon 

Diphenoxylate/atropine is contraindicated in children under 6 years of age due to the risk of respiratory depression, coma, and death, especially when overdosed. Extreme caution must be used when administering this medication to pediatric patients, and it should never be used in children under the age of 2. Use only the lowest effective dose for the shortest possible duration to minimize the risk of serious adverse effects. 

Contraindication/Caution: 

Allergy or hypersensitivity to diphenoxylate, atropine, or any of the ingredients in the formulation. 

  • Severe liver disease or hepatic encephalopathy, as the medication may worsen these conditions. 
  • Infectious diarrhea caused by bacteria, viruses, or parasites, as the medication may slow down the elimination of the infectious agent and delay the resolution of the infection. 
  • Glaucoma or other eye conditions that can be worsened by the anticholinergic effects of atropine. 
  • Respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD), as the medication may cause respiratory depression or worsen these conditions. 
  • Pregnancy or breastfeeding, as the safety and efficacy of the medication have not been established in these populations. 

Caution should also be exercised when using diphenoxylate/atropine in patients with certain medical conditions, such as inflammatory bowel disease, kidney disease, or heart disease, as well as in patients taking other medications that may interact with diphenoxylate/atropine. The medication may cause drowsiness, dizziness, or impaired coordination, so patients should avoid driving or operating heavy machinery until they know how the medication affects them. 

Pregnancy consideration: diphenoxylate/atropine should be used in pregnancy only if the assumed benefits outweigh potential risks 

Breastfeeding warnings: Some of the active metabolites of the diphenoxylate are secreted in breastmilk but are unknown for atropine 

Hence consult your physician for the same 

Pregnancy category: 

  • Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. 
  • Category B: There is no affirmation of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women. 
  • Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a product in humans; Pregnant women must take care of the potential risks. 
  • Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms. However, despite potential dangers may be used only in emergency cases for potential benefits. 
  • Category X: Drugs listed in this category outweigh risks over benefits. The drug is not for pregnant women. 
  • Category N: No data is available for the drug under this category. 

Pharmacology: 

diphenoxylate/atropine is a combination medication used for the treatment of diarrhea. diphenoxylate is an opioid medication that works by slowing down the movement of the intestines and reducing the frequency and volume of bowel movements. Atropine is added to the medication to discourage abuse of diphenoxylate, which can be addictive if taken in large amounts. 

Pharmacodynamics: 

diphenoxylate is a synthetic opioid agonist that binds to the mu-opioid receptors in the gastrointestinal tract, which slows down the propulsive contractions of the smooth muscle and reduces the secretions in the intestinal tract. This results in reduced peristalsis and increased transit time, which leads to decreased frequency and volume of bowel movements. 

atropine is an antimuscarinic agent that works by blocking the action of acetylcholine at muscarinic receptors in the gastrointestinal tract. atropine inhibits the secretions in the intestinal tract and reduces smooth muscle contractions, which results in a further decrease in bowel movement frequency and volume. 

Pharmacokinetics: 

diphenoxylate is absorbed slowly and incompletely from the gastrointestinal tract. The drug is metabolized in the liver, primarily by glucuronidation, and the metabolites are excreted in the urine. 

atropine is rapidly absorbed from the gastrointestinal tract and is widely distributed throughout the body. The drug is metabolized in the liver and excreted primarily in the urine. 

Administration: 

diphenoxylate/atropine is available as a tablet and is typically taken orally. The recommended dose for adults is 2 tablets (2.5 mg diphenoxylate/0.025 mg atropine per tablet) four times a day or as directed by a healthcare provider. The medication should be taken with a full glass of water. 

It is important to follow the dosing instructions provided by the healthcare provider and not exceed the recommended dose. Diphenoxylate has the potential for abuse and addiction, and taking more than the recommended dose or taking it for longer than prescribed can lead to dependence. 

Patients should not take diphenoxylate/atropine for more than 48 hours without consulting a healthcare provider. If symptoms persist or worsen after 48 hours of treatment, a healthcare provider should be consulted to rule out underlying conditions. Patients should also avoid alcohol while taking diphenoxylate/atropine, as alcohol can increase the sedative effects of the medication. 

In addition to taking diphenoxylate/atropine as directed, patients should also maintain good hydration by drinking plenty of fluids to replace those lost due to diarrhea. Electrolyte replacement solutions may also be recommended in severe cases of diarrhea.

Patient information leaflet 

Generic Name: diphenoxylate/atropine 

Pronounced: dahy-fen-ok-suh-leyt -atruh-peen 

Why do we use diphenoxylate/atropine? 

diphenoxylate/atropine is used to treat acute or chronic diarrhea in adults. It is a combination medication that contains diphenoxylate, an opioid medication that slows down the movement of the intestines and reduces the frequency and volume of bowel movements, and atropine, which is added to the medication to discourage its abuse. 

Diarrhea can result from a variety of causes, including infections, medications, and digestive disorders. The goal of treatment is to reduce the frequency and volume of bowel movements and to alleviate associated symptoms such as cramping, abdominal pain, and dehydration. 

diphenoxylate/atropine can help to slow down the movement of the intestines and reduce the volume and frequency of bowel movements, thereby helping to alleviate the symptoms of diarrhea. atropine is added to the medication to discourage its abuse, as diphenoxylate can be addictive if taken in large amounts. 

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