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November 18, 2025
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Brand Name :
Coumadin,Jantoven 
Synonyms :
APO-Warfarin,TARO-Warfarin
Class :
Anti-coagulant, Vitamin K antagonist 
Brand Name :
Coumadin,Jantoven 
Synonyms :
APO-Warfarin,TARO-Warfarin
Class :
Anti-coagulant, Vitamin K antagonist 
Dosage Forms & Strengths Â
Powder for injection-5mg per vial Â
Tablet form:1,2,2.5,3,4,5,6,7.5,10 mg Â
Initial dose:
2 - 5
mg
oral/IV
every 48 hours
or 10mg oral for 2 days.
Check INR and adjust the dose.
Maintenance-2-10mg/day
Dose Adjustments
Dosing adjustment:
Hepatic impairment: defective synthesis of clotting factors and low metabolism
Kidney impairment: No data available.
Dosage forms and strengths  Â
Powder for injection-5mg per vial Â
Tablet form:1,2,2.5,3,4,5,6,7.5,10 mg Â
Refer adult dosing Â
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
when both drugs are combined, there may be an increase in the anti-coagulant action
it enhances the effects of warfarin by anti-coagulation
may increase the metabolism of vitamin K antagonists
may increase the metabolism of vitamin K antagonists
may increase the metabolism of vitamin K antagonists
may increase the metabolism of vitamin K antagonists
may increase the metabolism of vitamin K antagonists
may increase the anti-coagulant effect of androgens
may increase the anti-coagulant effect of salicylates
may enhance the anticoagulant effect of fibric acid derivatives
may increase the anti-coaugulant effect of salicylates
may increase the anti-coagulant effect of nonsteroidal anti-inflammatory agents
may increase the therapeutic efficacy of warfarin when combined
may increase the CNS depressant effect of CNS depressants
they may diminish the serum concentration when combined with vitamin k antagonists
may enhance the serum concentration when combined with Vitamin K Antagonists
estrogens esterified/methyltestosterone            Â
may increase the anticoagulant effect of Androgens
may increase the anticoagulant effect of Salicylates
may enhance the serum concentration of Antacids
aluminum hydroxide/magnesium carbonateÂ
may enhance the serum concentration of aluminum hydroxide
It may enhance the serum concentration when combined with miconazole (topical)
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
the excretion rate of warfarin may be decreased by oxybenzone
may have an increased anticoagulant effect when combined with vitamin k antagonists
lansoprazole, amoxicillin, and clarithromycin
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may enhance the effect of each other when combined
plantain will reduce the efficacy of warfarin when co-administered
methyltestosterone increases the anticoagulatory effect of warfarin
it decreases the rate of elimination of pidotimod
Interaction decreases the therapeutic effects of warfarin.
pentamycin increases the therapeutic efficacy of warfarin when used in combination
bismuth subsalicylate increases the anticoagulatory effect of warfarin
oxymetholone by anticoagulation increases the effect of warfarin
danazol increases the anticoagulatory effect of warfarin
fluoxymesterone increases the anticoagulatory effect of warfarinÂ
methyltestosterone increases the anticoagulatory effect of warfarin
oxandrolone increases the anticoagulatory effect of warfarin
oxandrolone increases the anticoagulatory effect of warfarin
methyltestosterone increases the anticoagulatory effect of warfarin
allopurinol enhances the effects of warfarin by anti-coagulation
betrixaban enhances the anti-coagulant effects of warfarin
may enhance the toxicity of the other through anti coagulation
may diminish the serum concentration
may increase the risk or severity of gastrointestinal bleeding when combined
allopurinol increases the effect of anticoagulation of vitamin K antagonists
may increase the anticoagulant effect of each other when combined
methyltestosterone increases the anticoagulatory effect of warfarin
metronidazole/tetracycline/bismuth subsalicylateÂ
by the mechanism of anticoagulation, by activity of warfarin may be increased by bismuth subsalicylate
penicillins may iincrease the anticoagulant effect of Vitamin K Antagonists
penicillins may iincrease the anticoagulant effect of Vitamin K Antagonists
penicillins may iincrease the anticoagulant effect of Vitamin K Antagonists
penicillins may iincrease the anticoagulant effect of Vitamin K Antagonists
penicillins may iincrease the anticoagulant effect of Vitamin K Antagonists
quinolones may enhance the anticoagulant effect of Vitamin K antagonists
quinolones may enhance the anticoagulant effect of Vitamin K antagonists
Selective Serotonin Reuptake Inhibitors may enhance the anticoagulant effect of Vitamin K
Selective Serotonin Reuptake Inhibitors may enhance the anticoagulant effect of Vitamin K
Selective Serotonin Reuptake Inhibitors may enhance the anticoagulant effect of Vitamin K
Selective Serotonin Reuptake Inhibitors may enhance the anticoagulant effect of Vitamin K
Selective Serotonin Reuptake Inhibitors may enhance the anticoagulant effect of Vitamin K
may increase the anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may increase the anticoagulant effect of vitamin K antagonist
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
choline magnesium trisalicylate
It may increase the anticoagulant effect when combined with Salicylates (Topical)
It may enhance the serum concentration when combined with CYP2C9 Inhibitors
It may enhance the serum concentration when combined with CYP2C9 Inhibitors
thyroid products increase the effect of anticoagulation of vitamin K antagonists
thyroid products increase the effect of anticoagulation of vitamin K antagonists
thyroid products increase the effect of anticoagulation of vitamin K antagonists
thyroid products increase the effect of anticoagulation of vitamin K antagonists
The miconazole (oral) has the potential to elevate the levels of warfarin in the bloodstream
It may enhance the effects when combined with triamcinolone by unspecified mechanisms interaction
it may diminish the excretion rate when combined with antibiotics, resulting in an enhanced serum level
Vitamin K antagonists: they may increase the antiplatelet effect of antiplatelet agents
Vitamin K antagonists: they may increase the antiplatelet effect of antiplatelet agents
Vitamin K antagonists: they may increase the antiplatelet effect of antiplatelet agents
Vitamin K antagonists: they may increase the antiplatelet effect of antiplatelet agents
Vitamin K antagonists: they may increase the antiplatelet effect of antiplatelet agents
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
when ciprofibrate is given along with warfarin, there is an increased risk of bleeding
warfarin: they may enhance the serum concentration of CYP3A4 inducers
warfarin: they may enhance the serum concentration of CYP3A4 inducers
warfarin: they may enhance the serum concentration of CYP3A4 inducers
warfarin: they may enhance the serum concentration of CYP3A4 inducers
warfarin: they may enhance the serum concentration of CYP3A4 inducers
warfarin excretion rate may be slowed by flupirtine, raising the possibility of higher serum levels
when fentiazac is used with warfarin, the risk or severity of bleeding and hemorrhage is enhanced
when used with warfarin, the therapeutic efficacy of andexanet alfa may be reduced
gadopentetic acid may decrease the excretion rate of warfarin, potentially resulting in a higher serum level
ioxilan may decrease the excretion rate of warfarin, potentially resulting in a higher serum level
the therapeutic efficacy of warfarin may be decreased when used in combination with phylloquinone
mycophenolic acid has the potential to decrease the excretion rate of warfarin, leading to a potential increase in serum levels
n-acetyl tyrosine may decrease the excretion rate of warfarin, potentially leading to higher serum levels
sulbactam may decrease the excretion rate of warfarin, potentially leading to a raised serum level
when coupled with fosnetupitant, the serum concentration of warfarin can be raised
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
nafcillin will decrease the effect of action of warfarin by affecting enzyme CYP3A4 metabolism.
piperacillin increases the effectiveness of warfarin by synergism
When bacampicillin combines with warfarin, there may be increased risk of bleeding in liver and hepatic impairment and mostly in elderly patients.
When penicillin G benzathine combines with warfarin, the increased risk of bleeding is seen in renal or liver impairment and elderly patients.
when both drugs are combined, there may be a decreased level of serum concentration of warfarin   
may increase the serum concentration of warfarin
decreases effects of warfarin
the effect of warfarin is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
gemcitabine, by an unspecific mechanism of interaction, increases the effect of warfarin
the level or effect of warfarin is increased by fluorouracil, by impacting CYP2C9/10 hepatic enzyme metabolism
when both drugs are combined, there may be an increased effect of warfarin by unspecified interaction mechanism  
cefprozil increases the anticoagulant activity of warfarin by an unknown mechanism
cefaclor increases the anticoagulant activity of warfarin by an unknown mechanism
when both drugs are combined, there may be an increased risk of adverse effects  
when both drugs are combined, there may be an increased risk or severity of adverse effects  
cefepime increases the anticoagulant activity of warfarin by an unknown mechanism
When both drugs are combined, there may be an increased risk of adverse effects
cefuroxime increases the anticoagulant activity of warfarin by an unknown mechanism
demeclocycline enhances the therapeutic effects of warfarin
doxycycline enhances the therapeutic effects of warfarin
gefitinib, with the help of an unspecified interaction mechanism, increases the effect of warfarin
idelalisib increases the effect or level of warfarin by altering the intestinal/hepatic CYP3A4 metabolism
sorafenib increases the effect of anticoagulation in warfarin
capreomycin may enhance the anticoagulant effects of warfarin
Coadministration of Zidovudine with warfarin can increase the risk of bleeding or unusual bleeding
Coadministration of Tenofovir alafenamide with warfarin can increase the risk of bleeding or unusual bleeding
lansoprazole amoxicillin and clarithromycin
when amoxicillin combines with warfarin it decreases the effects of the action of drug by increasing bleeding and results in renal and liver impairment
amoxicillin and clavulanate potassium
when amoxicillin combines with warfarin it decreases the effects of the action of drug by increasing bleeding and results in renal and liver impairment
omeprazole amoxicillin and clarithromycin
when amoxicillin combines with warfarin it decreases the effects of the action of the drug by increasing bleeding and results in renal and liver impairment
when amoxicillin combines with warfarin it decreases the effects of the action of the drug by increasing bleeding and results in renal and liver impairment
Coadministration of tipranavir with warfarin can increase the risk of bleeding or unusual bleeding
may increase the metabolism of Vitamin K Antagonists
may increase the metabolism of Vitamin K Antagonists
may increase the metabolism of Vitamin K Antagonists
may increase the metabolism of Vitamin K Antagonists
may increase the metabolism of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may increase the serum concentration of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
may enhance the anticoagulant effect of Vitamin K Antagonists
choline magnesium trisalicylate
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may diminish the anticoagulant effect of Vitamin K Antagonists
May may increase the anti-coagulant action when combined.
May increase the anti-coagulant action when combined.
may increase the serum concentration when both drugs are combined
May increase the anti-coagulant action when combined.
May increase the anti-coagulant action when combined
May increase the anti-coagulant action when combined
May increase the serum concentration when both drugs are combined
May increase the anti-coagulant action when combined
This may increase the anti-coagulant action when combined
May increase the anti-coagulant action when combined
May increase the anti-coagulant action when combined
This may increase the serum concentration when both drugs are combined
May increase the anti-coagulant action when combined
May increase the anti-coagulant action when combined
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
cephalosporins increase the effect of anticoagulation of vitamin K antagonists
vitamin K1 (phytonadione)Â may reduce the anticoagulant effect of vitamin K antagonists
cephalosporins may enhance the anticoagulant effect of vitamin K antagonistsÂ
cephalosporins may enhance the anticoagulant effect of vitamin K antagonistsÂ
cephalosporins may enhance the anticoagulant effect of vitamin K antagonistsÂ
metformin reduces the effect of anticoagulation of vitamin K antagonists
may increase the anticoagulant effect
may increase the anti-coagulant action of anti-coagulants
may increase the anticoagulant effect
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may increase the effect of vitamin K antagonists
may decrease the anticoagulant effect of direct-acting viral agents
may decrease the anticoagulant effect of direct-acting antiviral agents
may increase the anticoagulant effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
relugolix/​estradiol/​norethindrone
may increase the anticoagulant effect
relugolix/estradiol/norethindrone
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect of vitamin K antagonists
may increase the levels of serum concentration of vitamin K antagonists
may increase the levels of serum concentration of vitamin K antagonists
may increase the levels of serum concentration of vitamin K antagonists
may increase the levels of serum concentration of vitamin K antagonists
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
May decrease the serum concentration
May decrease the serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the anticoagulant effect
amoxicillin and clavulanate potassium
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
may enhance the anticoagulant effect
bismuth subcitrate, metronidazole and tetracycline
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
ay enhance the anticoagulant effect
may have an increased anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect of HMG-CoA Reductase Inhibitors
drospirenone/ethinyl estradiol/levomefolateÂ
may enhance the serum concentration of Hormonal Contraceptives
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may decrease the anticoagulant effect of Vitamin K Antagonists
5-Aminosalicylic Acid Derivatives: they may increase the anticoagulant effect of Vitamin K Antagonists
5-Aminosalicylic Acid Derivatives: they may increase the anticoagulant effect of Vitamin K Antagonists
may decrease the anticoagulant effect of Direct Acting Antiviral Agents
may enhance the serum concentration of Hormonal Contraceptives
etonogestrel/ethinyl estradiolÂ
may increase the serum concentration of Hormonal Contraceptives
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
oxaceprol decreases the effect of vitamin K antagonists
It may enhance the risk of adverse effects when combined with Peptide Hormones
rolapitant: they may enhance the serum concentration of warfarin
when combined with bacitracin, the serum level of warfarin will increase, leading to decreased output of warfarin from the body
enhanced efficacy of warfarin with cinoxacin is seen
sulfisoxazole will decrease the metabolism of warfarin
may increase the anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect when combined with vitamin k antagonists
The severity of hemorrhage and bleeding can be raised if bumadizone is taken with warfarin
may increase the anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect when combined with vitamin k antagonists
the rate of excretion of warfarin may be decreased with aurothioglucose
viscum abietis increases warfarin's anticoagulant action
may have an increased anticoagulant effect when combined with vitamin k antagonists
may have an increased anticoagulant effect when combined with vitamin k antagonists
meningococcal A C Y and W-135 diphtheria conjugate vaccine
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
may increase the anticoagulant effect of Cephalosporins
the risk of bleeding can be increased
proquazone and warfarin together may increase the likelihood of bleeding and hemorrhage
the rate of metabolism of zotepine may be reduced with warfarin
miconazole nitrate/hydrocortisoneÂ
the activity of oral anticoagulants may be increased
relugolix/​estradiol/​norethindrone
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
relugolix/estradiol/norethindrone
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
fibric acid derivatives increase the effect of anticoagulation of vitamin K antagonists
androgens increase the effect of anticoagulation of vitamin K antagonists like warfarin
Actions and Spectrum:Â
Action:Â
Warfarin is an oral anticoagulant drug that is used to reduce the formation of blood clots by blocking the production of active components of the coagulation system. It acts as an anticoagulant; it inhibits the actions of vitamin K which is involved in oxidizing certain clotting factors. Warfarin acts by blocking the enzyme vitamin K epoxide reductase (VKOR) that is critical to reducing vitamin K to its readily usable form of the vitamin. This inhibition in turn, inhibit production of vitamin K dependent clotting factors such as II(prothrombin), VII, IX, X but also protein C and S which are anticoagulant factors.
Spectrum:
Warfarin is employed in the prevention and management of DVT, a condition characterized by the development of a blood clot in a deep vein, where it commonly occurs in a person’s legs.
It also acts as a prevents and treats pulmonary embolism, this is a situation where a blood clot reaches the lungs.Â
Frequency defined  Â
1-10% Â
Cholesterol embolism syndrome Â
Calciphylaxis Â
Hemorrhage Â
<1% Â
Dermatitis Â
Vasculitis Â
Hepatitis Â
Alopecia Â
Black Box Warning:Â
It may cause major or fatal bleeding.  Â
Contraindication/Caution Â
PregnancyÂ
Active BleedingÂ
Severe HypertensionÂ
Liver DiseaseÂ
Renal ImpairmentÂ
HypersensitivityÂ
Avoid neonates and infants less than 4 months old due to a higher risk of bleeding. Â
Pregnancy/Lactation   Â
Pregnancy consideration: Category X (US FDA) Â
Lactation: The presence of the drug in human breast milk is unknown. Â
Pregnancy category: Â
Pharmacology:Â
Warfarin is an anticoagulant agent.Â
Pharmacodynamics:Â
Warfarin acts by blocking the synthesis of the vitamin k dependent clotting factors. These include Factor II (prothrombin), Factor VII, Factor IX, Factor X, Protein C and Protein S, the mechanism by means of which warfarin causes its action is by blocking vitamin K epoxide reductase (VKOR) enzymes which are responsible for recycling back active vitamin K from its epoxide form. This inhibition results in a decrease in the manufacture of the active clotting factors and this therefore leads to prevention of formation of blood clots.Â
Pharmacokinetics:Â
AbsorptionÂ
The onset of action of drug is 36 to 48 hours.Â
The peak plasma time is 1.5 to 3 days.Â
DistributionÂ
It is highly protein-bound (~99%), primarily to albumin.Â
The volume of distribution is 0.14 L/kg.Â
MetabolismÂ
Warfarin is metabolized in the liver by cytochrome P450 enzymes, particularly CYP2C9, CYP1A2, and CYP3A4. There are two enantiomers of warfarin, S-warfarin and R-warfarin, with S-warfarin being more potent.Â
Excretion and EliminationÂ
The elimination half-life of the drug is 20 to 60 hour.Â
Administration   Â
The warfarin is administered through oral and intravenous route.Â
Patient information leaflet Â
Generic Name: Warfarin (Rx) Â
Pronounced: [WAR-far-in] Â
Why do we use warfarin? Â
Warfarin belongs to the class of anti-coagulant. It is used to reduce the formation of blood clots in veins and arteries, thereby reducing the risk of heart attack or stroke. Â
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